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Comparative Efficacy of Advanced Therapies for Management of Moderate-to-Severe Crohn's Disease: 2025 AGA Evidence Synthesis.

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Title: Comparative Efficacy of Advanced Therapies for Management of Moderate-to-Severe Crohn's Disease: 2025 AGA Evidence Synthesis.
Authors: Singh S; Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona. Electronic address: singh.siddharth@mayo.edu., Murad MH; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota., Yuan Y; Division of Gastroenterology, Western University, London, Ontario, Canada., Ananthakrishnan AN; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts., Click B; Crohn's and Colitis Center, Division of Gastroenterology and Hepatology, University of Colorado, Anschutz Medical Campus, Denver, Colorado., Syal G; Vatche & Tamar Manoukian Division of Digestive Diseases, School of Medicine, University of California, Los Angeles, Los Angeles, California., Haydek JP; Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Agrawal M; The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York New York; Center for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark., Kappelman MD; Division of Pediatric Gastroenterology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Lewis JD; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Scott FI; Crohn's and Colitis Center, Division of Gastroenterology and Hepatology, University of Colorado, Anschutz Medical Campus, Denver, Colorado.
Source: Gastroenterology [Gastroenterology] 2025 Dec; Vol. 169 (7), pp. 1516-1536. Date of Electronic Publication: 2025 Oct 20.
Publication Type: Journal Article; Systematic Review; Comparative Study; Network Meta-Analysis; Research Support, U.S. Gov't, P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE
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  Data: Comparative Efficacy of Advanced Therapies for Management of Moderate-to-Severe Crohn's Disease: 2025 AGA Evidence Synthesis.
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  Data: <searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona. Electronic address: singh.siddharth@mayo.edu.<br /><searchLink fieldCode="AU" term="%22Murad+MH%22">Murad MH</searchLink>; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Yuan+Y%22">Yuan Y</searchLink>; Division of Gastroenterology, Western University, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ananthakrishnan+AN%22">Ananthakrishnan AN</searchLink>; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Click+B%22">Click B</searchLink>; Crohn's and Colitis Center, Division of Gastroenterology and Hepatology, University of Colorado, Anschutz Medical Campus, Denver, Colorado.<br /><searchLink fieldCode="AU" term="%22Syal+G%22">Syal G</searchLink>; Vatche & Tamar Manoukian Division of Digestive Diseases, School of Medicine, University of California, Los Angeles, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Haydek+JP%22">Haydek JP</searchLink>; Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Agrawal+M%22">Agrawal M</searchLink>; The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York New York; Center for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kappelman+MD%22">Kappelman MD</searchLink>; Division of Pediatric Gastroenterology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Lewis+JD%22">Lewis JD</searchLink>; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Scott+FI%22">Scott FI</searchLink>; Crohn's and Colitis Center, Division of Gastroenterology and Hepatology, University of Colorado, Anschutz Medical Campus, Denver, Colorado.
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  Data: <searchLink fieldCode="JN" term="%220374630%22">Gastroenterology</searchLink> [Gastroenterology] 2025 Dec; Vol. 169 (7), pp. 1516-1536. <i>Date of Electronic Publication: </i>2025 Oct 20.
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