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Intestine-derived sorbitol drives steatotic liver disease in the absence of gut bacteria.

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Title: Intestine-derived sorbitol drives steatotic liver disease in the absence of gut bacteria.
Authors: Jackstadt MM; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA., Fowle-Grider R; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA., Song MG; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA., Ward MH; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA., Barr M; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA., Cho K; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA., Palacios HH; Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO 63110, USA., Klein S; Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO 63110, USA., Shriver LP; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA., Patti GJ; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA.
Source: Science signaling [Sci Signal] 2025 Oct 28; Vol. 18 (910), pp. eadt3549. Date of Electronic Publication: 2025 Oct 28.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Jackstadt+MM%22">Jackstadt MM</searchLink>; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.<br /><searchLink fieldCode="AU" term="%22Fowle-Grider+R%22">Fowle-Grider R</searchLink>; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.<br /><searchLink fieldCode="AU" term="%22Song+MG%22">Song MG</searchLink>; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.<br /><searchLink fieldCode="AU" term="%22Ward+MH%22">Ward MH</searchLink>; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.<br /><searchLink fieldCode="AU" term="%22Barr+M%22">Barr M</searchLink>; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.<br /><searchLink fieldCode="AU" term="%22Cho+K%22">Cho K</searchLink>; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.<br /><searchLink fieldCode="AU" term="%22Palacios+HH%22">Palacios HH</searchLink>; Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Klein+S%22">Klein S</searchLink>; Center for Human Nutrition, Washington University in St. Louis, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Shriver+LP%22">Shriver LP</searchLink>; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.<br /><searchLink fieldCode="AU" term="%22Patti+GJ%22">Patti GJ</searchLink>; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.; Center for Mass Spectrometry and Metabolic Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63110, USA.
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  Data: <searchLink fieldCode="JN" term="%22101465400%22">Science signaling</searchLink> [Sci Signal] 2025 Oct 28; Vol. 18 (910), pp. eadt3549. <i>Date of Electronic Publication: </i>2025 Oct 28.
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