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Revisiting COX-2 inhibitors for Alzheimer's disease as multitargeted ligands: Development of 4-hydrazono-pyrazolidinediones with tuned COX selectivity profile and improved cellular potency.

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Title: Revisiting COX-2 inhibitors for Alzheimer's disease as multitargeted ligands: Development of 4-hydrazono-pyrazolidinediones with tuned COX selectivity profile and improved cellular potency.
Authors: Waheed R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt., Mostafa Z; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt., Emad M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt., Darwish SS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt; School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, 11578, Cairo, Egypt., Purgatorio R; Department of Pharmacy and Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, (Italy)., Miniero DV; Department of Medicine and Surgery, LUM University Giuseppe Degennaro, Torre Rossi, 70010, Casamassima, Italy; Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy., De Palma A; Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy., Cheng TP; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan., Wang TY; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, 807, Taiwan., Chen YC; Center for Drug Research and Development, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 333, Taiwan; Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 333324, Taiwan., El Kerdawy AM; School of Health and Care Sciences, College of Health and Science, University of Lincoln, Joseph Banks Laboratories, Green Lane, Lincoln, United Kingdom; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, P.O. Box 11562, Cairo, Egypt., Gabr M; Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, New York, NY, 10065, USA., Catto M; Department of Pharmacy and Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, (Italy)., Abadi AH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt., Hwang TL; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan; Center for Drug Research and Development, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 333, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, 333, Taiwan; School of Chinese Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, 243, Taiwan. Electronic address: htl@mail.cgust.edu.tw., Abdel-Halim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt. Electronic address: mohammad.abdel-halim@guc.edu.eg.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Jan 15; Vol. 302 (Pt 1), pp. 118261. Date of Electronic Publication: 2025 Oct 13.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Waheed+R%22">Waheed R</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt.<br /><searchLink fieldCode="AU" term="%22Mostafa+Z%22">Mostafa Z</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt.<br /><searchLink fieldCode="AU" term="%22Emad+M%22">Emad M</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt.<br /><searchLink fieldCode="AU" term="%22Darwish+SS%22">Darwish SS</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt; School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, 11578, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Purgatorio+R%22">Purgatorio R</searchLink>; Department of Pharmacy and Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, (Italy).<br /><searchLink fieldCode="AU" term="%22Miniero+DV%22">Miniero DV</searchLink>; Department of Medicine and Surgery, LUM University Giuseppe Degennaro, Torre Rossi, 70010, Casamassima, Italy; Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22De+Palma+A%22">De Palma A</searchLink>; Department of Biosciences, Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Cheng+TP%22">Cheng TP</searchLink>; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+TY%22">Wang TY</searchLink>; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, 807, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YC%22">Chen YC</searchLink>; Center for Drug Research and Development, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 333, Taiwan; Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 333324, Taiwan.<br /><searchLink fieldCode="AU" term="%22El+Kerdawy+AM%22">El Kerdawy AM</searchLink>; School of Health and Care Sciences, College of Health and Science, University of Lincoln, Joseph Banks Laboratories, Green Lane, Lincoln, United Kingdom; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, P.O. Box 11562, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Gabr+M%22">Gabr M</searchLink>; Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Catto+M%22">Catto M</searchLink>; Department of Pharmacy and Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari, (Italy).<br /><searchLink fieldCode="AU" term="%22Abadi+AH%22">Abadi AH</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt.<br /><searchLink fieldCode="AU" term="%22Hwang+TL%22">Hwang TL</searchLink>; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan; Center for Drug Research and Development, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 333, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, 333, Taiwan; School of Chinese Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, 243, Taiwan. Electronic address: htl@mail.cgust.edu.tw.<br /><searchLink fieldCode="AU" term="%22Abdel-Halim+M%22">Abdel-Halim M</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, 11835, Egypt. Electronic address: mohammad.abdel-halim@guc.edu.eg.
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