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SETDB1 is critically required for uveal melanoma growth and represents a promising therapeutic target.

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Title: SETDB1 is critically required for uveal melanoma growth and represents a promising therapeutic target.
Authors: Krossa I; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Pisibon C; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Cheli Y; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Bille K; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Dalmasso M; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Hamadat S; CNRS UMR9019 Genome Integrity and Cancers, Université Paris-Saclay, Gustave Roussy, Villejuif, France.; Inovarion, Paris, 75005, France., Husser C; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Irondelle M; University Côte d'Azur, Nice, France., Cherfils-Vicini J; University Côte d'Azur, Nice, France.; Centre National de la Recherche Scientifique (CNRS) UMR7284, Inserm U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice, 06107, France., Soysouvanh F; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Nahon-Esteve S; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.; Department of Ophthalmology, Centre Hospitalier Universitaire of Nice, Nice, France., Martel A; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.; Department of Ophthalmology, Centre Hospitalier Universitaire of Nice, Nice, France., Lassalle S; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.; Laboratory of Clinical and Experimental Pathology (LPCE), Biobank BB-0033-00025, Nice, France., Caujolle JP; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.; Department of Ophthalmology, Centre Hospitalier Universitaire of Nice, Nice, France., Maschi C; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.; Department of Ophthalmology, Centre Hospitalier Universitaire of Nice, Nice, France., Baillif S; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.; Department of Ophthalmology, Centre Hospitalier Universitaire of Nice, Nice, France., Hasson D; Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) Core, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Carcamo S; Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) Core, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Aplin AE; Department of Pharmacology, Physiology and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.; Sidney Kimmel Comprehensive Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Davidson I; IGBMC, CNRS UMR7104, INSERM U1258, Université de Strasbourg, Illkirch, France., Bernstein E; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA., Naim V; CNRS UMR9019 Genome Integrity and Cancers, Université Paris-Saclay, Gustave Roussy, Villejuif, France., Ballotti R; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France., Bertolotto C; University Côte d'Azur, Nice, France. Corine.Bertolotto@univ-cotedazur.fr.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France. Corine.Bertolotto@univ-cotedazur.fr., Strub T; University Côte d'Azur, Nice, France. thomas.strub@univ-cotedazur.fr.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France. thomas.strub@univ-cotedazur.fr.
Source: Cell death & disease [Cell Death Dis] 2025 Oct 24; Vol. 16 (1), pp. 754. Date of Electronic Publication: 2025 Oct 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: SETDB1 is critically required for uveal melanoma growth and represents a promising therapeutic target.
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  Data: <searchLink fieldCode="AU" term="%22Krossa+I%22">Krossa I</searchLink>; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Pisibon+C%22">Pisibon C</searchLink>; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Cheli+Y%22">Cheli Y</searchLink>; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Bille+K%22">Bille K</searchLink>; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Dalmasso+M%22">Dalmasso M</searchLink>; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Hamadat+S%22">Hamadat S</searchLink>; CNRS UMR9019 Genome Integrity and Cancers, Université Paris-Saclay, Gustave Roussy, Villejuif, France.; Inovarion, Paris, 75005, France.<br /><searchLink fieldCode="AU" term="%22Husser+C%22">Husser C</searchLink>; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Irondelle+M%22">Irondelle M</searchLink>; University Côte d'Azur, Nice, France.<br /><searchLink fieldCode="AU" term="%22Cherfils-Vicini+J%22">Cherfils-Vicini J</searchLink>; University Côte d'Azur, Nice, France.; Centre National de la Recherche Scientifique (CNRS) UMR7284, Inserm U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice, 06107, France.<br /><searchLink fieldCode="AU" term="%22Soysouvanh+F%22">Soysouvanh F</searchLink>; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Nahon-Esteve+S%22">Nahon-Esteve S</searchLink>; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.; Department of Ophthalmology, Centre Hospitalier Universitaire of Nice, Nice, France.<br /><searchLink fieldCode="AU" term="%22Martel+A%22">Martel A</searchLink>; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.; Department of Ophthalmology, Centre Hospitalier Universitaire of Nice, Nice, France.<br /><searchLink fieldCode="AU" term="%22Lassalle+S%22">Lassalle S</searchLink>; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.; Laboratory of Clinical and Experimental Pathology (LPCE), Biobank BB-0033-00025, Nice, France.<br /><searchLink fieldCode="AU" term="%22Caujolle+JP%22">Caujolle JP</searchLink>; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.; Department of Ophthalmology, Centre Hospitalier Universitaire of Nice, Nice, France.<br /><searchLink fieldCode="AU" term="%22Maschi+C%22">Maschi C</searchLink>; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.; Department of Ophthalmology, Centre Hospitalier Universitaire of Nice, Nice, France.<br /><searchLink fieldCode="AU" term="%22Baillif+S%22">Baillif S</searchLink>; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.; Department of Ophthalmology, Centre Hospitalier Universitaire of Nice, Nice, France.<br /><searchLink fieldCode="AU" term="%22Hasson+D%22">Hasson D</searchLink>; Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) Core, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.<br /><searchLink fieldCode="AU" term="%22Carcamo+S%22">Carcamo S</searchLink>; Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) Core, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.<br /><searchLink fieldCode="AU" term="%22Aplin+AE%22">Aplin AE</searchLink>; Department of Pharmacology, Physiology and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.; Sidney Kimmel Comprehensive Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA.<br /><searchLink fieldCode="AU" term="%22Davidson+I%22">Davidson I</searchLink>; IGBMC, CNRS UMR7104, INSERM U1258, Université de Strasbourg, Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Bernstein+E%22">Bernstein E</searchLink>; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.<br /><searchLink fieldCode="AU" term="%22Naim+V%22">Naim V</searchLink>; CNRS UMR9019 Genome Integrity and Cancers, Université Paris-Saclay, Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Ballotti+R%22">Ballotti R</searchLink>; University Côte d'Azur, Nice, France.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France.<br /><searchLink fieldCode="AU" term="%22Bertolotto+C%22">Bertolotto C</searchLink>; University Côte d'Azur, Nice, France. Corine.Bertolotto@univ-cotedazur.fr.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France. Corine.Bertolotto@univ-cotedazur.fr.<br /><searchLink fieldCode="AU" term="%22Strub+T%22">Strub T</searchLink>; University Côte d'Azur, Nice, France. thomas.strub@univ-cotedazur.fr.; Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2025 and Equipe labellisée ARC 2022, Centre Méditerranéen de Médecine Moléculaire, Nice, France. thomas.strub@univ-cotedazur.fr.
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