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Mass spectrometry-based major phytochemicals and dose dependent cytotoxic and nephrotoxic effects of Commiphora leptophloeos stem bark extract in preclinical in vitro and in vivo models.

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Title: Mass spectrometry-based major phytochemicals and dose dependent cytotoxic and nephrotoxic effects of Commiphora leptophloeos stem bark extract in preclinical in vitro and in vivo models.
Authors: Dantas-Medeiros R; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: renato.medeiros.071@ufrn.edu.br., Medeiros-Dantas M; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: mikaeli.medeiros@gmail.com., de Aragão Tavares E; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: emanuella_ta@hotmail.com., de Araújo ERD; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: edilanearaujo@hotmail.com., Bonfim AVL; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: ariana.bonfim.704@ufrn.edu.br., de Araújo LMN; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: lucas.araujo.095@ufrn.edu.br., Torres-Rêgo M; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: manoela.torres.072@ufrn.edu.br., Ururahy MAG; Department of Clinical and Toxicological Analysis, Health Sciences Center, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: marcela.ururahy@ufrn.br., Galinari É; Department of Biological Sciences, Federal University of Ouro Preto, Campus Morro do Cruzeiro, S/N, Morro do Cruzeiro, 35402-163, Ouro Preto-PE, Brazil. Electronic address: eder.galinari@ufop.edu.br., da Silva VC; Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, 59072-970, Natal, Brazil. Electronic address: valeria.costa.098@ufrn.edu.br., de Oliveira Moura Araújo E; Researcher at the Specialized Academic Unit in Agricultural Sciences at the Federal University of Rio Grande do Norte, 59072-970, Natal, Brazil. Electronic address: manu_moura9@yahoo.com.br., Zanatta AC; Department of Pharmaceutical Sciences, Faculty of Pharmacy, São Paulo University, 14040-900, Ribeirão Preto, Brazil. Electronic address: anaczanatta@gmail.com., Zucolotto SM; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: silvana.zucolotto@ufrn.br., Guerra GCB; Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, 59072-970, Natal, Brazil. Electronic address: gerlane.guerra@ufrn.br.
Source: Journal of ethnopharmacology [J Ethnopharmacol] 2026 Feb 10; Vol. 356, pp. 120779. Date of Electronic Publication: 2025 Oct 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE
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  Data: Mass spectrometry-based major phytochemicals and dose dependent cytotoxic and nephrotoxic effects of Commiphora leptophloeos stem bark extract in preclinical in vitro and in vivo models.
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  Data: <searchLink fieldCode="AU" term="%22Dantas-Medeiros+R%22">Dantas-Medeiros R</searchLink>; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: renato.medeiros.071@ufrn.edu.br.<br /><searchLink fieldCode="AU" term="%22Medeiros-Dantas+M%22">Medeiros-Dantas M</searchLink>; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: mikaeli.medeiros@gmail.com.<br /><searchLink fieldCode="AU" term="%22de+Aragão+Tavares+E%22">de Aragão Tavares E</searchLink>; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: emanuella_ta@hotmail.com.<br /><searchLink fieldCode="AU" term="%22de+Araújo+ERD%22">de Araújo ERD</searchLink>; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: edilanearaujo@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Bonfim+AVL%22">Bonfim AVL</searchLink>; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: ariana.bonfim.704@ufrn.edu.br.<br /><searchLink fieldCode="AU" term="%22de+Araújo+LMN%22">de Araújo LMN</searchLink>; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: lucas.araujo.095@ufrn.edu.br.<br /><searchLink fieldCode="AU" term="%22Torres-Rêgo+M%22">Torres-Rêgo M</searchLink>; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: manoela.torres.072@ufrn.edu.br.<br /><searchLink fieldCode="AU" term="%22Ururahy+MAG%22">Ururahy MAG</searchLink>; Department of Clinical and Toxicological Analysis, Health Sciences Center, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: marcela.ururahy@ufrn.br.<br /><searchLink fieldCode="AU" term="%22Galinari+É%22">Galinari É</searchLink>; Department of Biological Sciences, Federal University of Ouro Preto, Campus Morro do Cruzeiro, S/N, Morro do Cruzeiro, 35402-163, Ouro Preto-PE, Brazil. Electronic address: eder.galinari@ufop.edu.br.<br /><searchLink fieldCode="AU" term="%22da+Silva+VC%22">da Silva VC</searchLink>; Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, 59072-970, Natal, Brazil. Electronic address: valeria.costa.098@ufrn.edu.br.<br /><searchLink fieldCode="AU" term="%22de+Oliveira+Moura+Araújo+E%22">de Oliveira Moura Araújo E</searchLink>; Researcher at the Specialized Academic Unit in Agricultural Sciences at the Federal University of Rio Grande do Norte, 59072-970, Natal, Brazil. Electronic address: manu_moura9@yahoo.com.br.<br /><searchLink fieldCode="AU" term="%22Zanatta+AC%22">Zanatta AC</searchLink>; Department of Pharmaceutical Sciences, Faculty of Pharmacy, São Paulo University, 14040-900, Ribeirão Preto, Brazil. Electronic address: anaczanatta@gmail.com.<br /><searchLink fieldCode="AU" term="%22Zucolotto+SM%22">Zucolotto SM</searchLink>; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Rio Grande do Norte, Avenue General Gustavo Cordeiro de Farias, S/N, Petrópolis, 59012-570, Natal, Brazil. Electronic address: silvana.zucolotto@ufrn.br.<br /><searchLink fieldCode="AU" term="%22Guerra+GCB%22">Guerra GCB</searchLink>; Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, 59072-970, Natal, Brazil. Electronic address: gerlane.guerra@ufrn.br.
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  Data: <searchLink fieldCode="JN" term="%227903310%22">Journal of ethnopharmacology</searchLink> [J Ethnopharmacol] 2026 Feb 10; Vol. 356, pp. 120779. <i>Date of Electronic Publication: </i>2025 Oct 24.
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