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Association of Epigenetic Age Acceleration and Mitochondrial DNA-Based Aging Metrics Provides Insights Into Mechanisms of Aging-Related Diseases.

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Title: Association of Epigenetic Age Acceleration and Mitochondrial DNA-Based Aging Metrics Provides Insights Into Mechanisms of Aging-Related Diseases.
Authors: Wang M; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Zheng Y; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Lai M; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; Faculty of Computing & Data Sciences, Boston University, Boston, Massachusetts, USA., Saake E; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; Bioinformatics Program, Faculty of Computing and Data Science, Boston University, Boston, Massachusetts, USA., Liu X; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, California, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, California, USA., Huan T; Population Sciences Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Maryland, USA., Joehanes R; Population Sciences Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Maryland, USA., Nannini DR; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Zhang K; Department of Environmental Health Sciences, College of Integrated Health Sciences, University at Albany, State University of New York, Rensselaer, New York, USA., Lake NJ; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, USA., Castellani CA; Departments of Pathology and Laboratory Medicine & Epidemiology and Biostatistics, Western University, London, Ontario, Canada.; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Rich SS; Department of Genome Sciences, University of Virginia, Charlottesville, Virginia, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, California, USA., Liu Y; Divisions of Cardiology and Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Carson AP; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA., Fornage M; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Ma J; Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Hou L; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Levy D; Population Sciences Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Maryland, USA.; Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, USA., Liu C; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, USA.
Source: Aging cell [Aging Cell] 2025 Dec; Vol. 24 (12), pp. e70279. Date of Electronic Publication: 2025 Oct 24.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
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  Data: Association of Epigenetic Age Acceleration and Mitochondrial DNA-Based Aging Metrics Provides Insights Into Mechanisms of Aging-Related Diseases.
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  Data: <searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+Y%22">Zheng Y</searchLink>; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Lai+M%22">Lai M</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; Faculty of Computing & Data Sciences, Boston University, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Saake+E%22">Saake E</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; Bioinformatics Program, Faculty of Computing and Data Science, Boston University, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, California, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+KD%22">Taylor KD</searchLink>; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, California, USA.<br /><searchLink fieldCode="AU" term="%22Huan+T%22">Huan T</searchLink>; Population Sciences Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Joehanes+R%22">Joehanes R</searchLink>; Population Sciences Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Nannini+DR%22">Nannini DR</searchLink>; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+K%22">Zhang K</searchLink>; Department of Environmental Health Sciences, College of Integrated Health Sciences, University at Albany, State University of New York, Rensselaer, New York, USA.<br /><searchLink fieldCode="AU" term="%22Lake+NJ%22">Lake NJ</searchLink>; Department of Genetics, Yale School of Medicine, New Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Castellani+CA%22">Castellani CA</searchLink>; Departments of Pathology and Laboratory Medicine & Epidemiology and Biostatistics, Western University, London, Ontario, Canada.; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Rich+SS%22">Rich SS</searchLink>; Department of Genome Sciences, University of Virginia, Charlottesville, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Rotter+JI%22">Rotter JI</searchLink>; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, California, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Divisions of Cardiology and Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Raffield+LM%22">Raffield LM</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Carson+AP%22">Carson AP</searchLink>; Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.<br /><searchLink fieldCode="AU" term="%22Fornage+M%22">Fornage M</searchLink>; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Arking+DE%22">Arking DE</searchLink>; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Hou+L%22">Hou L</searchLink>; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Levy+D%22">Levy D</searchLink>; Population Sciences Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Maryland, USA.; Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.; Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, USA.
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