Ticagrelor as a dual RAS modulator and mitochondrial stabilizer: A multifaceted neurotherapeutic strategy in Huntington's disease.

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Title: Ticagrelor as a dual RAS modulator and mitochondrial stabilizer: A multifaceted neurotherapeutic strategy in Huntington's disease.
Authors: Mohamed OE; Postgraduate Program in Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt; Pharmacology and Toxicology Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, 12611, Egypt., Sayed RH; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt; Clinical Pharmacy Department, School of Pharmacy, Newgiza University, Giza, 12577, Egypt., Abdallah DM; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt. Electronic address: dalaal.abdallah@pharma.cu.edu.eg., Abou El-Ezz D; Pharmacology and Toxicology Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, 12611, Egypt., El-Brairy A; Pharmacology Department Modern Sciences and Arts (MSA), Giza, 12611, Egypt; Department of Medical Pharmacology, Faculty of Medicine, Cairo University, Cairo, 11562, Egypt., El-Abhar HS; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.
Source: Neuropharmacology [Neuropharmacology] 2026 Feb 01; Vol. 283, pp. 110726. Date of Electronic Publication: 2025 Oct 20.
Publication Type: Journal Article
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-7064
DOI:10.1016/j.neuropharm.2025.110726