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Acquisition of an immunosuppressive microenvironment after anti-CD19 CAR T-cell therapy is associated with T-cell dysfunction and resistance.

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Title: Acquisition of an immunosuppressive microenvironment after anti-CD19 CAR T-cell therapy is associated with T-cell dysfunction and resistance.
Authors: Ponzo M; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zürich, Switzerland., Drufuca L; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy., Buracchi C; Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Sindoni MM; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy., Nucera S; Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Bugarin C; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Bason R; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy., Rossetti G; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy., Bonnal R; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy., Meli C; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Rambaldi B; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Lussana F; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Ferrari S; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Moretti A; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy., Dastoli G; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Risca G; Bicocca Bioinformatics, Biostatistics and Bioimaging B4 Centre, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy., Pellegrino C; Department of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zürich, Switzerland., Manz MG; Department of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zürich, Switzerland., Galimberti S; Bicocca Bioinformatics, Biostatistics and Bioimaging B4 Centre, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.; Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Rambaldi A; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Gaipa G; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Biondi A; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy chiara.magnani@usz.ch abiondi.unimib@gmail.com., Pagani M; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy., Magnani CF; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy chiara.magnani@usz.ch abiondi.unimib@gmail.com.; Department of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Oct 23; Vol. 13 (10). Date of Electronic Publication: 2025 Oct 23.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Acquisition of an immunosuppressive microenvironment after anti-CD19 CAR T-cell therapy is associated with T-cell dysfunction and resistance.
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  Data: <searchLink fieldCode="AU" term="%22Ponzo+M%22">Ponzo M</searchLink>; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Drufuca+L%22">Drufuca L</searchLink>; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Buracchi+C%22">Buracchi C</searchLink>; Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Sindoni+MM%22">Sindoni MM</searchLink>; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Nucera+S%22">Nucera S</searchLink>; Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Bugarin+C%22">Bugarin C</searchLink>; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Bason+R%22">Bason R</searchLink>; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rossetti+G%22">Rossetti G</searchLink>; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bonnal+R%22">Bonnal R</searchLink>; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Meli+C%22">Meli C</searchLink>; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Rambaldi+B%22">Rambaldi B</searchLink>; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Lussana+F%22">Lussana F</searchLink>; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrari+S%22">Ferrari S</searchLink>; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Moretti+A%22">Moretti A</searchLink>; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Dastoli+G%22">Dastoli G</searchLink>; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Risca+G%22">Risca G</searchLink>; Bicocca Bioinformatics, Biostatistics and Bioimaging B4 Centre, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pellegrino+C%22">Pellegrino C</searchLink>; Department of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Manz+MG%22">Manz MG</searchLink>; Department of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Galimberti+S%22">Galimberti S</searchLink>; Bicocca Bioinformatics, Biostatistics and Bioimaging B4 Centre, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.; Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Rambaldi+A%22">Rambaldi A</searchLink>; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Gaipa+G%22">Gaipa G</searchLink>; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Biondi+A%22">Biondi A</searchLink>; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy chiara.magnani@usz.ch abiondi.unimib@gmail.com.<br /><searchLink fieldCode="AU" term="%22Pagani+M%22">Pagani M</searchLink>; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Magnani+CF%22">Magnani CF</searchLink>; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy chiara.magnani@usz.ch abiondi.unimib@gmail.com.; Department of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2025 Oct 23; Vol. 13 (10). <i>Date of Electronic Publication: </i>2025 Oct 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE
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