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Characterization of endothelin-converting enzyme 1 as a key enzyme in the multienzyme Aβ degradation pathway.

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Title: Characterization of endothelin-converting enzyme 1 as a key enzyme in the multienzyme Aβ degradation pathway.
Authors: Ulku I; Integrated Program in Neuroscience, McGill University, Montreal, QC H3G 0B1, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada., Ansari FE; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada., Hancock MA; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada., Zhou H; Integrated Program in Neuroscience, McGill University, Montreal, QC H3G 0B1, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada., Cagnone G; Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, QC H3T 1C5, Canada.; Department of Ophthalmology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, QC H3T 1C5, Canada.; Department of Pharmacology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, QC H3T 1C5, Canada., Joyal JS; Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, QC H3T 1C5, Canada.; Department of Ophthalmology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, QC H3T 1C5, Canada.; Department of Pharmacology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, QC H3T 1C5, Canada., Fisher TAJ; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada., Kennedy TE; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada., Liebsch F; Integrated Program in Neuroscience, McGill University, Montreal, QC H3G 0B1, Canada.; Department of Chemistry, Institute of Biochemistry, University of Cologne, Cologne 50674, Germany., Multhaup G; Integrated Program in Neuroscience, McGill University, Montreal, QC H3G 0B1, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Nov 04; Vol. 122 (44), pp. e2507450122. Date of Electronic Publication: 2025 Oct 27.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Characterization of endothelin-converting enzyme 1 as a key enzyme in the multienzyme Aβ degradation pathway.
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  Data: <searchLink fieldCode="AU" term="%22Ulku+I%22">Ulku I</searchLink>; Integrated Program in Neuroscience, McGill University, Montreal, QC H3G 0B1, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada.<br /><searchLink fieldCode="AU" term="%22Ansari+FE%22">Ansari FE</searchLink>; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada.<br /><searchLink fieldCode="AU" term="%22Hancock+MA%22">Hancock MA</searchLink>; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada.<br /><searchLink fieldCode="AU" term="%22Zhou+H%22">Zhou H</searchLink>; Integrated Program in Neuroscience, McGill University, Montreal, QC H3G 0B1, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada.<br /><searchLink fieldCode="AU" term="%22Cagnone+G%22">Cagnone G</searchLink>; Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, QC H3T 1C5, Canada.; Department of Ophthalmology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, QC H3T 1C5, Canada.; Department of Pharmacology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, QC H3T 1C5, Canada.<br /><searchLink fieldCode="AU" term="%22Joyal+JS%22">Joyal JS</searchLink>; Department of Pediatrics, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, QC H3T 1C5, Canada.; Department of Ophthalmology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, QC H3T 1C5, Canada.; Department of Pharmacology, Centre Hospitalier Universitaire Sainte Justine Research Center, Montreal, QC H3T 1C5, Canada.<br /><searchLink fieldCode="AU" term="%22Fisher+TAJ%22">Fisher TAJ</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Kennedy+TE%22">Kennedy TE</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Liebsch+F%22">Liebsch F</searchLink>; Integrated Program in Neuroscience, McGill University, Montreal, QC H3G 0B1, Canada.; Department of Chemistry, Institute of Biochemistry, University of Cologne, Cologne 50674, Germany.<br /><searchLink fieldCode="AU" term="%22Multhaup+G%22">Multhaup G</searchLink>; Integrated Program in Neuroscience, McGill University, Montreal, QC H3G 0B1, Canada.; Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Nov 04; Vol. 122 (44), pp. e2507450122. <i>Date of Electronic Publication: </i>2025 Oct 27.
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              Text: 2025 Nov 04
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