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Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation.

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Title: Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation.
Authors: Li Q; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France., de Oliveira Formiga R; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France., Puchois V; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France., Creusot L; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France., Ahmad AH; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France., Amouyal S; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France., Campos-Ribeiro MA; Institut Pasteur, Mitochondrial Biology Unit, CNRS UMR 3691, Université Paris Cité, Paris, France., Zhao Y; Institut Pasteur, Mitochondrial Biology Unit, CNRS UMR 3691, Université Paris Cité, Paris, France., Harris DMM; Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.; Institute for Human Nutrition and Food Science, Division Nutriinformatics, Kiel University, Kiel, Germany., Lasserre F; Toxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP-Purpan, UPS, Université de Toulouse, Toulouse, France., Ellero-Simatos S; Toxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP-Purpan, UPS, Université de Toulouse, Toulouse, France., Guillou H; Toxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP-Purpan, UPS, Université de Toulouse, Toulouse, France., Huang Z; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France., Brot L; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France., Hu Y; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France., Chollet L; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.; Université Paris-Saclay, INRAe, AgroParisTech, Micalis institute, Jouy-en-Josas, France., Danne C; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France., Scandola C; Institut Pasteur, Université Paris Cité, Ultrastructural Bioimaging Unit, Paris, France., Ledent T; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France., Chevreux G; Université Paris Cité, CNRS, Institut Jacques Monod, Paris, France., Argüello RJ; Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France., De Carvalho Bittencourt M; Université de Lorraine, CNRS, IMoPA, Nancy, France.; Université de Lorraine, CHRU Nancy, Immunology Department, Nancy, France., Bettinger J; Université de Lorraine, CNRS, IMoPA, Nancy, France., D'Aveni-Piney M; Université de Lorraine, CNRS, IMoPA, Nancy, France.; Université de Lorraine, CHRU Nancy, Hematology Department, Nancy, France., Moulin D; Université de Lorraine, CNRS, IMoPA, Nancy, France., Schreiber S; Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.; Department of Internal Medicine I, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany., Aden K; Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.; Department of Internal Medicine I, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany., Rolhion N; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France., Michel ML; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.; Université Paris-Saclay, INRAe, AgroParisTech, Micalis institute, Jouy-en-Josas, France., Wai T; Institut Pasteur, Mitochondrial Biology Unit, CNRS UMR 3691, Université Paris Cité, Paris, France., Sokol H; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France. harry.sokol@gmail.com.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France. harry.sokol@gmail.com.; Université Paris-Saclay, INRAe, AgroParisTech, Micalis institute, Jouy-en-Josas, France. harry.sokol@gmail.com.; Gastroenterology department, Saint Antoine Hospital, APHP, Paris, France. harry.sokol@gmail.com.
Source: Nature metabolism [Nat Metab] 2025 Dec; Vol. 7 (12), pp. 2510-2530. Date of Electronic Publication: 2025 Oct 21.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4<superscript>+</superscript> T cells to confer protection against intestinal inflammation.
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  Data: <searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.<br /><searchLink fieldCode="AU" term="%22de+Oliveira+Formiga+R%22">de Oliveira Formiga R</searchLink>; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.<br /><searchLink fieldCode="AU" term="%22Puchois+V%22">Puchois V</searchLink>; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.<br /><searchLink fieldCode="AU" term="%22Creusot+L%22">Creusot L</searchLink>; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ahmad+AH%22">Ahmad AH</searchLink>; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.<br /><searchLink fieldCode="AU" term="%22Amouyal+S%22">Amouyal S</searchLink>; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.<br /><searchLink fieldCode="AU" term="%22Campos-Ribeiro+MA%22">Campos-Ribeiro MA</searchLink>; Institut Pasteur, Mitochondrial Biology Unit, CNRS UMR 3691, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Institut Pasteur, Mitochondrial Biology Unit, CNRS UMR 3691, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Harris+DMM%22">Harris DMM</searchLink>; Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.; Institute for Human Nutrition and Food Science, Division Nutriinformatics, Kiel University, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Lasserre+F%22">Lasserre F</searchLink>; 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Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.<br /><searchLink fieldCode="AU" term="%22Chollet+L%22">Chollet L</searchLink>; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.; Université Paris-Saclay, INRAe, AgroParisTech, Micalis institute, Jouy-en-Josas, France.<br /><searchLink fieldCode="AU" term="%22Danne+C%22">Danne C</searchLink>; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.<br /><searchLink fieldCode="AU" term="%22Scandola+C%22">Scandola C</searchLink>; Institut Pasteur, Université Paris Cité, Ultrastructural Bioimaging Unit, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ledent+T%22">Ledent T</searchLink>; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.<br /><searchLink fieldCode="AU" term="%22Chevreux+G%22">Chevreux G</searchLink>; Université Paris Cité, CNRS, Institut Jacques Monod, Paris, France.<br /><searchLink fieldCode="AU" term="%22Argüello+RJ%22">Argüello RJ</searchLink>; Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.<br /><searchLink fieldCode="AU" term="%22De+Carvalho+Bittencourt+M%22">De Carvalho Bittencourt M</searchLink>; Université de Lorraine, CNRS, IMoPA, Nancy, France.; Université de Lorraine, CHRU Nancy, Immunology Department, Nancy, France.<br /><searchLink fieldCode="AU" term="%22Bettinger+J%22">Bettinger J</searchLink>; Université de Lorraine, CNRS, IMoPA, Nancy, France.<br /><searchLink fieldCode="AU" term="%22D'Aveni-Piney+M%22">D'Aveni-Piney M</searchLink>; Université de Lorraine, CNRS, IMoPA, Nancy, France.; Université de Lorraine, CHRU Nancy, Hematology Department, Nancy, France.<br /><searchLink fieldCode="AU" term="%22Moulin+D%22">Moulin D</searchLink>; Université de Lorraine, CNRS, IMoPA, Nancy, France.<br /><searchLink fieldCode="AU" term="%22Schreiber+S%22">Schreiber S</searchLink>; Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.; Department of Internal Medicine I, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Aden+K%22">Aden K</searchLink>; Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.; Department of Internal Medicine I, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Rolhion+N%22">Rolhion N</searchLink>; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.<br /><searchLink fieldCode="AU" term="%22Michel+ML%22">Michel ML</searchLink>; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.; Université Paris-Saclay, INRAe, AgroParisTech, Micalis institute, Jouy-en-Josas, France.<br /><searchLink fieldCode="AU" term="%22Wai+T%22">Wai T</searchLink>; Institut Pasteur, Mitochondrial Biology Unit, CNRS UMR 3691, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Sokol+H%22">Sokol H</searchLink>; Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France. harry.sokol@gmail.com.; Gut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France. harry.sokol@gmail.com.; Université Paris-Saclay, INRAe, AgroParisTech, Micalis institute, Jouy-en-Josas, France. harry.sokol@gmail.com.; Gastroenterology department, Saint Antoine Hospital, APHP, Paris, France. harry.sokol@gmail.com.
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