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Engineering oncolytic bacteria as precision cancer therapeutics: design principles, therapeutic strategies, and translational perspectives.

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Title: Engineering oncolytic bacteria as precision cancer therapeutics: design principles, therapeutic strategies, and translational perspectives.
Authors: Niu L; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, Shanghai Academy of Natural Sciences (SANS), East China Normal University, Shanghai 200241, China., Deng Z; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, Shanghai Academy of Natural Sciences (SANS), East China Normal University, Shanghai 200241, China., Jin Y; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, Shanghai Academy of Natural Sciences (SANS), East China Normal University, Shanghai 200241, China., Guan N; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, Shanghai Academy of Natural Sciences (SANS), East China Normal University, Shanghai 200241, China.; Shanghai SynBioEra Biotechnology Co., Ltd., Shanghai 200241, China., Ye H; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, Shanghai Academy of Natural Sciences (SANS), East China Normal University, Shanghai 200241, China.; Shanghai SynBioEra Biotechnology Co., Ltd., Shanghai 200241, China.
Source: Protein & cell [Protein Cell] 2026 Apr 01; Vol. 17 (4), pp. 279-303.
Publication Type: Journal Article; Review
Journal Info: Publisher: Oxford University Press Country of Publication: Germany NLM ID: 101532368 Publication Model: Print Cited Medium: Internet ISSN: 1674-8018 (Electronic) Linking ISSN: 1674800X NLM ISO Abbreviation: Protein Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Engineering oncolytic bacteria as precision cancer therapeutics: design principles, therapeutic strategies, and translational perspectives.
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  Data: <searchLink fieldCode="AU" term="%22Niu+L%22">Niu L</searchLink>; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, Shanghai Academy of Natural Sciences (SANS), East China Normal University, Shanghai 200241, China.<br /><searchLink fieldCode="AU" term="%22Deng+Z%22">Deng Z</searchLink>; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, Shanghai Academy of Natural Sciences (SANS), East China Normal University, Shanghai 200241, China.<br /><searchLink fieldCode="AU" term="%22Jin+Y%22">Jin Y</searchLink>; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, Shanghai Academy of Natural Sciences (SANS), East China Normal University, Shanghai 200241, China.<br /><searchLink fieldCode="AU" term="%22Guan+N%22">Guan N</searchLink>; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, Shanghai Academy of Natural Sciences (SANS), East China Normal University, Shanghai 200241, China.; Shanghai SynBioEra Biotechnology Co., Ltd., Shanghai 200241, China.<br /><searchLink fieldCode="AU" term="%22Ye+H%22">Ye H</searchLink>; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, Shanghai Academy of Natural Sciences (SANS), East China Normal University, Shanghai 200241, China.; Shanghai SynBioEra Biotechnology Co., Ltd., Shanghai 200241, China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101532368 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1674-8018 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221674800X%22">1674800X </searchLink><i>NLM ISO Abbreviation: </i>Protein Cell <i>Subsets: </i>MEDLINE
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1093/procel/pwaf085
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      – Code: eng
        Text: English
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        StartPage: 279
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      – TitleFull: Engineering oncolytic bacteria as precision cancer therapeutics: design principles, therapeutic strategies, and translational perspectives.
        Type: main
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          Name:
            NameFull: Niu L
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          Name:
            NameFull: Deng Z
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            NameFull: Jin Y
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            NameFull: Guan N
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            NameFull: Ye H
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            – D: 01
              M: 04
              Text: 2026 Apr 01
              Type: published
              Y: 2026
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              Value: 1674-8018
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              Value: 17
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Protein & cell
              Type: main
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