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Development and validation of clinico-imaging machine learning and deep learning models to predict responses to initial antiseizure medications in epilepsy.

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Title: Development and validation of clinico-imaging machine learning and deep learning models to predict responses to initial antiseizure medications in epilepsy.
Authors: Nazem-Zadeh MR; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran., Chang RS; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, Alfred Health, Melbourne, Victoria, Australia., Barnard S; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia., Pardoe HR; Imaging and Epilepsy Group, Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia., Kuzniecky R; Northwell Health, New York City, New York, USA., Mishra D; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; School of Computer Science & Software Engineering, Monash University, Melbourne, Victoria, Australia., Kamkar H; Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran., Nhu D; Monash Medical AI, Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia.; Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia.; AIM for Health Lab, Monash University, Melbourne, Victoria, Australia., Metha D; Monash Medical AI, Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia.; Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia.; AIM for Health Lab, Monash University, Melbourne, Victoria, Australia., Thom D; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia., Chen Z; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia., Ge Z; Monash Medical AI, Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia.; Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia.; AIM for Health Lab, Monash University, Melbourne, Victoria, Australia.; Airdoc-Monash Research Lab, Monash University, Melbourne, Victoria, Australia., O'Brien TJ; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, Alfred Health, Melbourne, Victoria, Australia.; Department of Medicine & Neurology, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia., Sinclair B; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia., French J; Epilepsy Consortium, New York University Langone, New York City, New York, USA., Law M; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Department of Radiology, Alfred Health, Melbourne, Victoria, Australia.; Department of Electrical and Computer Systems Engineering, Monash University, Melbourne, Victoria, Australia., Kwan P; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, Alfred Health, Melbourne, Victoria, Australia.; Department of Medicine & Neurology, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Source: Epilepsia [Epilepsia] 2026 Jan; Vol. 67 (1), pp. 120-137. Date of Electronic Publication: 2025 Oct 24.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Nazem-Zadeh+MR%22">Nazem-Zadeh MR</searchLink>; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Chang+RS%22">Chang RS</searchLink>; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, Alfred Health, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Barnard+S%22">Barnard S</searchLink>; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Pardoe+HR%22">Pardoe HR</searchLink>; Imaging and Epilepsy Group, Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Kuzniecky+R%22">Kuzniecky R</searchLink>; Northwell Health, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Mishra+D%22">Mishra D</searchLink>; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; School of Computer Science & Software Engineering, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Kamkar+H%22">Kamkar H</searchLink>; Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Nhu+D%22">Nhu D</searchLink>; Monash Medical AI, Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia.; Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia.; AIM for Health Lab, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Metha+D%22">Metha D</searchLink>; Monash Medical AI, Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia.; Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia.; AIM for Health Lab, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Thom+D%22">Thom D</searchLink>; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ge+Z%22">Ge Z</searchLink>; Monash Medical AI, Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia.; Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia.; AIM for Health Lab, Monash University, Melbourne, Victoria, Australia.; Airdoc-Monash Research Lab, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22O'Brien+TJ%22">O'Brien TJ</searchLink>; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, Alfred Health, Melbourne, Victoria, Australia.; Department of Medicine & Neurology, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Sinclair+B%22">Sinclair B</searchLink>; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22French+J%22">French J</searchLink>; Epilepsy Consortium, New York University Langone, New York City, New York, USA.<br /><searchLink fieldCode="AU" term="%22Law+M%22">Law M</searchLink>; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Department of Radiology, Alfred Health, Melbourne, Victoria, Australia.; Department of Electrical and Computer Systems Engineering, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Kwan+P%22">Kwan P</searchLink>; Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Department of Neurology, Alfred Health, Melbourne, Victoria, Australia.; Department of Medicine & Neurology, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
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  Data: <searchLink fieldCode="JN" term="%222983306R%22">Epilepsia</searchLink> [Epilepsia] 2026 Jan; Vol. 67 (1), pp. 120-137. <i>Date of Electronic Publication: </i>2025 Oct 24.
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