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Palbociclib with adjuvant endocrine therapy in early breast cancer: 5-year follow-up analysis of the global multicenter, open-label, randomized phase III PALLAS trial (ABCSG-42/AFT-05/PrE0109/BIG-14-13).

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Title: Palbociclib with adjuvant endocrine therapy in early breast cancer: 5-year follow-up analysis of the global multicenter, open-label, randomized phase III PALLAS trial (ABCSG-42/AFT-05/PrE0109/BIG-14-13).
Authors: Mayer EL; Breast Oncology Center, Dana-Farber Cancer Institute, Boston, USA. Electronic address: Erica_Mayer@dfci.harvard.edu., Hlauschek D; ABCSG, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria., Gnant M; ABCSG, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria; Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., O'Brien PJ; Alliance Statistics and Data Center, Mayo Clinic, Rochester, USA., Bellet-Ezquerra M; Vall d'Hebron Institute of Oncology, Barcelona, Spain., Goetz MP; Department of Oncology, Mayo Clinic, Rochester, USA., Ruiz-Borrego M; Oncology Department, Hospital Universitario Virgen del Rocio, Sevilla, Spain., Chan A; Breast Cancer Research Centre, Perth, Australia., Clifton K; Department of Medicine, Division of Oncology, Washington University, Saint Louis, USA., Egle D; ABCSG, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria; Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Austria., Lake D; Breast Medicine Service, Memorial Sloan Kettering Cancer Center, New York, USA., Cabrera P; Department of Oncology, Instituto Nacional De Cancerologia, Mexico D.F, Mexico., Mamounas T; Breast Program, Orlando Health Cancer Institute, Orlando, USA., Pristauz-Telsnigg G; Clinical Department of Gynecology, University Clinic for Obstetrics and Gynecology, Graz, Austria., Dayao Z; NCI-designated Comprehensive Cancer Center, University of New Mexico Hospital, Albuquerque, USA., Gil Gil M; Medical Oncology Department, Institut Català d'Oncologia de L'Hospitalet de Llob, Barcelona, Spain., Cameron D; Edinburgh Cancer Research Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland., Traina T; Breast Medicine Service, Memorial Sloan Kettering Cancer Center, New York, USA., Morris PG; Cancer Trials Ireland, Dublin, Ireland., Sabanathan D; Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia., Rinnerthaler G; ABCSG, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria; Division of Clinical Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Meisel J; Winship Cancer Institute, Emory University, Atlanta, USA., Prat A; Clínic Barcelona Comprehensive Cancer Center, Hospital Clinic, IDIBAPS and University of Barcelona, Barcelona, Spain., Wolff AC; Medical Oncology, Johns Hopkins University, Baltimore, USA., Tseng LM; Taipei-Veterans General Hospital, National Yang Ming Chiao Tung University, Taipei, Taiwan., Isaacs C; Department of Medicine, Georgetown University, Washington, USA., Singer CF; ABCSG, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria; Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Gynecology and Obstetrics, Medical University of Vienna, Vienna, Austria., Rubovszky G; Department of Thoracic and Abdominal Tumors and Clinical Pharmacology, National Institute of Oncology, Budapest, Hungary., Foukakis T; Department of Oncology/Pathology, Karolinska Institute, Stockholm, Sweden., Jassem J; Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland., Winer EP; Yale Cancer Center, Yale University, New Haven, USA., Vetter M; Cancer Center Baselland, Cantonal Hospital Baselland, Liestal, Switzerland., Federmann J; ABCSG, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria., Metzger O; Breast Oncology Center, Dana-Farber Cancer Institute, Boston, USA., Schurmans C; Breast International Group (BIG), Brussels, Belgium., Gauthier E; Pfizer, Inc., San Francisco, USA., Lu DR; Pfizer, Inc., San Diego, USA., Fesl C; ABCSG, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria., Dueck A; Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Scottsdale, USA., DeMichele A; Department of Medicine, University of Pennsylvania, Philadelphia, USA.
Source: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2026 Feb; Vol. 37 (2), pp. 271-277. Date of Electronic Publication: 2025 Oct 17.
Publication Type: Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9007735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-8041 (Electronic) Linking ISSN: 09237534 NLM ISO Abbreviation: Ann Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Palbociclib with adjuvant endocrine therapy in early breast cancer: 5-year follow-up analysis of the global multicenter, open-label, randomized phase III PALLAS trial (ABCSG-42/AFT-05/PrE0109/BIG-14-13).
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  Data: <searchLink fieldCode="AU" term="%22Mayer+EL%22">Mayer EL</searchLink>; Breast Oncology Center, Dana-Farber Cancer Institute, Boston, USA. Electronic address: Erica_Mayer@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Hlauschek+D%22">Hlauschek D</searchLink>; ABCSG, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Gnant+M%22">Gnant M</searchLink>; ABCSG, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria; Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22O'Brien+PJ%22">O'Brien PJ</searchLink>; Alliance Statistics and Data Center, Mayo Clinic, Rochester, USA.<br /><searchLink fieldCode="AU" term="%22Bellet-Ezquerra+M%22">Bellet-Ezquerra M</searchLink>; Vall d'Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Goetz+MP%22">Goetz MP</searchLink>; Department of Oncology, Mayo Clinic, Rochester, USA.<br /><searchLink fieldCode="AU" term="%22Ruiz-Borrego+M%22">Ruiz-Borrego M</searchLink>; Oncology Department, Hospital Universitario Virgen del Rocio, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Chan+A%22">Chan A</searchLink>; Breast Cancer Research Centre, Perth, Australia.<br /><searchLink fieldCode="AU" term="%22Clifton+K%22">Clifton K</searchLink>; Department of Medicine, Division of Oncology, Washington University, Saint Louis, USA.<br /><searchLink fieldCode="AU" term="%22Egle+D%22">Egle D</searchLink>; ABCSG, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria; Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Lake+D%22">Lake D</searchLink>; Breast Medicine Service, Memorial Sloan Kettering Cancer Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Cabrera+P%22">Cabrera P</searchLink>; Department of Oncology, Instituto Nacional De Cancerologia, Mexico D.F, Mexico.<br /><searchLink fieldCode="AU" term="%22Mamounas+T%22">Mamounas T</searchLink>; Breast Program, Orlando Health Cancer Institute, Orlando, USA.<br /><searchLink fieldCode="AU" term="%22Pristauz-Telsnigg+G%22">Pristauz-Telsnigg G</searchLink>; Clinical Department of Gynecology, University Clinic for Obstetrics and Gynecology, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Dayao+Z%22">Dayao Z</searchLink>; NCI-designated Comprehensive Cancer Center, University of New Mexico Hospital, Albuquerque, USA.<br /><searchLink fieldCode="AU" term="%22Gil+Gil+M%22">Gil Gil M</searchLink>; Medical Oncology Department, Institut Català d'Oncologia de L'Hospitalet de Llob, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Cameron+D%22">Cameron D</searchLink>; Edinburgh Cancer Research Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland.<br /><searchLink fieldCode="AU" term="%22Traina+T%22">Traina T</searchLink>; Breast Medicine Service, Memorial Sloan Kettering Cancer Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Morris+PG%22">Morris PG</searchLink>; Cancer Trials Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Sabanathan+D%22">Sabanathan D</searchLink>; Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Rinnerthaler+G%22">Rinnerthaler G</searchLink>; ABCSG, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria; Division of Clinical Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Meisel+J%22">Meisel J</searchLink>; Winship Cancer Institute, Emory University, Atlanta, USA.<br /><searchLink fieldCode="AU" term="%22Prat+A%22">Prat A</searchLink>; Clínic Barcelona Comprehensive Cancer Center, Hospital Clinic, IDIBAPS and University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Wolff+AC%22">Wolff AC</searchLink>; Medical Oncology, Johns Hopkins University, Baltimore, USA.<br /><searchLink fieldCode="AU" term="%22Tseng+LM%22">Tseng LM</searchLink>; Taipei-Veterans General Hospital, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Isaacs+C%22">Isaacs C</searchLink>; Department of Medicine, Georgetown University, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Singer+CF%22">Singer CF</searchLink>; ABCSG, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria; Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Gynecology and Obstetrics, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Rubovszky+G%22">Rubovszky G</searchLink>; Department of Thoracic and Abdominal Tumors and Clinical Pharmacology, National Institute of Oncology, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Foukakis+T%22">Foukakis T</searchLink>; Department of Oncology/Pathology, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Jassem+J%22">Jassem J</searchLink>; Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland.<br /><searchLink fieldCode="AU" term="%22Winer+EP%22">Winer EP</searchLink>; Yale Cancer Center, Yale University, New Haven, USA.<br /><searchLink fieldCode="AU" term="%22Vetter+M%22">Vetter M</searchLink>; Cancer Center Baselland, Cantonal Hospital Baselland, Liestal, Switzerland.<br /><searchLink fieldCode="AU" term="%22Federmann+J%22">Federmann J</searchLink>; ABCSG, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Metzger+O%22">Metzger O</searchLink>; Breast Oncology Center, Dana-Farber Cancer Institute, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Schurmans+C%22">Schurmans C</searchLink>; Breast International Group (BIG), Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Gauthier+E%22">Gauthier E</searchLink>; Pfizer, Inc., San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Lu+DR%22">Lu DR</searchLink>; Pfizer, Inc., San Diego, USA.<br /><searchLink fieldCode="AU" term="%22Fesl+C%22">Fesl C</searchLink>; ABCSG, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Dueck+A%22">Dueck A</searchLink>; Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Scottsdale, USA.<br /><searchLink fieldCode="AU" term="%22DeMichele+A%22">DeMichele A</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, USA.
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  Data: <searchLink fieldCode="JN" term="%229007735%22">Annals of oncology : official journal of the European Society for Medical Oncology</searchLink> [Ann Oncol] 2026 Feb; Vol. 37 (2), pp. 271-277. <i>Date of Electronic Publication: </i>2025 Oct 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9007735 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1569-8041 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209237534%22">09237534 </searchLink><i>NLM ISO Abbreviation: </i>Ann Oncol <i>Subsets: </i>MEDLINE
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