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Rapid and Sustained Response of Biochemically Uncontrolled Acromegaly to Once-daily Oral Paltusotine Treatment.

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Title: Rapid and Sustained Response of Biochemically Uncontrolled Acromegaly to Once-daily Oral Paltusotine Treatment.
Authors: Biller BMK; Neuroendocrine and Pituitary Tumor Clinical Center, Massachusetts General Hospital, Boston, MA 02114, USA., Casagrande A; Crinetics Pharmaceuticals, Inc, San Diego, CA 92121, USA., Elenkova A; Department of Endocrinology, Medical University-Sofia, USHATE 'Acad. Ivan Penchev', Sofia 1431, Bulgaria., Boguszewski CL; Department of Internal Medicine, Endocrine Division (SEMPR), Federal University of Paraná, Curitiba 80030-110, Brazil., Jallad RS; Neuroendocrine Unit, Division of Endocrinology and Metabolism, Clinics Hospital, University of São Paulo Medical School, São Paulo 01246-903, Brazil., Hu B; Crinetics Pharmaceuticals, Inc, San Diego, CA 92121, USA., Hubina E; 2nd Department of Internal Medicine, Division of Endocrinology, Central Hospital of Northern Pest-Military Hospital, Budapest 1134, Hungary., Fazeli PK; Neuroendocrinology Unit, Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Fleseriu M; Pituitary Center, Departments of Medicine and Neurological Surgery, Oregon Health and Science University, Portland, OR 97239, USA., Snyder PJ; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Strasburger CJ; Department of Medicine for Endocrinology and Metabolism, Charité Universitaetsmedizin, Campus Mitte, Berlin 10117, Germany., Bidlingmaier M; Medizinische Klinik und Poliklinik IV, LMU Klinikum, Munich 80336, Germany., Zhao Y; Department of Neurosurgery, University Hospital Erlangen, Erlangen 91054, Germany., Soares B; Department of Internal Medicine, Medical School of the Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil., Trainer PJ; Crinetics Pharmaceuticals, Inc, San Diego, CA 92121, USA., Struthers RS; Crinetics Pharmaceuticals, Inc, San Diego, CA 92121, USA., Krasner A; Crinetics Pharmaceuticals, Inc, San Diego, CA 92121, USA., Gadelha MR; Neuroendocrinology Research Center/Endocrinology Division, Medical School and Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
Source: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2026 Mar 17; Vol. 111 (4), pp. e1050-e1063.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Rapid and Sustained Response of Biochemically Uncontrolled Acromegaly to Once-daily Oral Paltusotine Treatment.
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  Data: <searchLink fieldCode="AU" term="%22Biller+BMK%22">Biller BMK</searchLink>; Neuroendocrine and Pituitary Tumor Clinical Center, Massachusetts General Hospital, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Casagrande+A%22">Casagrande A</searchLink>; Crinetics Pharmaceuticals, Inc, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Elenkova+A%22">Elenkova A</searchLink>; Department of Endocrinology, Medical University-Sofia, USHATE 'Acad. Ivan Penchev', Sofia 1431, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Boguszewski+CL%22">Boguszewski CL</searchLink>; Department of Internal Medicine, Endocrine Division (SEMPR), Federal University of Paraná, Curitiba 80030-110, Brazil.<br /><searchLink fieldCode="AU" term="%22Jallad+RS%22">Jallad RS</searchLink>; Neuroendocrine Unit, Division of Endocrinology and Metabolism, Clinics Hospital, University of São Paulo Medical School, São Paulo 01246-903, Brazil.<br /><searchLink fieldCode="AU" term="%22Hu+B%22">Hu B</searchLink>; Crinetics Pharmaceuticals, Inc, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Hubina+E%22">Hubina E</searchLink>; 2nd Department of Internal Medicine, Division of Endocrinology, Central Hospital of Northern Pest-Military Hospital, Budapest 1134, Hungary.<br /><searchLink fieldCode="AU" term="%22Fazeli+PK%22">Fazeli PK</searchLink>; Neuroendocrinology Unit, Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.<br /><searchLink fieldCode="AU" term="%22Fleseriu+M%22">Fleseriu M</searchLink>; Pituitary Center, Departments of Medicine and Neurological Surgery, Oregon Health and Science University, Portland, OR 97239, USA.<br /><searchLink fieldCode="AU" term="%22Snyder+PJ%22">Snyder PJ</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Strasburger+CJ%22">Strasburger CJ</searchLink>; Department of Medicine for Endocrinology and Metabolism, Charité Universitaetsmedizin, Campus Mitte, Berlin 10117, Germany.<br /><searchLink fieldCode="AU" term="%22Bidlingmaier+M%22">Bidlingmaier M</searchLink>; Medizinische Klinik und Poliklinik IV, LMU Klinikum, Munich 80336, Germany.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of Neurosurgery, University Hospital Erlangen, Erlangen 91054, Germany.<br /><searchLink fieldCode="AU" term="%22Soares+B%22">Soares B</searchLink>; Department of Internal Medicine, Medical School of the Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.<br /><searchLink fieldCode="AU" term="%22Trainer+PJ%22">Trainer PJ</searchLink>; Crinetics Pharmaceuticals, Inc, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Struthers+RS%22">Struthers RS</searchLink>; Crinetics Pharmaceuticals, Inc, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Krasner+A%22">Krasner A</searchLink>; Crinetics Pharmaceuticals, Inc, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Gadelha+MR%22">Gadelha MR</searchLink>; Neuroendocrinology Research Center/Endocrinology Division, Medical School and Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
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