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Mutant p53 regulates cancer cell invasion in complex three-dimensional environments through mevalonate pathway-dependent Rho/ROCK signaling.

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Title: Mutant p53 regulates cancer cell invasion in complex three-dimensional environments through mevalonate pathway-dependent Rho/ROCK signaling.
Authors: Guzman A; Department of Biological Sciences, Columbia University, New York, NY 10027., Kawase T; Astellas Pharma Inc., Tsukuba-shi, Ibaraki 305-8585, Japan., Devanny AJ; Department of Chemistry, Columbia University, New York, NY 10027., Efe G; Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032., Navaridas R; Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032., Yu K; Department of Physics, Columbia University, New York, NY 10027., Regunath K; Department of Biological Sciences, Columbia University, New York, NY 10027., Mercer IG; Department of Chemistry, Columbia University, New York, NY 10027., Avard RC; Department of Chemistry, Columbia University, New York, NY 10027., Muniz de Queiroz R; Department of Biological Sciences, Columbia University, New York, NY 10027., Rustgi AK; Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032., Kaufman LJ; Department of Chemistry, Columbia University, New York, NY 10027., Prives C; Department of Biological Sciences, Columbia University, New York, NY 10027.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Oct 28; Vol. 122 (43), pp. e2424904122. Date of Electronic Publication: 2025 Oct 21.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Guzman+A%22">Guzman A</searchLink>; Department of Biological Sciences, Columbia University, New York, NY 10027.<br /><searchLink fieldCode="AU" term="%22Kawase+T%22">Kawase T</searchLink>; Astellas Pharma Inc., Tsukuba-shi, Ibaraki 305-8585, Japan.<br /><searchLink fieldCode="AU" term="%22Devanny+AJ%22">Devanny AJ</searchLink>; Department of Chemistry, Columbia University, New York, NY 10027.<br /><searchLink fieldCode="AU" term="%22Efe+G%22">Efe G</searchLink>; Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032.<br /><searchLink fieldCode="AU" term="%22Navaridas+R%22">Navaridas R</searchLink>; Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032.<br /><searchLink fieldCode="AU" term="%22Yu+K%22">Yu K</searchLink>; Department of Physics, Columbia University, New York, NY 10027.<br /><searchLink fieldCode="AU" term="%22Regunath+K%22">Regunath K</searchLink>; Department of Biological Sciences, Columbia University, New York, NY 10027.<br /><searchLink fieldCode="AU" term="%22Mercer+IG%22">Mercer IG</searchLink>; Department of Chemistry, Columbia University, New York, NY 10027.<br /><searchLink fieldCode="AU" term="%22Avard+RC%22">Avard RC</searchLink>; Department of Chemistry, Columbia University, New York, NY 10027.<br /><searchLink fieldCode="AU" term="%22Muniz+de+Queiroz+R%22">Muniz de Queiroz R</searchLink>; Department of Biological Sciences, Columbia University, New York, NY 10027.<br /><searchLink fieldCode="AU" term="%22Rustgi+AK%22">Rustgi AK</searchLink>; Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032.<br /><searchLink fieldCode="AU" term="%22Kaufman+LJ%22">Kaufman LJ</searchLink>; Department of Chemistry, Columbia University, New York, NY 10027.<br /><searchLink fieldCode="AU" term="%22Prives+C%22">Prives C</searchLink>; Department of Biological Sciences, Columbia University, New York, NY 10027.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Oct 28; Vol. 122 (43), pp. e2424904122. <i>Date of Electronic Publication: </i>2025 Oct 21.
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