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Divergent accumulation patterns of SNVs and INDELs reveal negative selection in noncancerous cells.

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Title: Divergent accumulation patterns of SNVs and INDELs reveal negative selection in noncancerous cells.
Authors: Zhang L; Masonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Lee M; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Hao X; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Ma X; Masonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA., Xia C; Masonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA., Zhao Y; Masonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA., Ehlert J; Department of Physics, Network Science Institute, Northeastern University, Boston, MA 02115, USA., Chi Z; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Jin B; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Cutler R; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Maslov AY; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Barabási AL; Department of Physics, Network Science Institute, Northeastern University, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Network and Data Science, Central European University, 1051 Budapest, Hungary., Hoeijmakers JHJ; Department of Molecular Genetics, Erasmus University Medical Center, 3015 GD Rotterdam, the Netherlands.; University of Cologne, Faculty of Medicine, Cluster of Excellence for Aging Research, Institute for Genome Stability in Ageing and Disease, 50931 Cologne, Germany.; Princess Maxima Center for Pediatric Oncology, Oncode Institute, 3584 CS Utrecht, the Netherlands., Edelmann W; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Vijg J; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Dong X; Masonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Source: Innovation (Cambridge (Mass.)) [Innovation (Camb)] 2025 Jun 25; Vol. 6 (10), pp. 101008. Date of Electronic Publication: 2025 Jun 25 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101771342 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-6758 (Electronic) Linking ISSN: 26666758 NLM ISO Abbreviation: Innovation (Camb) Subsets: PubMed not MEDLINE
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  Data: Divergent accumulation patterns of SNVs and INDELs reveal negative selection in noncancerous cells.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Masonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Lee+M%22">Lee M</searchLink>; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Hao+X%22">Hao X</searchLink>; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Ma+X%22">Ma X</searchLink>; Masonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Xia+C%22">Xia C</searchLink>; Masonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Masonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Ehlert+J%22">Ehlert J</searchLink>; Department of Physics, Network Science Institute, Northeastern University, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Chi+Z%22">Chi Z</searchLink>; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Jin+B%22">Jin B</searchLink>; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Cutler+R%22">Cutler R</searchLink>; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Maslov+AY%22">Maslov AY</searchLink>; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Barabási+AL%22">Barabási AL</searchLink>; Department of Physics, Network Science Institute, Northeastern University, Boston, MA 02115, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Network and Data Science, Central European University, 1051 Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Hoeijmakers+JHJ%22">Hoeijmakers JHJ</searchLink>; Department of Molecular Genetics, Erasmus University Medical Center, 3015 GD Rotterdam, the Netherlands.; University of Cologne, Faculty of Medicine, Cluster of Excellence for Aging Research, Institute for Genome Stability in Ageing and Disease, 50931 Cologne, Germany.; Princess Maxima Center for Pediatric Oncology, Oncode Institute, 3584 CS Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Edelmann+W%22">Edelmann W</searchLink>; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Vijg+J%22">Vijg J</searchLink>; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.<br /><searchLink fieldCode="AU" term="%22Dong+X%22">Dong X</searchLink>; Masonic Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.
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              Text: 2025 Jun 25
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