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SARS-CoV-2-Specific Immune Responses to Vaccination in Children and Adolescents with Suppressed Immune Systems: A Prospective, Observational Study.

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Title: SARS-CoV-2-Specific Immune Responses to Vaccination in Children and Adolescents with Suppressed Immune Systems: A Prospective, Observational Study.
Authors: Brugha R; Cardiothoracic Transplantation, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom; National Institute for Health Research (NIHR) GOSH Biomedical Research Centre, London, United Kingdom. Electronic address: rossa.brugha@gosh.nhs.uk., Kirkham A; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom., Bate J; Department of Pediatric Oncology, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom., Burke GAA; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom; Department of Pediatric Oncology and Hematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Hughes A; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom., Magwaro S; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom., Pope AM; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom., Beesley R; Patient Representative for the OCTAVE Study, Juvenile Arthritis Research, Tonbridge, United Kingdom., Lax S; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom., Kelly E; Department of Pediatrics, Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Greenland M; Department of Pediatrics, Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Minassian AM; Department of Pediatrics, Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; Department of Biochemistry, University of Oxford, Oxford, United Kingdom., Liu X; Department of Pediatrics, Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Billingham L; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom., McInnes I; College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom., Goodyear CS; College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom., Kearns P; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom., Wedderburn LR; National Institute for Health Research (NIHR) GOSH Biomedical Research Centre, London, United Kingdom; Pediatric Rheumatology, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom; Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Corporate Authors: OCTAVE-Minor Collaborative Group
Source: The Journal of pediatrics [J Pediatr] 2026 Feb; Vol. 289, pp. 114873. Date of Electronic Publication: 2025 Oct 24.
Publication Type: Journal Article; Observational Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 0375410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6833 (Electronic) Linking ISSN: 00223476 NLM ISO Abbreviation: J Pediatr Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Brugha+R%22">Brugha R</searchLink>; Cardiothoracic Transplantation, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom; National Institute for Health Research (NIHR) GOSH Biomedical Research Centre, London, United Kingdom. Electronic address: rossa.brugha@gosh.nhs.uk.<br /><searchLink fieldCode="AU" term="%22Kirkham+A%22">Kirkham A</searchLink>; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bate+J%22">Bate J</searchLink>; Department of Pediatric Oncology, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Burke+GAA%22">Burke GAA</searchLink>; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom; Department of Pediatric Oncology and Hematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hughes+A%22">Hughes A</searchLink>; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Magwaro+S%22">Magwaro S</searchLink>; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pope+AM%22">Pope AM</searchLink>; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Beesley+R%22">Beesley R</searchLink>; Patient Representative for the OCTAVE Study, Juvenile Arthritis Research, Tonbridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lax+S%22">Lax S</searchLink>; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kelly+E%22">Kelly E</searchLink>; Department of Pediatrics, Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Greenland+M%22">Greenland M</searchLink>; Department of Pediatrics, Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Minassian+AM%22">Minassian AM</searchLink>; Department of Pediatrics, Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; Department of Biochemistry, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Pediatrics, Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Billingham+L%22">Billingham L</searchLink>; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22McInnes+I%22">McInnes I</searchLink>; College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Goodyear+CS%22">Goodyear CS</searchLink>; College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kearns+P%22">Kearns P</searchLink>; Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham Edgbaston, Birmingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wedderburn+LR%22">Wedderburn LR</searchLink>; National Institute for Health Research (NIHR) GOSH Biomedical Research Centre, London, United Kingdom; Pediatric Rheumatology, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom; Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
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