View in EDS HTML Full Text PDF Full Text

Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment: The PINES Randomized Clinical Trial.

Saved in:
Bibliographic Details
Title: Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment: The PINES Randomized Clinical Trial.
Authors: Shimano KA; UCSF Benioff Children's Hospitals, San Francisco., Grimes AB; Texas Children's Cancer and Hematology Center, Houston.; Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Kaicker S; Weill Cornell Medicine/NewYork Presbyterian-Weill Cornell Medical College, New York, New York., Shah SJ; Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona.; Department of Child Health, College of Medicine, University of Arizona, Phoenix., Gunn E; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia.; Department of Pediatrics, Emory University, Atlanta, Georgia., Bhat RV; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.; Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Kochhar M; Hasbro Children's Hospital, Providence, Rhode Island.; Warren Alpert Medical School, Brown University, Providence, Rhode Island., Rothman JA; Duke University Medical Center, Durham, North Carolina., Rose MJ; Nationwide Children's Hospital, Columbus, Ohio.; College of Medicine, Ohio State University, Columbus., Briones M; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia., Nakano TA; Children's Hospital Colorado, Aurora., Lebensburger JD; University of Alabama at Birmingham., Lambert MP; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Perelman School of Medicine, University of Pennsylvania, Philadelphia., Fritch Lilla SA; Children's Minnesota, Minneapolis., Jesudas R; St Jude Children's Research Hospital, Memphis, Tennessee., Lee-Miller CA; School of Medicine and Public Health, University of Wisconsin, Madison.; American Family Children's Hospital, Madison, Wisconsin., Thompson AA; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Perelman School of Medicine, University of Pennsylvania, Philadelphia., Rifkin-Zenenberg S; Hackensack University Medical Center, Hackensack, New Jersey., Majumdar S; Children's National Medical Center, Washington, DC., Crary SE; University of Arkansas for Medical Sciences, Little Rock., Hege K; Riley Hospital for Children, Indianapolis, Indiana.; School of Medicine, Indiana University, Indianapolis., Ford JB; Primary Children's Hospital, Salt Lake City, Utah.; School of Medicine, University of Utah, Salt Lake City., Bies JJ; University of Nebraska Medical Center, Omaha., Fort J; College of Medicine, University of Florida, Gainesville., Wynn TT; College of Medicine, University of Florida, Gainesville., Hsieh L; Rady Children's Health, Orange, California., Ruiz ME; Rady Children's Health, Orange, California., Dinu B; Texas Children's Cancer and Hematology Center, Houston.; Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Wong JMW; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute, Cambridge, Massachusetts.; Harvard Medical School, Harvard University, Boston, Massachusetts., Kao PC; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Harvard Medical School, Harvard University, Boston, Massachusetts., Kim TO; Children's Hospital Los Angeles, Los Angeles, California.; Keck School of Medicine, University of Southern California, Los Angeles., Arnold SD; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia., Bennett CM; Pharmaceutical Systems Inc Contract Research Organization (PSI CRO), King of Prussia, Pennsylvania., Despotovic JM; Agios Pharmaceuticals, Cambridge, Massachusetts., Klaassen RJ; CHEO (Children's Hospital of Eastern Ontario) Research Institute, Ottawa, Ontario, Canada., Neufeld EJ; St Jude Children's Research Hospital, Memphis, Tennessee., Neunert CE; NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, New York.; Irving Medical Center, Columbia University, New York, New York., London WB; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Harvard Medical School, Harvard University, Boston, Massachusetts., Grace RF; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Harvard Medical School, Harvard University, Boston, Massachusetts.
Source: JAMA [JAMA] 2025 Nov 25; Vol. 334 (20), pp. 1816-1826.
Publication Type: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41123939
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment: The PINES Randomized Clinical Trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Shimano+KA%22">Shimano KA</searchLink>; UCSF Benioff Children's Hospitals, San Francisco.<br /><searchLink fieldCode="AU" term="%22Grimes+AB%22">Grimes AB</searchLink>; Texas Children's Cancer and Hematology Center, Houston.; Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Kaicker+S%22">Kaicker S</searchLink>; Weill Cornell Medicine/NewYork Presbyterian-Weill Cornell Medical College, New York, New York.<br /><searchLink fieldCode="AU" term="%22Shah+SJ%22">Shah SJ</searchLink>; Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona.; Department of Child Health, College of Medicine, University of Arizona, Phoenix.<br /><searchLink fieldCode="AU" term="%22Gunn+E%22">Gunn E</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia.; Department of Pediatrics, Emory University, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Bhat+RV%22">Bhat RV</searchLink>; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.; Feinberg School of Medicine, Northwestern University, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Kochhar+M%22">Kochhar M</searchLink>; Hasbro Children's Hospital, Providence, Rhode Island.; Warren Alpert Medical School, Brown University, Providence, Rhode Island.<br /><searchLink fieldCode="AU" term="%22Rothman+JA%22">Rothman JA</searchLink>; Duke University Medical Center, Durham, North Carolina.<br /><searchLink fieldCode="AU" term="%22Rose+MJ%22">Rose MJ</searchLink>; Nationwide Children's Hospital, Columbus, Ohio.; College of Medicine, Ohio State University, Columbus.<br /><searchLink fieldCode="AU" term="%22Briones+M%22">Briones M</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Nakano+TA%22">Nakano TA</searchLink>; Children's Hospital Colorado, Aurora.<br /><searchLink fieldCode="AU" term="%22Lebensburger+JD%22">Lebensburger JD</searchLink>; University of Alabama at Birmingham.<br /><searchLink fieldCode="AU" term="%22Lambert+MP%22">Lambert MP</searchLink>; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Perelman School of Medicine, University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Fritch+Lilla+SA%22">Fritch Lilla SA</searchLink>; Children's Minnesota, Minneapolis.<br /><searchLink fieldCode="AU" term="%22Jesudas+R%22">Jesudas R</searchLink>; St Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Lee-Miller+CA%22">Lee-Miller CA</searchLink>; School of Medicine and Public Health, University of Wisconsin, Madison.; American Family Children's Hospital, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Thompson+AA%22">Thompson AA</searchLink>; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Perelman School of Medicine, University of Pennsylvania, Philadelphia.<br /><searchLink fieldCode="AU" term="%22Rifkin-Zenenberg+S%22">Rifkin-Zenenberg S</searchLink>; Hackensack University Medical Center, Hackensack, New Jersey.<br /><searchLink fieldCode="AU" term="%22Majumdar+S%22">Majumdar S</searchLink>; Children's National Medical Center, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Crary+SE%22">Crary SE</searchLink>; University of Arkansas for Medical Sciences, Little Rock.<br /><searchLink fieldCode="AU" term="%22Hege+K%22">Hege K</searchLink>; Riley Hospital for Children, Indianapolis, Indiana.; School of Medicine, Indiana University, Indianapolis.<br /><searchLink fieldCode="AU" term="%22Ford+JB%22">Ford JB</searchLink>; Primary Children's Hospital, Salt Lake City, Utah.; School of Medicine, University of Utah, Salt Lake City.<br /><searchLink fieldCode="AU" term="%22Bies+JJ%22">Bies JJ</searchLink>; University of Nebraska Medical Center, Omaha.<br /><searchLink fieldCode="AU" term="%22Fort+J%22">Fort J</searchLink>; College of Medicine, University of Florida, Gainesville.<br /><searchLink fieldCode="AU" term="%22Wynn+TT%22">Wynn TT</searchLink>; College of Medicine, University of Florida, Gainesville.<br /><searchLink fieldCode="AU" term="%22Hsieh+L%22">Hsieh L</searchLink>; Rady Children's Health, Orange, California.<br /><searchLink fieldCode="AU" term="%22Ruiz+ME%22">Ruiz ME</searchLink>; Rady Children's Health, Orange, California.<br /><searchLink fieldCode="AU" term="%22Dinu+B%22">Dinu B</searchLink>; Texas Children's Cancer and Hematology Center, Houston.; Division of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Wong+JMW%22">Wong JMW</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Broad Institute, Cambridge, Massachusetts.; Harvard Medical School, Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Kao+PC%22">Kao PC</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Harvard Medical School, Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Kim+TO%22">Kim TO</searchLink>; Children's Hospital Los Angeles, Los Angeles, California.; Keck School of Medicine, University of Southern California, Los Angeles.<br /><searchLink fieldCode="AU" term="%22Arnold+SD%22">Arnold SD</searchLink>; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Bennett+CM%22">Bennett CM</searchLink>; Pharmaceutical Systems Inc Contract Research Organization (PSI CRO), King of Prussia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Despotovic+JM%22">Despotovic JM</searchLink>; Agios Pharmaceuticals, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Klaassen+RJ%22">Klaassen RJ</searchLink>; CHEO (Children's Hospital of Eastern Ontario) Research Institute, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Neufeld+EJ%22">Neufeld EJ</searchLink>; St Jude Children's Research Hospital, Memphis, Tennessee.<br /><searchLink fieldCode="AU" term="%22Neunert+CE%22">Neunert CE</searchLink>; NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, New York.; Irving Medical Center, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22London+WB%22">London WB</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Harvard Medical School, Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Grace+RF%22">Grace RF</searchLink>; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts.; Harvard Medical School, Harvard University, Boston, Massachusetts.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%227501160%22">JAMA</searchLink> [JAMA] 2025 Nov 25; Vol. 334 (20), pp. 1816-1826.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Medical+Association%22">American Medical Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7501160 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-3598 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200987484%22">00987484 </searchLink><i>NLM ISO Abbreviation: </i>JAMA <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41123939
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1001/jama.2025.18168
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1816
    Titles:
      – TitleFull: Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment: The PINES Randomized Clinical Trial.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Shimano KA
      – PersonEntity:
          Name:
            NameFull: Grimes AB
      – PersonEntity:
          Name:
            NameFull: Kaicker S
      – PersonEntity:
          Name:
            NameFull: Shah SJ
      – PersonEntity:
          Name:
            NameFull: Gunn E
      – PersonEntity:
          Name:
            NameFull: Bhat RV
      – PersonEntity:
          Name:
            NameFull: Kochhar M
      – PersonEntity:
          Name:
            NameFull: Rothman JA
      – PersonEntity:
          Name:
            NameFull: Rose MJ
      – PersonEntity:
          Name:
            NameFull: Briones M
      – PersonEntity:
          Name:
            NameFull: Nakano TA
      – PersonEntity:
          Name:
            NameFull: Lebensburger JD
      – PersonEntity:
          Name:
            NameFull: Lambert MP
      – PersonEntity:
          Name:
            NameFull: Fritch Lilla SA
      – PersonEntity:
          Name:
            NameFull: Jesudas R
      – PersonEntity:
          Name:
            NameFull: Lee-Miller CA
      – PersonEntity:
          Name:
            NameFull: Thompson AA
      – PersonEntity:
          Name:
            NameFull: Rifkin-Zenenberg S
      – PersonEntity:
          Name:
            NameFull: Majumdar S
      – PersonEntity:
          Name:
            NameFull: Crary SE
      – PersonEntity:
          Name:
            NameFull: Hege K
      – PersonEntity:
          Name:
            NameFull: Ford JB
      – PersonEntity:
          Name:
            NameFull: Bies JJ
      – PersonEntity:
          Name:
            NameFull: Fort J
      – PersonEntity:
          Name:
            NameFull: Wynn TT
      – PersonEntity:
          Name:
            NameFull: Hsieh L
      – PersonEntity:
          Name:
            NameFull: Ruiz ME
      – PersonEntity:
          Name:
            NameFull: Dinu B
      – PersonEntity:
          Name:
            NameFull: Wong JMW
      – PersonEntity:
          Name:
            NameFull: Kao PC
      – PersonEntity:
          Name:
            NameFull: Kim TO
      – PersonEntity:
          Name:
            NameFull: Arnold SD
      – PersonEntity:
          Name:
            NameFull: Bennett CM
      – PersonEntity:
          Name:
            NameFull: Despotovic JM
      – PersonEntity:
          Name:
            NameFull: Klaassen RJ
      – PersonEntity:
          Name:
            NameFull: Neufeld EJ
      – PersonEntity:
          Name:
            NameFull: Neunert CE
      – PersonEntity:
          Name:
            NameFull: London WB
      – PersonEntity:
          Name:
            NameFull: Grace RF
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 25
              M: 11
              Text: 2025 Nov 25
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1538-3598
          Numbering:
            – Type: volume
              Value: 334
            – Type: issue
              Value: 20
          Titles:
            – TitleFull: JAMA
              Type: main
ResultId 1