Phosphorylation of UDP-glucose dehydrogenase increases glycosaminoglycan biosynthesis and promotes tumor cell motility, spheroid growth, and therapeutic resistance.

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Title: Phosphorylation of UDP-glucose dehydrogenase increases glycosaminoglycan biosynthesis and promotes tumor cell motility, spheroid growth, and therapeutic resistance.
Authors: Utz AR; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Ma L; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Hilovsky D; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Zimmer BM; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Allego E; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Fluharty J; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Narasimhan P; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Enders JR; Molecular Education, Technology and Research Innovation Center, North Carolina State University, USA., Grady G; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Milici M; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Liu P; Department of Biochemistry and Biophysics, University of North Carolina - Chapel Hill, USA., Liu X; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Barycki JJ; Department of Molecular and Structural Biochemistry, North Carolina State University, USA., Simpson MA; Department of Molecular and Structural Biochemistry, North Carolina State University, USA. Electronic address: msimpso3@ncsu.edu.
Source: Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2025 Dec; Vol. 142, pp. 33-45. Date of Electronic Publication: 2025 Oct 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9432592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-1802 (Electronic) Linking ISSN: 0945053X NLM ISO Abbreviation: Matrix Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phosphorylation of UDP-glucose dehydrogenase increases glycosaminoglycan biosynthesis and promotes tumor cell motility, spheroid growth, and therapeutic resistance.
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  Data: <searchLink fieldCode="AU" term="%22Utz+AR%22">Utz AR</searchLink>; Department of Molecular and Structural Biochemistry, North Carolina State University, USA.<br /><searchLink fieldCode="AU" term="%22Ma+L%22">Ma L</searchLink>; Department of Molecular and Structural Biochemistry, North Carolina State University, USA.<br /><searchLink fieldCode="AU" term="%22Hilovsky+D%22">Hilovsky D</searchLink>; Department of Molecular and Structural Biochemistry, North Carolina State University, USA.<br /><searchLink fieldCode="AU" term="%22Zimmer+BM%22">Zimmer BM</searchLink>; Department of Molecular and Structural Biochemistry, North Carolina State University, USA.<br /><searchLink fieldCode="AU" term="%22Allego+E%22">Allego E</searchLink>; Department of Molecular and Structural Biochemistry, North Carolina State University, USA.<br /><searchLink fieldCode="AU" term="%22Fluharty+J%22">Fluharty J</searchLink>; Department of Molecular and Structural Biochemistry, North Carolina State University, USA.<br /><searchLink fieldCode="AU" term="%22Narasimhan+P%22">Narasimhan P</searchLink>; Department of Molecular and Structural Biochemistry, North Carolina State University, USA.<br /><searchLink fieldCode="AU" term="%22Enders+JR%22">Enders JR</searchLink>; Molecular Education, Technology and Research Innovation Center, North Carolina State University, USA.<br /><searchLink fieldCode="AU" term="%22Grady+G%22">Grady G</searchLink>; Department of Molecular and Structural Biochemistry, North Carolina State University, USA.<br /><searchLink fieldCode="AU" term="%22Milici+M%22">Milici M</searchLink>; Department of Molecular and Structural Biochemistry, North Carolina State University, USA.<br /><searchLink fieldCode="AU" term="%22Liu+P%22">Liu P</searchLink>; Department of Biochemistry and Biophysics, University of North Carolina - Chapel Hill, USA.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Molecular and Structural Biochemistry, North Carolina State University, USA.<br /><searchLink fieldCode="AU" term="%22Barycki+JJ%22">Barycki JJ</searchLink>; Department of Molecular and Structural Biochemistry, North Carolina State University, USA.<br /><searchLink fieldCode="AU" term="%22Simpson+MA%22">Simpson MA</searchLink>; Department of Molecular and Structural Biochemistry, North Carolina State University, USA. Electronic address: msimpso3@ncsu.edu.
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  Data: <searchLink fieldCode="JN" term="%229432592%22">Matrix biology : journal of the International Society for Matrix Biology</searchLink> [Matrix Biol] 2025 Dec; Vol. 142, pp. 33-45. <i>Date of Electronic Publication: </i>2025 Oct 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9432592 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1569-1802 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220945053X%22">0945053X </searchLink><i>NLM ISO Abbreviation: </i>Matrix Biol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.matbio.2025.10.004
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      – Code: eng
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              Text: 2025 Dec
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