Diagnostic Implications and Correlates of Plasma Adenosine Deaminase 2 Activity and ADA2 Variants.

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Title: Diagnostic Implications and Correlates of Plasma Adenosine Deaminase 2 Activity and ADA2 Variants.
Authors: Yue J; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangzhou, China., LeSon CE; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Rimland CA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Brodeur K; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; Medical Scientist Training Program, UMass Chan Medical School, Worcester, Massachusetts., Weng R; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Hsu EE; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Lam MT; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Meyer M; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Okada S; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan., Hsu ALD; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Alhezam MA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Perron MM; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Halyabar O; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Dedeoglu F; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Nigrovic PA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Shimamura A; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts., Rowe RG; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, Massachusetts., Cooper MA; Division of Rheumatology and Immunology, Department of Pediatrics, Washington University in St. Louis, St. Louis, Missouri., Vogel TP; Division of Rheumatology, Department of Pediatrics, Baylor College of Medicine and Center for Human Immunobiology, Texas Children's Hospital, Houston., Gillispie-Taylor M; Division of Rheumatology, Department of Pediatrics, Huffington Department of Education, Innovation, and Technology, Baylor College of Medicine, Texas Children's Hospital, Houston., Peterson R; Pediatric Rheumatology, Dell Children's Medical Group, Dell Medical School, University of Texas at Austin., Lin C; Section of Pediatric Rheumatology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora., Nowicki KD; Section of Pediatric Rheumatology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora., Dollerschell K; Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora., Nakano TA; Center for Cancer and Blood Disorders, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora., Labrosse R; Section of Allergy and Clinical Immunology, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada., Cochino AV; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.; Alessandrescu Rusescu National Institute of Mother and Child Health, Bucharest, Romania., Ioan A; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.; Alessandrescu Rusescu National Institute of Mother and Child Health, Bucharest, Romania., Mendonca LO; Discipline of Clinical Immunology and Allergy, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil.; Laboratory for Medical Investigation (LIM-19), Instituto do Coração, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil., Barros SF; Discipline of Clinical Immunology and Allergy, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil.; Laboratory for Medical Investigation (LIM-19), Instituto do Coração, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil., Kalil J; Discipline of Clinical Immunology and Allergy, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil.; Laboratory for Medical Investigation (LIM-19), Instituto do Coração, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil., Perez-Rojas J; Division of Clinical Immunology and Allergy, Department of Internal Medicine, Guillermo Almenara Irigoyen National Hospital, EsSalud, Lima, Peru., Diaz-Kuan A; Genetica Molecular, Universidad Peruana Cayetano Heredia, Lima, Peru., Sobel ES; Department of Medicine, University of Florida College of Medicine, Gainesville., Moussa T; Section of Pediatric Rheumatology, University of Florida College of Medicine - Jacksonville., Lee SSM; Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Novena, Singapore., Koh LW; Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Novena, Singapore., Khan A; Pediatric Rheumatology, SRCC Children's Hospital, Mumbai, India., Sutnga S; Pediatric Rheumatology, SRCC Children's Hospital, Mumbai, India., Khubchandani R; Pediatric Rheumatology, SRCC Children's Hospital, Mumbai, India., Shoman W; Pediatric Immunology and Rheumatology Unit, Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt., El Chazli Y; Pediatric Hematology Unit, Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Pinto B; Department of Clinical Immunology and Rheumatology, St. John's Medical College, St. John's National Academy of Health Sciences, Bengaluru, India., Kavadichanda C; Clinical Immunology and Rheumatology, RheumaCARE, Mysuru, India., Abraham RS; Diagnostic Immunology Laboratory, Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio., Sun X; Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine and Liangzhu Laboratory, Zhejiang University, Hangzhou, China., Zhou Q; Department of Rheumatology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine and Liangzhu Laboratory, Zhejiang University, Hangzhou, China., Naidu G; Clinical Immunology and Rheumatology Division, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Sharma A; Clinical Immunology and Rheumatology Division, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Esperanzate C; Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland., Kastner DL; Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland., Aksentijevich I; Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland., Kelly SJ; Department of Medicine, Duke University School of Medicine, Durham, North Carolina., Hershfield M; Department of Medicine, Duke University School of Medicine, Durham, North Carolina.; Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina., Tarrant TK; Department of Medicine, Duke University School of Medicine, Durham, North Carolina.; Department of Pathology, Duke University School of Medicine, Durham, North Carolina.; Durham Veteran's Health Administration Health Care System, Durham, North Carolina., Lee PY; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Source: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2026 Mar; Vol. 78 (3), pp. 734-742. Date of Electronic Publication: 2025 Dec 25.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101623795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2326-5205 (Electronic) Linking ISSN: 23265191 NLM ISO Abbreviation: Arthritis Rheumatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Diagnostic Implications and Correlates of Plasma Adenosine Deaminase 2 Activity and ADA2 Variants.
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Discipline of Clinical Immunology and Allergy, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil.; Laboratory for Medical Investigation (LIM-19), Instituto do Coração, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Kalil+J%22">Kalil J</searchLink>; Discipline of Clinical Immunology and Allergy, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil.; Laboratory for Medical Investigation (LIM-19), Instituto do Coração, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Perez-Rojas+J%22">Perez-Rojas J</searchLink>; Division of Clinical Immunology and Allergy, Department of Internal Medicine, Guillermo Almenara Irigoyen National Hospital, EsSalud, Lima, Peru.<br /><searchLink fieldCode="AU" term="%22Diaz-Kuan+A%22">Diaz-Kuan A</searchLink>; Genetica Molecular, Universidad Peruana Cayetano Heredia, Lima, Peru.<br /><searchLink fieldCode="AU" term="%22Sobel+ES%22">Sobel ES</searchLink>; 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            NameFull: Naidu G
      – PersonEntity:
          Name:
            NameFull: Sharma A
      – PersonEntity:
          Name:
            NameFull: Esperanzate C
      – PersonEntity:
          Name:
            NameFull: Kastner DL
      – PersonEntity:
          Name:
            NameFull: Aksentijevich I
      – PersonEntity:
          Name:
            NameFull: Kelly SJ
      – PersonEntity:
          Name:
            NameFull: Hershfield M
      – PersonEntity:
          Name:
            NameFull: Tarrant TK
      – PersonEntity:
          Name:
            NameFull: Lee PY
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: 2026 Mar
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2326-5205
          Numbering:
            – Type: volume
              Value: 78
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Arthritis & rheumatology (Hoboken, N.J.)
              Type: main
ResultId 1