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Phase 2 Study of Amivantamab Plus Lazertinib in Previously Treated Patients With EGFR-Mutant Lung Cancers With Brain and Leptomeningeal Metastases.

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Title: Phase 2 Study of Amivantamab Plus Lazertinib in Previously Treated Patients With EGFR-Mutant Lung Cancers With Brain and Leptomeningeal Metastases.
Authors: Chen MF; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York., Lee JJ; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Choudhury NJ; Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, Illinois., Hui AB; Department of Radiation Oncology, Stanford University, Stanford, California., Jeng MY; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Zheng J; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Aly RG; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York., Sielski N; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York., Ahn L; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Pupo A; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Nesselbush MC; Department of Radiation Oncology, Stanford University, Stanford, California; Department of Biology, Stanford University, Stanford, California., Jabara I; Department of Radiation Oncology, Stanford University, Stanford, California; Department of Biology, Stanford University, Stanford, California., Wilcox JA; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York., Santomasso BD; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York., Lin AL; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York., Schaff L; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York., Chaft JE; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York., Riely GJ; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York., Kris MG; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York., Arfe A; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Yang SR; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York., Young RJ; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, New York., Diehn M; Department of Radiation Oncology, Stanford University, Stanford, California; Department of Biology, Stanford University, Stanford, California; Stanford Cancer Institute, Stanford University, Stanford, California., Boire A; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York; Human Oncology & Pathogenesis, Memorial Sloan Kettering Cancer Center, New York, New York., Yu HA; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York. Electronic address: yuh@mskcc.org.
Source: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2026 Mar; Vol. 21 (3), pp. 103505. Date of Electronic Publication: 2025 Oct 23.
Publication Type: Journal Article; Clinical Trial, Phase II; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101274235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-1380 (Electronic) Linking ISSN: 15560864 NLM ISO Abbreviation: J Thorac Oncol Subsets: MEDLINE
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  Data: Phase 2 Study of Amivantamab Plus Lazertinib in Previously Treated Patients With EGFR-Mutant Lung Cancers With Brain and Leptomeningeal Metastases.
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  Data: <searchLink fieldCode="AU" term="%22Chen+MF%22">Chen MF</searchLink>; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York.<br /><searchLink fieldCode="AU" term="%22Lee+JJ%22">Lee JJ</searchLink>; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Choudhury+NJ%22">Choudhury NJ</searchLink>; Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Hui+AB%22">Hui AB</searchLink>; Department of Radiation Oncology, Stanford University, Stanford, California.<br /><searchLink fieldCode="AU" term="%22Jeng+MY%22">Jeng MY</searchLink>; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Zheng+J%22">Zheng J</searchLink>; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Aly+RG%22">Aly RG</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Sielski+N%22">Sielski N</searchLink>; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Ahn+L%22">Ahn L</searchLink>; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Pupo+A%22">Pupo A</searchLink>; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Nesselbush+MC%22">Nesselbush MC</searchLink>; Department of Radiation Oncology, Stanford University, Stanford, California; Department of Biology, Stanford University, Stanford, California.<br /><searchLink fieldCode="AU" term="%22Jabara+I%22">Jabara I</searchLink>; Department of Radiation Oncology, Stanford University, Stanford, California; Department of Biology, Stanford University, Stanford, California.<br /><searchLink fieldCode="AU" term="%22Wilcox+JA%22">Wilcox JA</searchLink>; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Santomasso+BD%22">Santomasso BD</searchLink>; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Lin+AL%22">Lin AL</searchLink>; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Schaff+L%22">Schaff L</searchLink>; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Chaft+JE%22">Chaft JE</searchLink>; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York.<br /><searchLink fieldCode="AU" term="%22Riely+GJ%22">Riely GJ</searchLink>; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York.<br /><searchLink fieldCode="AU" term="%22Kris+MG%22">Kris MG</searchLink>; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York.<br /><searchLink fieldCode="AU" term="%22Arfe+A%22">Arfe A</searchLink>; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Yang+SR%22">Yang SR</searchLink>; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Young+RJ%22">Young RJ</searchLink>; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, New York.<br /><searchLink fieldCode="AU" term="%22Diehn+M%22">Diehn M</searchLink>; Department of Radiation Oncology, Stanford University, Stanford, California; Department of Biology, Stanford University, Stanford, California; Stanford Cancer Institute, Stanford University, Stanford, California.<br /><searchLink fieldCode="AU" term="%22Boire+A%22">Boire A</searchLink>; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York; Human Oncology & Pathogenesis, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Yu+HA%22">Yu HA</searchLink>; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Weill Cornell Medical College, New York, New York. Electronic address: yuh@mskcc.org.
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  Data: <searchLink fieldCode="JN" term="%22101274235%22">Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer</searchLink> [J Thorac Oncol] 2026 Mar; Vol. 21 (3), pp. 103505. <i>Date of Electronic Publication: </i>2025 Oct 23.
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  Data: Journal Article; Clinical Trial, Phase II; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101274235 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1556-1380 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215560864%22">15560864 </searchLink><i>NLM ISO Abbreviation: </i>J Thorac Oncol <i>Subsets: </i>MEDLINE
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      – TitleFull: Phase 2 Study of Amivantamab Plus Lazertinib in Previously Treated Patients With EGFR-Mutant Lung Cancers With Brain and Leptomeningeal Metastases.
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