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Pharmacokinetics and tolerability of single-dose Staccato® alprazolam in adolescents with epilepsy, and population pharmacokinetic analysis to support dose selection in adolescents.

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Title: Pharmacokinetics and tolerability of single-dose Staccato® alprazolam in adolescents with epilepsy, and population pharmacokinetic analysis to support dose selection in adolescents.
Authors: Klein P; Department of Epilepsy, Mid-Atlantic Epilepsy and Sleep Center, Bethesda, Maryland, USA., Aungaroon G; Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Biton V; Arkansas Epilepsy Program, Little Rock, Arkansas, USA., Liow KK; Comprehensive Epilepsy Center, Hawaii Pacific Neuroscience, Honolulu, Hawaii, USA., Phillips S; Department of Neurology, Mary Bridge Children's Hospital, MultiCare Institute for Research and Innovation, Tacoma, Washington, USA., Wychowski T; Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA., Sadek A; Research Institute of Orlando, Orlando, Florida, USA., Elshoff JP; Department of Global Clinical Development, UCB, Monheim am Rhein, Germany., Roebling R; Department of Global Clinical Development, UCB, Monheim am Rhein, Germany., King A; Department of Safety Risk Management, UCB, Smyrna, Georgia, USA., Rospo CC; Department of Precision Medicine, UCB, Braine-l'Alleud, Belgium., Schoemaker R; Occams Coöperatie U.A., Amstelveen, The Netherlands., Chanteux H; Department of Early Clinical Development & Translational Sciences, Patient Solutions, UCB, Braine-l'Alleud, Belgium.
Source: Epilepsia [Epilepsia] 2026 Jan; Vol. 67 (1), pp. 109-119. Date of Electronic Publication: 2025 Oct 24.
Publication Type: Journal Article; Multicenter Study; Clinical Trial, Phase I
Journal Info: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE
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  Data: Pharmacokinetics and tolerability of single-dose Staccato® alprazolam in adolescents with epilepsy, and population pharmacokinetic analysis to support dose selection in adolescents.
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  Data: <searchLink fieldCode="AU" term="%22Klein+P%22">Klein P</searchLink>; Department of Epilepsy, Mid-Atlantic Epilepsy and Sleep Center, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Aungaroon+G%22">Aungaroon G</searchLink>; Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Biton+V%22">Biton V</searchLink>; Arkansas Epilepsy Program, Little Rock, Arkansas, USA.<br /><searchLink fieldCode="AU" term="%22Liow+KK%22">Liow KK</searchLink>; Comprehensive Epilepsy Center, Hawaii Pacific Neuroscience, Honolulu, Hawaii, USA.<br /><searchLink fieldCode="AU" term="%22Phillips+S%22">Phillips S</searchLink>; Department of Neurology, Mary Bridge Children's Hospital, MultiCare Institute for Research and Innovation, Tacoma, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Wychowski+T%22">Wychowski T</searchLink>; Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA.<br /><searchLink fieldCode="AU" term="%22Sadek+A%22">Sadek A</searchLink>; Research Institute of Orlando, Orlando, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Elshoff+JP%22">Elshoff JP</searchLink>; Department of Global Clinical Development, UCB, Monheim am Rhein, Germany.<br /><searchLink fieldCode="AU" term="%22Roebling+R%22">Roebling R</searchLink>; Department of Global Clinical Development, UCB, Monheim am Rhein, Germany.<br /><searchLink fieldCode="AU" term="%22King+A%22">King A</searchLink>; Department of Safety Risk Management, UCB, Smyrna, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Rospo+CC%22">Rospo CC</searchLink>; Department of Precision Medicine, UCB, Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Schoemaker+R%22">Schoemaker R</searchLink>; Occams Coöperatie U.A., Amstelveen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Chanteux+H%22">Chanteux H</searchLink>; Department of Early Clinical Development & Translational Sciences, Patient Solutions, UCB, Braine-l'Alleud, Belgium.
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  Data: <searchLink fieldCode="JN" term="%222983306R%22">Epilepsia</searchLink> [Epilepsia] 2026 Jan; Vol. 67 (1), pp. 109-119. <i>Date of Electronic Publication: </i>2025 Oct 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Blackwell+Science%22">Blackwell Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2983306R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-1167 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200139580%22">00139580 </searchLink><i>NLM ISO Abbreviation: </i>Epilepsia <i>Subsets: </i>MEDLINE
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