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Spatial profiling of giant cell arteritis tissues reveals immune heterogeneity and potential predictors of glucocorticoid response.

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Title: Spatial profiling of giant cell arteritis tissues reveals immune heterogeneity and potential predictors of glucocorticoid response.
Authors: Ansalone C; School of Infection and Immunity, University of Glasgow, Glasgow, UK. Electronic address: Cecilia.ansalone@glasgow.ac.uk., McAllister S; School of Infection and Immunity, University of Glasgow, Glasgow, UK., Pickerill ES; Eli Lilly and Company, Indianapolis, IN, USA., Zhang L; Eli Lilly and Company, Indianapolis, IN, USA., Gemperline DC; Eli Lilly and Company, Indianapolis, IN, USA., Peacock A; School of Infection and Immunity, University of Glasgow, Glasgow, UK., Gupta I; School of Infection and Immunity, University of Glasgow, Glasgow, UK., Mcgovern D; NHS Greater Glasgow and Clyde, Glasgow, UK., Kellior V; School of Infection and Immunity, University of Glasgow, Glasgow, UK., Qian E; School of Infection and Immunity, University of Glasgow, Glasgow, UK., Tulunay Virlan A; School of Infection and Immunity, University of Glasgow, Glasgow, UK., Vieri ML; School of Infection and Immunity, University of Glasgow, Glasgow, UK., Leslie H; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Doncheva Y; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Kennedy Dietrich C; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Wright S; NHS Greater Glasgow and Clyde, Glasgow, UK., Cauchi P; NHS Greater Glasgow and Clyde, Glasgow, UK., Beckman T; NHS Greater Glasgow and Clyde, Glasgow, UK., Hutton L; NHS Greater Glasgow and Clyde, Glasgow, UK., Cole J; School of Infection and Immunity, University of Glasgow, Glasgow, UK., Jamieson NB; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Wulur IH; Eli Lilly and Company, Indianapolis, IN, USA., Nirula A; Lilly Biotechnology Center, San Diego, CA, USA., McInnes IB; School of Infection and Immunity, University of Glasgow, Glasgow, UK., Benschop RJ; Eli Lilly and Company, Indianapolis, IN, USA., Goodyear CS; School of Infection and Immunity, University of Glasgow, Glasgow, UK., Basu N; School of Infection and Immunity, University of Glasgow, Glasgow, UK. Electronic address: neil.basu@glasgow.ac.uk.
Source: Annals of the rheumatic diseases [Ann Rheum Dis] 2026 Mar; Vol. 85 (3), pp. 534-546. Date of Electronic Publication: 2025 Oct 18.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ansalone+C%22">Ansalone C</searchLink>; School of Infection and Immunity, University of Glasgow, Glasgow, UK. Electronic address: Cecilia.ansalone@glasgow.ac.uk.<br /><searchLink fieldCode="AU" term="%22McAllister+S%22">McAllister S</searchLink>; School of Infection and Immunity, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Pickerill+ES%22">Pickerill ES</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Gemperline+DC%22">Gemperline DC</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Peacock+A%22">Peacock A</searchLink>; School of Infection and Immunity, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Gupta+I%22">Gupta I</searchLink>; School of Infection and Immunity, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Mcgovern+D%22">Mcgovern D</searchLink>; NHS Greater Glasgow and Clyde, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Kellior+V%22">Kellior V</searchLink>; School of Infection and Immunity, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Qian+E%22">Qian E</searchLink>; School of Infection and Immunity, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Tulunay+Virlan+A%22">Tulunay Virlan A</searchLink>; School of Infection and Immunity, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Vieri+ML%22">Vieri ML</searchLink>; School of Infection and Immunity, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Leslie+H%22">Leslie H</searchLink>; School of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Doncheva+Y%22">Doncheva Y</searchLink>; School of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Kennedy+Dietrich+C%22">Kennedy Dietrich C</searchLink>; School of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Wright+S%22">Wright S</searchLink>; NHS Greater Glasgow and Clyde, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Cauchi+P%22">Cauchi P</searchLink>; NHS Greater Glasgow and Clyde, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Beckman+T%22">Beckman T</searchLink>; NHS Greater Glasgow and Clyde, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Hutton+L%22">Hutton L</searchLink>; NHS Greater Glasgow and Clyde, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Cole+J%22">Cole J</searchLink>; School of Infection and Immunity, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Jamieson+NB%22">Jamieson NB</searchLink>; School of Cancer Sciences, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Wulur+IH%22">Wulur IH</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Nirula+A%22">Nirula A</searchLink>; Lilly Biotechnology Center, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22McInnes+IB%22">McInnes IB</searchLink>; School of Infection and Immunity, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Benschop+RJ%22">Benschop RJ</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Goodyear+CS%22">Goodyear CS</searchLink>; School of Infection and Immunity, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Basu+N%22">Basu N</searchLink>; School of Infection and Immunity, University of Glasgow, Glasgow, UK. Electronic address: neil.basu@glasgow.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%220372355%22">Annals of the rheumatic diseases</searchLink> [Ann Rheum Dis] 2026 Mar; Vol. 85 (3), pp. 534-546. <i>Date of Electronic Publication: </i>2025 Oct 18.
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