The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice.

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Title: The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice.
Authors: In Het Panhuis W; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.; Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, Netherlands., Thiemann E; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., van Dijk DMAH; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Been B; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Jarrett KE; Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Meurs A; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Gastroenterology Endocrinology Metabolism and Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, Netherlands., Kooijman S; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Hovingh MV; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Modder M; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., van Os BW; Department of Medical Biochemistry, Amsterdam University Medical Centers, Amsterdam, Netherlands.; Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, Netherlands.; Amsterdam Immunity and Infection, Amsterdam, Netherlands., Sluiter TJ; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.; Department of Surgery, Leiden University Medical Center, Leiden, Netherlands., Blomberg N; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands., Pronk ACM; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Afkir S; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Streefland TCM; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Lalai RA; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Taveras MO; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Zhang S; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Adams TE; CSIRO Manufacturing, Clayton, Victoria, Australia., Terry LV; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Turpin-Nolan SM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., de Vries MR; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.; Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Giera M; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands., Rose-John S; Department of Biochemistry, Christian-Albrechts-Universität zu Kiel, Kiel, Germany., Zelcer N; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Gastroenterology Endocrinology Metabolism and Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, Netherlands., de Boer JF; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., de Aguiar Vallim TQ; Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Febbraio MA; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Rensen PCN; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Schönke M; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.
Source: Science advances [Sci Adv] 2025 Oct 24; Vol. 11 (43), pp. eadx3794. Date of Electronic Publication: 2025 Oct 24.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2375-2548
DOI:10.1126/sciadv.adx3794