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LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies.

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Title: LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies.
Authors: Buck SA; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA., Malankhanova T; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA., Strader S; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA., Ma EB; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA., Yim S; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA., Pratt HW; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA., Ervin J; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke/UNC Alzheimer's Disease Research Center, Durham, NC, 27710, USA., Lee EB; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Wang SJ; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke/UNC Alzheimer's Disease Research Center, Durham, NC, 27710, USA., Cohen TJ; Department of Neurology, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 27599, USA.; UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC, 27599, USA., West AB; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA., Sanders LH; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA. laurie.sanders@duke.edu.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA. laurie.sanders@duke.edu.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA. laurie.sanders@duke.edu.
Source: Acta neuropathologica [Acta Neuropathol] 2025 Oct 23; Vol. 150 (1), pp. 44. Date of Electronic Publication: 2025 Oct 23.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies.
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  Data: <searchLink fieldCode="AU" term="%22Buck+SA%22">Buck SA</searchLink>; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Malankhanova+T%22">Malankhanova T</searchLink>; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Strader+S%22">Strader S</searchLink>; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Ma+EB%22">Ma EB</searchLink>; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Yim+S%22">Yim S</searchLink>; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Pratt+HW%22">Pratt HW</searchLink>; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Ervin+J%22">Ervin J</searchLink>; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke/UNC Alzheimer's Disease Research Center, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Lee+EB%22">Lee EB</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.<br /><searchLink fieldCode="AU" term="%22Wang+SJ%22">Wang SJ</searchLink>; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke/UNC Alzheimer's Disease Research Center, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+TJ%22">Cohen TJ</searchLink>; Department of Neurology, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, 27599, USA.; UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC, 27599, USA.<br /><searchLink fieldCode="AU" term="%22West+AB%22">West AB</searchLink>; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA.<br /><searchLink fieldCode="AU" term="%22Sanders+LH%22">Sanders LH</searchLink>; Department of Neurology, Duke University School of Medicine, Durham, NC, 27710, USA. laurie.sanders@duke.edu.; Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA. laurie.sanders@duke.edu.; Duke Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC, 27710, USA. laurie.sanders@duke.edu.
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  Data: <searchLink fieldCode="JN" term="%220412041%22">Acta neuropathologica</searchLink> [Acta Neuropathol] 2025 Oct 23; Vol. 150 (1), pp. 44. <i>Date of Electronic Publication: </i>2025 Oct 23.
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