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The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice.

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Title: The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice.
Authors: In Het Panhuis W; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.; Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, Netherlands., Thiemann E; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., van Dijk DMAH; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Been B; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Jarrett KE; Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Meurs A; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Gastroenterology Endocrinology Metabolism and Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, Netherlands., Kooijman S; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Hovingh MV; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., Modder M; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., van Os BW; Department of Medical Biochemistry, Amsterdam University Medical Centers, Amsterdam, Netherlands.; Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, Netherlands.; Amsterdam Immunity and Infection, Amsterdam, Netherlands., Sluiter TJ; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.; Department of Surgery, Leiden University Medical Center, Leiden, Netherlands., Blomberg N; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands., Pronk ACM; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Afkir S; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Streefland TCM; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Lalai RA; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Taveras MO; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Zhang S; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Adams TE; CSIRO Manufacturing, Clayton, Victoria, Australia., Terry LV; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Turpin-Nolan SM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., de Vries MR; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.; Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Giera M; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands., Rose-John S; Department of Biochemistry, Christian-Albrechts-Universität zu Kiel, Kiel, Germany., Zelcer N; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Gastroenterology Endocrinology Metabolism and Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, Netherlands., de Boer JF; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands., de Aguiar Vallim TQ; Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Febbraio MA; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Rensen PCN; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands., Schönke M; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.
Source: Science advances [Sci Adv] 2025 Oct 24; Vol. 11 (43), pp. eadx3794. Date of Electronic Publication: 2025 Oct 24.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice.
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  Data: <searchLink fieldCode="AU" term="%22In+Het+Panhuis+W%22">In Het Panhuis W</searchLink>; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.; Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Thiemann+E%22">Thiemann E</searchLink>; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Dijk+DMAH%22">van Dijk DMAH</searchLink>; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Been+B%22">Been B</searchLink>; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Jarrett+KE%22">Jarrett KE</searchLink>; Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Meurs+A%22">Meurs A</searchLink>; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Gastroenterology Endocrinology Metabolism and Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kooijman+S%22">Kooijman S</searchLink>; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Hovingh+MV%22">Hovingh MV</searchLink>; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Modder+M%22">Modder M</searchLink>; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Os+BW%22">van Os BW</searchLink>; Department of Medical Biochemistry, Amsterdam University Medical Centers, Amsterdam, Netherlands.; Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, Netherlands.; Amsterdam Immunity and Infection, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Sluiter+TJ%22">Sluiter TJ</searchLink>; 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Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Lalai+RA%22">Lalai RA</searchLink>; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Taveras+MO%22">Taveras MO</searchLink>; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Adams+TE%22">Adams TE</searchLink>; CSIRO Manufacturing, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Terry+LV%22">Terry LV</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Turpin-Nolan+SM%22">Turpin-Nolan SM</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22de+Vries+MR%22">de Vries MR</searchLink>; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.; Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Giera+M%22">Giera M</searchLink>; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Rose-John+S%22">Rose-John S</searchLink>; Department of Biochemistry, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Zelcer+N%22">Zelcer N</searchLink>; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Gastroenterology Endocrinology Metabolism and Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Boer+JF%22">de Boer JF</searchLink>; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Aguiar+Vallim+TQ%22">de Aguiar Vallim TQ</searchLink>; Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Febbraio+MA%22">Febbraio MA</searchLink>; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Rensen+PCN%22">Rensen PCN</searchLink>; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Schönke+M%22">Schönke M</searchLink>; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.
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