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Thrombolysis With Tenecteplase for Minor Disabling Stroke: Secondary Analysis of the TEMPO-2 Randomized Clinical Trial.

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Title: Thrombolysis With Tenecteplase for Minor Disabling Stroke: Secondary Analysis of the TEMPO-2 Randomized Clinical Trial.
Authors: Zhang Y; Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.; Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada., Buck BH; Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.; Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada., Barber PA; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Chatterjee K; Countess of Chester Hospital NHS Foundation Trust, Chester, United Kingdom., Clarke B; St George's University Hospitals, London, United Kingdom., Choi PMC; Department of Neuroscience, Box Hill Hospital, Eastern Health, Melbourne, Victoria, Australia.; Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia., Hunter G; University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Ganesh A; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; The O'Brien Institute for Public Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Mishra SM; Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada., Williams D; Royal College of Surgeons Ireland (RCSI) University of Medicine and Health Sciences and Beaumont Hospital, Dublin, Ireland., Campbell BCV; Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia., Dowlatshahi D; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Hospital Research Institute, Ottawa Hospital, Ottawa, Ontario, Canada., Butcher KS; School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia., Krishnan K; Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom., Wiggam MI; Royal Victoria Hospital, Belfast, United Kingdom., Kleinig TJ; Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia., Muir KW; School of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom., Zerna C; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Städtisches Klinikum Dresden, Dresden, Germany., Field TS; Vancouver Stroke Program, Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada., Goyal M; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Yu AYX; Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada., Roffe C; Stroke Research, Keele University, Stoke-on-Trent, United Kingdom., Demchuck AM; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Parsons MW; Department of Neurology, Liverpool Hospital, University of New South Wales South Western Sydney Clinical School, Liverpool, New South Wales, Australia.; Ingham Institute of Applied Medical Research, Liverpool, New South Wales, Australia., Bazan R; Botucatu Medical School, São Paulo State University, São Paulo, Brazil., Ankolekar S; Department of Neurology, King's College Hospital, London, United Kingdom., Kennedy J; Acute Multidisciplinary Imaging and Interventional Centre, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Menon BK; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Mandzia JL; Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada., Pille A; Neurology Department, Hospital Moinhos de Vento, Porto Alegre, Brazil., Kelly PJ; Mater University Hospital, School of Medicine, University College Dublin, Dublin, Ireland., Marko M; Department of Neurology, Medical University of Vienna, Vienna, Austria., Singh N; Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada., Vatanpour S; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Lima FO; Stroke Unit, Hospital Geral De Fortaleza, Fortaleza-ce, Brazil., Catanese L; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada., Horn M; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Ghia D; Fiona Stanley Hospital, Murdoch, Western Australia, Australia.; University of Western Australia, Perth, Western Australia, Australia., Ferrari J; Department of Neurology, St John's of God Hospital Vienna, Vienna, Austria., Greisenegger S; Department of Neurology, Medical University of Vienna, Vienna, Austria., Hill MD; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Coutts SB; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Corporate Authors: TEMPO-2 Investigators
Source: JAMA neurology [JAMA Neurol] 2025 Dec 01; Vol. 82 (12), pp. 1243-1250.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE
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  Data: Thrombolysis With Tenecteplase for Minor Disabling Stroke: Secondary Analysis of the TEMPO-2 Randomized Clinical Trial.
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