Acquisition of an immunosuppressive microenvironment after anti-CD19 CAR T-cell therapy is associated with T-cell dysfunction and resistance.
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| Title: | Acquisition of an immunosuppressive microenvironment after anti-CD19 CAR T-cell therapy is associated with T-cell dysfunction and resistance. |
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| Authors: | Ponzo M; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zürich, Switzerland., Drufuca L; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy., Buracchi C; Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Sindoni MM; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy., Nucera S; Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Bugarin C; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Bason R; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy., Rossetti G; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy., Bonnal R; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy., Meli C; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Rambaldi B; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Lussana F; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Ferrari S; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Moretti A; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy., Dastoli G; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Risca G; Bicocca Bioinformatics, Biostatistics and Bioimaging B4 Centre, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy., Pellegrino C; Department of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zürich, Switzerland., Manz MG; Department of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zürich, Switzerland., Galimberti S; Bicocca Bioinformatics, Biostatistics and Bioimaging B4 Centre, Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.; Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Rambaldi A; Department of Oncology-Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy., Gaipa G; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Biondi A; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy chiara.magnani@usz.ch abiondi.unimib@gmail.com., Pagani M; IFOM ETS, The AIRC Institute of Molecular Oncology, Milan, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy., Magnani CF; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy chiara.magnani@usz.ch abiondi.unimib@gmail.com.; Department of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Zürich, Switzerland. |
| Source: | Journal for immunotherapy of cancer [J Immunother Cancer] 2025 Oct 23; Vol. 13 (10). Date of Electronic Publication: 2025 Oct 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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