Murine vascular organoids are responsive and adaptable 3D systems with cellular heterogeneity and dynamic plasticity.

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Title: Murine vascular organoids are responsive and adaptable 3D systems with cellular heterogeneity and dynamic plasticity.
Authors: Guelfi S; Laboratory of Tumor Microenvironment and Therapeutic Resistance, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Gopalan KS; Laboratory of Tumor Microenvironment and Therapeutic Resistance, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Maene P; Laboratory of Tumor Microenvironment and Therapeutic Resistance, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Robbert DJ; Laboratory of Tumor Microenvironment and Therapeutic Resistance, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Pallarés-Moratalla C; Laboratory of Tumor Microenvironment and Therapeutic Resistance, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Vella G; Laboratory of Tumor Microenvironment and Therapeutic Resistance, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium., Nobis M; Department of Oncology, KU Leuven, Leuven, Belgium.; Intravital Imaging Expertise Center, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Manchester Cell-Matrix Centre, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, UK., Mourao L; Department of Oncology, KU Leuven, Leuven, Belgium.; Laboratory for Intravital Imaging and Dynamics of Tumor Progression, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium., Bourdely P; Department of Oncology, KU Leuven, Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium., van der Veer BK; Laboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), Leuven, Belgium., Koh KP; Department of Oncology, KU Leuven, Leuven, Belgium.; Laboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.; Department of Molecular and Cellular Biology, Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA., Mazzone M; Department of Oncology, KU Leuven, Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium., Scheele CLGJ; Department of Oncology, KU Leuven, Leuven, Belgium.; Laboratory for Intravital Imaging and Dynamics of Tumor Progression, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium., Bergers G; Laboratory of Tumor Microenvironment and Therapeutic Resistance, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.; Department of Oncology, KU Leuven, Leuven, Belgium.
Source: Science advances [Sci Adv] 2025 Oct 24; Vol. 11 (43), pp. eady4738. Date of Electronic Publication: 2025 Oct 24.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2375-2548
DOI:10.1126/sciadv.ady4738