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Elucidating lipid nanoparticle properties and structure through biophysical analyses.

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Title: Elucidating lipid nanoparticle properties and structure through biophysical analyses.
Authors: Padilla MS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Shepherd SJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Hanna AR; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Kurnik M; Waters Corporation, Goleta, CA, USA., Zhang X; Waters Corporation, Goleta, CA, USA., Chen M; Waters Corporation, Goleta, CA, USA., Byrnes J; National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY, USA., Joseph RA; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Yamagata HM; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Ricciardi AS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Department of Surgery, University of Pennsylvania Health System, Philadelphia, PA, USA.; Center for Fetal Research, Division of General, Thoracic and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Mrksich K; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Issadore D; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.; Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA, USA., Gupta K; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. kgupta@pennmedicine.upenn.edu., Mitchell MJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.
Source: Nature biotechnology [Nat Biotechnol] 2025 Oct 23. Date of Electronic Publication: 2025 Oct 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Padilla+MS%22">Padilla MS</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Shepherd+SJ%22">Shepherd SJ</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hanna+AR%22">Hanna AR</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kurnik+M%22">Kurnik M</searchLink>; Waters Corporation, Goleta, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Waters Corporation, Goleta, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+M%22">Chen M</searchLink>; Waters Corporation, Goleta, CA, USA.<br /><searchLink fieldCode="AU" term="%22Byrnes+J%22">Byrnes J</searchLink>; National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY, USA.<br /><searchLink fieldCode="AU" term="%22Joseph+RA%22">Joseph RA</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Yamagata+HM%22">Yamagata HM</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ricciardi+AS%22">Ricciardi AS</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Department of Surgery, University of Pennsylvania Health System, Philadelphia, PA, USA.; Center for Fetal Research, Division of General, Thoracic and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mrksich+K%22">Mrksich K</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Issadore+D%22">Issadore D</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, USA.; Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+K%22">Gupta K</searchLink>; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. kgupta@pennmedicine.upenn.edu.<br /><searchLink fieldCode="AU" term="%22Mitchell+MJ%22">Mitchell MJ</searchLink>; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mjmitch@seas.upenn.edu.
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