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Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment: The PINES Randomized Clinical Trial.

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Title: Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment: The PINES Randomized Clinical Trial.
Authors: Shimano KA; UCSF Benioff Children's Hospitals, San Francisco., Grimes AB; Texas Children's Cancer and Hematology Center, Houston.; Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Kaicker S; Weill Cornell Medicine/NewYork Presbyterian-Weill Cornell Medical College, New York, New York., Shah SJ; Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona.; Department of Child Health, College of Medicine, University of Arizona, Phoenix., Gunn E; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia.; Department of Pediatrics, Emory University, Atlanta, Georgia., Bhat RV; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.; Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Kochhar M; Hasbro Children's Hospital, Providence, Rhode Island.; Warren Alpert Medical School, Brown University, Providence, Rhode Island., Rothman JA; Duke University Medical Center, Durham, North Carolina., Rose MJ; Nationwide Children's Hospital, Columbus, Ohio.; College of Medicine, Ohio State University, Columbus., Briones M; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia., Nakano TA; Children's Hospital Colorado, Aurora., Lebensburger JD; University of Alabama at Birmingham., Lambert MP; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Perelman School of Medicine, University of Pennsylvania, Philadelphia., Fritch Lilla SA; Children's Minnesota, Minneapolis., Jesudas R; St Jude Children's Research Hospital, Memphis, Tennessee., Lee-Miller CA; School of Medicine and Public Health, University of Wisconsin, Madison.; American Family Children's Hospital, Madison, Wisconsin., Thompson AA; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Perelman School of Medicine, University of Pennsylvania, Philadelphia., Rifkin-Zenenberg S; Hackensack University Medical Center, Hackensack, New Jersey., Majumdar S; Children's National Medical Center, Washington, DC., Crary SE; University of Arkansas for Medical Sciences, Little Rock., Hege K; Riley Hospital for Children, Indianapolis, Indiana.; School of Medicine, Indiana University, Indianapolis., Ford JB; Primary Children's Hospital, Salt Lake City, Utah.; School of Medicine, University of Utah, Salt Lake City., Bies JJ; University of Nebraska Medical Center, Omaha., Fort J; College of Medicine, University of Florida, Gainesville., Wynn TT; College of Medicine, University of Florida, Gainesville., Hsieh L; Rady Children's Health, Orange, California., Ruiz ME; Rady Children's Health, Orange, California., Dinu B; Texas Children's Cancer and Hematology Center, Houston.; Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Wong JMW; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute, Cambridge, Massachusetts.; Harvard Medical School, Harvard University, Boston, Massachusetts., Kao PC; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Harvard Medical School, Harvard University, Boston, Massachusetts., Kim TO; Children's Hospital Los Angeles, Los Angeles, California.; Keck School of Medicine, University of Southern California, Los Angeles., Arnold SD; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia., Bennett CM; Pharmaceutical Systems Inc Contract Research Organization (PSI CRO), King of Prussia, Pennsylvania., Despotovic JM; Agios Pharmaceuticals, Cambridge, Massachusetts., Klaassen RJ; CHEO (Children's Hospital of Eastern Ontario) Research Institute, Ottawa, Ontario, Canada., Neufeld EJ; St Jude Children's Research Hospital, Memphis, Tennessee., Neunert CE; NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, New York.; Irving Medical Center, Columbia University, New York, New York., London WB; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Harvard Medical School, Harvard University, Boston, Massachusetts., Grace RF; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Harvard Medical School, Harvard University, Boston, Massachusetts.
Source: JAMA [JAMA] 2025 Nov 25; Vol. 334 (20), pp. 1816-1826.
Publication Type: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1538-3598
DOI:10.1001/jama.2025.18168