Mutant and Wild-Type RAS Cross-talk and Stoichiometric Deficiencies Are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma.
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| Title: | Mutant and Wild-Type RAS Cross-talk and Stoichiometric Deficiencies Are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma. |
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| Authors: | Kamgar M; Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., Hobbes GA; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina., Davidson R; Department of Biochemistry, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., Dorbin D; Department of Biochemistry, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., Herrera J; Department of Biochemistry, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., Langenheim JF; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Comprehensive Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania., Burge RA; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina., Aldakkak M; Department of Surgery, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., Conrardy RD; Data Science Institute, Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin., Szabo A; Data Science Institute, Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin., Thalji SZ; Department of Surgery, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., Mayer B; Department of Pharmacy, Froedtert Health, Milwaukee, Wisconsin., Grahl JJ; Department of Pharmacy, Froedtert Health, Milwaukee, Wisconsin., Chung BY; Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin., Phan A; Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., Thomas JP; Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., Seo YD; Department of Surgery, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., Evans DB; Department of Surgery, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., Christians KK; Department of Surgery, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., Erickson B; Department of Radiation Oncology, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., Hall WA; Department of Radiation Oncology, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., George B; Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., Tsai S; Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio., Lytle NK; Department of Surgery, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., Der CJ; Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Kurzrock R; Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin., McFall T; Department of Biochemistry, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.; Department of Surgery, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin. |
| Source: | Cancer research [Cancer Res] 2026 Apr 15; Vol. 86 (8), pp. 2042-2059. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41134578 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Mutant and Wild-Type RAS Cross-talk and Stoichiometric Deficiencies Are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Kamgar+M%22">Kamgar M</searchLink>; Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Hobbes+GA%22">Hobbes GA</searchLink>; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Davidson+R%22">Davidson R</searchLink>; Department of Biochemistry, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Dorbin+D%22">Dorbin D</searchLink>; Department of Biochemistry, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Herrera+J%22">Herrera J</searchLink>; Department of Biochemistry, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Langenheim+JF%22">Langenheim JF</searchLink>; Department of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.; Sidney Kimmel Comprehensive Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Burge+RA%22">Burge RA</searchLink>; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.<br /><searchLink fieldCode="AU" term="%22Aldakkak+M%22">Aldakkak M</searchLink>; Department of Surgery, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Conrardy+RD%22">Conrardy RD</searchLink>; Data Science Institute, Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Szabo+A%22">Szabo A</searchLink>; Data Science Institute, Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Thalji+SZ%22">Thalji SZ</searchLink>; Department of Surgery, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Mayer+B%22">Mayer B</searchLink>; Department of Pharmacy, Froedtert Health, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Grahl+JJ%22">Grahl JJ</searchLink>; Department of Pharmacy, Froedtert Health, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Chung+BY%22">Chung BY</searchLink>; Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Phan+A%22">Phan A</searchLink>; Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Thomas+JP%22">Thomas JP</searchLink>; Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Seo+YD%22">Seo YD</searchLink>; Department of Surgery, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Evans+DB%22">Evans DB</searchLink>; Department of Surgery, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Christians+KK%22">Christians KK</searchLink>; Department of Surgery, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Erickson+B%22">Erickson B</searchLink>; Department of Radiation Oncology, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Hall+WA%22">Hall WA</searchLink>; Department of Radiation Oncology, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22George+B%22">George B</searchLink>; Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Tsai+S%22">Tsai S</searchLink>; Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Lytle+NK%22">Lytle NK</searchLink>; Department of Surgery, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Der+CJ%22">Der CJ</searchLink>; Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Kurzrock+R%22">Kurzrock R</searchLink>; Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.<br /><searchLink fieldCode="AU" term="%22McFall+T%22">McFall T</searchLink>; Department of Biochemistry, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin.; Department of Surgery, Medical College of Wisconsin and the LaBahn Pancreatic Cancer Program, Milwaukee, Wisconsin. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%222984705R%22">Cancer research</searchLink> [Cancer Res] 2026 Apr 15; Vol. 86 (8), pp. 2042-2059. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2984705R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-7445 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200085472%22">00085472 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41134578 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1158/0008-5472.CAN-25-0018 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 2042 Titles: – TitleFull: Mutant and Wild-Type RAS Cross-talk and Stoichiometric Deficiencies Are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kamgar M – PersonEntity: Name: NameFull: Hobbes GA – PersonEntity: Name: NameFull: Davidson R – PersonEntity: Name: NameFull: Dorbin D – PersonEntity: Name: NameFull: Herrera J – PersonEntity: Name: NameFull: Langenheim JF – PersonEntity: Name: NameFull: Burge RA – PersonEntity: Name: NameFull: Aldakkak M – PersonEntity: Name: NameFull: Conrardy RD – PersonEntity: Name: NameFull: Szabo A – PersonEntity: Name: NameFull: Thalji SZ – PersonEntity: Name: NameFull: Mayer B – PersonEntity: Name: NameFull: Grahl JJ – PersonEntity: Name: NameFull: Chung BY – PersonEntity: Name: NameFull: Phan A – PersonEntity: Name: NameFull: Thomas JP – PersonEntity: Name: NameFull: Seo YD – PersonEntity: Name: NameFull: Evans DB – PersonEntity: Name: NameFull: Christians KK – PersonEntity: Name: NameFull: Erickson B – PersonEntity: Name: NameFull: Hall WA – PersonEntity: Name: NameFull: George B – PersonEntity: Name: NameFull: Tsai S – PersonEntity: Name: NameFull: Lytle NK – PersonEntity: Name: NameFull: Der CJ – PersonEntity: Name: NameFull: Kurzrock R – PersonEntity: Name: NameFull: McFall T IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 04 Text: 2026 Apr 15 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1538-7445 Numbering: – Type: volume Value: 86 – Type: issue Value: 8 Titles: – TitleFull: Cancer research Type: main |
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