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BCLC strategy for prognosis prediction and treatment recommendations: The 2026 update.

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Title: BCLC strategy for prognosis prediction and treatment recommendations: The 2026 update.
Authors: Reig M; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Liver Oncology Unit, Liver Unit, ICMDM, Hospital Clínic Barcelona, Barcelona, Spain; University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain. Electronic address: mreig1@clinic.cat., Sanduzzi-Zamparelli M; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Liver Oncology Unit, Liver Unit, ICMDM, Hospital Clínic Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain., Forner A; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Liver Oncology Unit, Liver Unit, ICMDM, Hospital Clínic Barcelona, Barcelona, Spain; University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain., Rimola J; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Radiology Department, Liver Oncology Unit, CDI, Hospital Clínic Barcelona, Barcelona, Spain., Ferrer-Fàbrega J; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Surgery Department, Liver Oncology Unit, ICMDM, Hospital Clínic Barcelona, Barcelona, Spain., Burrel M; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Radiology Department, Liver Oncology Unit, CDI, Hospital Clínic Barcelona, Barcelona, Spain., Garcia-Criado Á; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Radiology Department, Liver Oncology Unit, CDI, Hospital Clínic Barcelona, Barcelona, Spain., Díaz A; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Pathology Department, CDB, Liver Oncology Unit, Hospital Clínic Barcelona, Barcelona, Spain., Llarch N; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Liver Oncology Unit, ICMDM, Hospital Clínic, Barcelona, Spain., Iserte G; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Liver Oncology Unit, ICMDM, Hospital Clínic, Barcelona, Spain., Mollà M; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Department of Radiation Oncology, ICAMS, Hospital Clínic Barcelona, Barcelona, Spain., Kelley RK; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA., Galle PR; Department of Internal Medicine, Mainz University Medical Center, Mainz, Germany., Mazzaferro V; Department of Oncology, University of Milan and HPB Surgery and Liver Transplantation, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Salem R; Department of Radiology, Section of Interventional Radiology, Northwestern University, Chicago, IL, USA., Sangro B; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Liver Unit, Clínica Universidad de Navarra, Pamplona, Spain., Singal AG; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Vogel A; Toronto General Hospital, Princess Margaret Centre, University of Toronto, Toronto, ON, Canada; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany., Yanagihara TK; University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA; Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA., Ayuso C; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Radiology Department, Liver Oncology Unit, CDI, Hospital Clínic Barcelona, Barcelona, Spain., Torres F; Biostatistics Unit, Medical School, Universitat Autònoma de Barcelona, Barcelona, Spain., Bruix J; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
Source: Journal of hepatology [J Hepatol] 2026 Mar; Vol. 84 (3), pp. 631-654. Date of Electronic Publication: 2025 Oct 27.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: BCLC strategy for prognosis prediction and treatment recommendations: The 2026 update.
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  Data: <searchLink fieldCode="AU" term="%22Reig+M%22">Reig M</searchLink>; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Liver Oncology Unit, Liver Unit, ICMDM, Hospital Clínic Barcelona, Barcelona, Spain; University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain. Electronic address: mreig1@clinic.cat.<br /><searchLink fieldCode="AU" term="%22Sanduzzi-Zamparelli+M%22">Sanduzzi-Zamparelli M</searchLink>; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Liver Oncology Unit, Liver Unit, ICMDM, Hospital Clínic Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Forner+A%22">Forner A</searchLink>; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Liver Oncology Unit, Liver Unit, ICMDM, Hospital Clínic Barcelona, Barcelona, Spain; University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rimola+J%22">Rimola J</searchLink>; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Radiology Department, Liver Oncology Unit, CDI, Hospital Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ferrer-Fàbrega+J%22">Ferrer-Fàbrega J</searchLink>; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Surgery Department, Liver Oncology Unit, ICMDM, Hospital Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Burrel+M%22">Burrel M</searchLink>; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Radiology Department, Liver Oncology Unit, CDI, Hospital Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Garcia-Criado+Á%22">Garcia-Criado Á</searchLink>; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Radiology Department, Liver Oncology Unit, CDI, Hospital Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Díaz+A%22">Díaz A</searchLink>; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Pathology Department, CDB, Liver Oncology Unit, Hospital Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Llarch+N%22">Llarch N</searchLink>; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Liver Oncology Unit, ICMDM, Hospital Clínic, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Iserte+G%22">Iserte G</searchLink>; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Liver Oncology Unit, ICMDM, Hospital Clínic, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Mollà+M%22">Mollà M</searchLink>; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Department of Radiation Oncology, ICAMS, Hospital Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Kelley+RK%22">Kelley RK</searchLink>; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Galle+PR%22">Galle PR</searchLink>; Department of Internal Medicine, Mainz University Medical Center, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Mazzaferro+V%22">Mazzaferro V</searchLink>; Department of Oncology, University of Milan and HPB Surgery and Liver Transplantation, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Salem+R%22">Salem R</searchLink>; Department of Radiology, Section of Interventional Radiology, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Sangro+B%22">Sangro B</searchLink>; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Liver Unit, Clínica Universidad de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Singal+AG%22">Singal AG</searchLink>; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Vogel+A%22">Vogel A</searchLink>; Toronto General Hospital, Princess Margaret Centre, University of Toronto, Toronto, ON, Canada; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Yanagihara+TK%22">Yanagihara TK</searchLink>; University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA; Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ayuso+C%22">Ayuso C</searchLink>; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Radiology Department, Liver Oncology Unit, CDI, Hospital Clínic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Torres+F%22">Torres F</searchLink>; Biostatistics Unit, Medical School, Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bruix+J%22">Bruix J</searchLink>; BCLC Group. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
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