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Development of [18F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology.

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Title: Development of [18F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology.
Authors: Vokali E; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Chevalier E; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Dreyfus N; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Charmey D; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Melly T; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Kocher J; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Ratnam M; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Serra AM; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Jaquier T; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Delgado C; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Ravache M; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Scialò C; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Cappelli S; Molecular Pathology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy., Kroth H; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Capotosti F; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Luthi-Carter R; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Afroz T; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Derouazi M; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Constantinescu CC; Perceptive Inc., New Haven, CT, USA., Seelaar H; Department of Neurology, Erasmus University Medical Centre, Rotterdam, The Netherlands., Buratti E; Molecular Pathology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy., Nelson PT; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Polymenidou M; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland., Pfeifer A; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Kosco-Vilbois M; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland., Seredenina T; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland. tamara.seredenina@acimmune.com.
Source: Nature communications [Nat Commun] 2025 Oct 24; Vol. 16 (1), pp. 9358. Date of Electronic Publication: 2025 Oct 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Development of [<superscript>18</superscript>F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology.
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  Data: <searchLink fieldCode="AU" term="%22Vokali+E%22">Vokali E</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chevalier+E%22">Chevalier E</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dreyfus+N%22">Dreyfus N</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Charmey+D%22">Charmey D</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Melly+T%22">Melly T</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kocher+J%22">Kocher J</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ratnam+M%22">Ratnam M</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Serra+AM%22">Serra AM</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jaquier+T%22">Jaquier T</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Delgado+C%22">Delgado C</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ravache+M%22">Ravache M</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Scialò+C%22">Scialò C</searchLink>; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cappelli+S%22">Cappelli S</searchLink>; Molecular Pathology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Kroth+H%22">Kroth H</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Capotosti+F%22">Capotosti F</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Luthi-Carter+R%22">Luthi-Carter R</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Afroz+T%22">Afroz T</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Derouazi+M%22">Derouazi M</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Constantinescu+CC%22">Constantinescu CC</searchLink>; Perceptive Inc., New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Seelaar+H%22">Seelaar H</searchLink>; Department of Neurology, Erasmus University Medical Centre, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Buratti+E%22">Buratti E</searchLink>; Molecular Pathology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Nelson+PT%22">Nelson PT</searchLink>; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Polymenidou+M%22">Polymenidou M</searchLink>; Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pfeifer+A%22">Pfeifer A</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kosco-Vilbois+M%22">Kosco-Vilbois M</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Seredenina+T%22">Seredenina T</searchLink>; AC Immune SA, EPFL Innovation Park, Building B, Lausanne, Switzerland. tamara.seredenina@acimmune.com.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Oct 24; Vol. 16 (1), pp. 9358. <i>Date of Electronic Publication: </i>2025 Oct 24.
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