A Multitrait Polygenic Risk Score for Open-Angle Glaucoma Stratifies Risk of Pigmentary Glaucoma in Pigment Dispersion Syndrome.

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Title: A Multitrait Polygenic Risk Score for Open-Angle Glaucoma Stratifies Risk of Pigmentary Glaucoma in Pigment Dispersion Syndrome.
Authors: Kolovos A; Flinders Eye and Vision, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia; Department of Ophthalmology, Flinders Medical Centre, Adelaide, South Australia, Australia. Electronic address: antonia.kolovos@flinders.edu.au., Qassim A; Flinders Eye and Vision, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia; Department of Ophthalmology, Flinders Medical Centre, Adelaide, South Australia, Australia., Marshall HN; Flinders Eye and Vision, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia., Nguyen TT; Flinders Eye and Vision, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia; Department of Ophthalmology, Flinders Medical Centre, Adelaide, South Australia, Australia., Schmidt J; Flinders Eye and Vision, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia., Hassall MM; Flinders Eye and Vision, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia; Department of Ophthalmology, Flinders Medical Centre, Adelaide, South Australia, Australia., Tang V; Flinders Eye and Vision, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia., Maxwell G; Flinders Eye and Vision, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia., Landers J; Flinders Eye and Vision, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia; Department of Ophthalmology, Flinders Medical Centre, Adelaide, South Australia, Australia., Mills R; Flinders Eye and Vision, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia; Department of Ophthalmology, Flinders Medical Centre, Adelaide, South Australia, Australia., Lake S; Flinders Eye and Vision, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia; Department of Ophthalmology, Flinders Medical Centre, Adelaide, South Australia, Australia., Graham SL; Faculty of Medicine, Health and Human Sciences, Ophthalmology and Vision Science, Macquarie University, Sydney, New South Wales, Australia., Schulz A; Faculty of Medicine, Health and Human Sciences, Ophthalmology and Vision Science, Macquarie University, Sydney, New South Wales, Australia., Galanopoulos A; Ophthalmic Research Laboratories, University of Adelaide, Adelaide Health and Medical Sciences Building, Adelaide, South Australia, Australia., Casson RJ; Ophthalmic Research Laboratories, University of Adelaide, Adelaide Health and Medical Sciences Building, Adelaide, South Australia, Australia., Goldberg I; Discipline of Ophthalmology, University of Sydney, Sydney Eye Hospital, Sydney, New South Wales, Australia., Coote M; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia., Best S; Eye Department, Greenlane Clinical Centre, Auckland District Health Board, Auckland, New Zealand., Lusthaus J; Discipline of Ophthalmology, University of Sydney, Sydney Eye Hospital, Sydney, New South Wales, Australia., Healey PR; Department of Ophthalmology, Centre for Vision Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia., Burnett L; Genomics and Inherited Diseases, Garvan Institute of Medical Research, Sydney, New South Wales, Australia; Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia., Töteberg-Harms M; Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Institute for Vision Research, University of Iowa, Iowa City, Iowa., Boese EA; Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Institute for Vision Research, University of Iowa, Iowa City, Iowa., Pouw AE; Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Institute for Vision Research, University of Iowa, Iowa City, Iowa., Gharahkhani P; Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Scheetz T; Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Institute for Vision Research, University of Iowa, Iowa City, Iowa., Hewitt AW; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Western Australia, Australia; Department of Ophthalmology, Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., MacGregor S; Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Siggs OM; Genomics and Inherited Diseases, Garvan Institute of Medical Research, Sydney, New South Wales, Australia; Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia., Souzeau E; Flinders Eye and Vision, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia., Fingert JH; Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Institute for Vision Research, University of Iowa, Iowa City, Iowa., Craig JE; Flinders Eye and Vision, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia; Department of Ophthalmology, Flinders Medical Centre, Adelaide, South Australia, Australia.
Source: Ophthalmology. Glaucoma [Ophthalmol Glaucoma] 2026 Mar-Apr; Vol. 9 (2), pp. 193-201. Date of Electronic Publication: 2025 Oct 21.
Publication Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101730510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-4196 (Electronic) Linking ISSN: 25894196 NLM ISO Abbreviation: Ophthalmol Glaucoma Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2589-4196
DOI:10.1016/j.ogla.2025.10.005