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The fourth-generation EGFR tyrosine kinase inhibitor BLU-945 resensitizes ABCG2-overexpressing multidrug-resistant non-small cell lung cancer cells to cytotoxic anticancer drugs.

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Title: The fourth-generation EGFR tyrosine kinase inhibitor BLU-945 resensitizes ABCG2-overexpressing multidrug-resistant non-small cell lung cancer cells to cytotoxic anticancer drugs.
Authors: Li YC; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan., Lin BH; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan., Murakami M; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Wu YS; Department of Chemistry, Tunghai University, Taichung 40704, Taiwan., Hung TH; Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taipei 10507, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Department of Obstetrics and Gynecology, Keelung Chang Gung Memorial Hospital, Keelung 20401, Taiwan. Electronic address: thh20@adm.cgmh.org.tw., Ambudkar SV; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: ambudkar@mail.nih.gov., Wu CP; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taipei 10507, Taiwan; Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. Electronic address: wuchung@mail.cgu.edu.tw.
Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2025 Dec 01; Vol. 215, pp. 107337. Date of Electronic Publication: 2025 Oct 19.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE
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  Data: The fourth-generation EGFR tyrosine kinase inhibitor BLU-945 resensitizes ABCG2-overexpressing multidrug-resistant non-small cell lung cancer cells to cytotoxic anticancer drugs.
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  Data: <searchLink fieldCode="AU" term="%22Li+YC%22">Li YC</searchLink>; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+BH%22">Lin BH</searchLink>; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Murakami+M%22">Murakami M</searchLink>; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Wu+YS%22">Wu YS</searchLink>; Department of Chemistry, Tunghai University, Taichung 40704, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+TH%22">Hung TH</searchLink>; Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taipei 10507, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Department of Obstetrics and Gynecology, Keelung Chang Gung Memorial Hospital, Keelung 20401, Taiwan. Electronic address: thh20@adm.cgmh.org.tw.<br /><searchLink fieldCode="AU" term="%22Ambudkar+SV%22">Ambudkar SV</searchLink>; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: ambudkar@mail.nih.gov.<br /><searchLink fieldCode="AU" term="%22Wu+CP%22">Wu CP</searchLink>; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Department of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taipei 10507, Taiwan; Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan; Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan. Electronic address: wuchung@mail.cgu.edu.tw.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+B%2EV%22">Elsevier Science B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9317982 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0720 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209280987%22">09280987 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Pharm Sci <i>Subsets: </i>MEDLINE
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              Text: 2025 Dec 01
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