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scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndrome.

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Title: scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndrome.
Authors: Reddy KD; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.; Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany.; Division of Epigenetics of Chronic Lung Diseases, Priority Area Chronic Lung Diseases, Research Center Borstel - Leibniz Lung Center, Borstel, Germany., Maluje Y; Division of Medical Systems Biology, Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany., Ott F; Division of Medical Systems Biology, Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany., Saurabh R; Division of Medical Systems Biology, Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany., Schaaf A; Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany., Bohnhorst A; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.; Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany.; Division of Epigenetics of Chronic Lung Diseases, Priority Area Chronic Lung Diseases, Research Center Borstel - Leibniz Lung Center, Borstel, Germany., Biedermann SB; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.; Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany.; Division of Epigenetics of Chronic Lung Diseases, Priority Area Chronic Lung Diseases, Research Center Borstel - Leibniz Lung Center, Borstel, Germany., Pierstorf J; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.; Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany., Winkelmann S; Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel and UKSH, Campus Kiel, Germany., Voß B; Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel and UKSH, Campus Kiel, Germany., Laudien M; Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel and UKSH, Campus Kiel, Germany., Bahmer T; Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel and UKSH, Campus Kiel, Germany.; Department of Pneumology, Lungen Clinic Grosshansdorf, Grosshansdorf, Germany.; Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany., Heyckendorf J; Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany.; Leibniz Lung Clinic, Department of Internal Medicine I, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany., Brinkmann F; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.; Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany., Schreiber S; Leibniz Lung Clinic, Department of Internal Medicine I, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany., Lieb W; Institute of Epidemiology, Kiel University, Kiel, Germany., Jakwerth CA; Centre of Allergy and Environment (ZAUM), Technische Universität and Helmholtz Centre Munich, Munich, Germany.; Comprehensive Pneumology Centre Munich (CPC-M), Member of The German Centre for Lung Research (DZL), LMU Munich, Germany., Schmidt-Weber CB; Centre of Allergy and Environment (ZAUM), Technische Universität and Helmholtz Centre Munich, Munich, Germany.; Comprehensive Pneumology Centre Munich (CPC-M), Member of The German Centre for Lung Research (DZL), LMU Munich, Germany., Hansen G; Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; Biomedical Research in End stage and Obstructive Lung Disease Hannover (BREATH), Member of the German Centre of Lung Research (DZL), Hannover, Germany.; Cluster of Excellence RESIST (EXC 2155), German Research Foundation (DFG), Hannover Medical School, Hannover, Germany., von Mutius E; Comprehensive Pneumology Centre Munich (CPC-M), Member of The German Centre for Lung Research (DZL), LMU Munich, Germany.; Institute for Asthma and Allergy Prevention, Helmholtz Centre Munich, German Research Centre for Environmental Health, Neuherberg, Germany.; Department of Pulmonary and Allergy, Dr von Hauner University Children's Hospital, Ludwig Maximilian's University, LMU, Munich, Germany., Rabe KF; Department of Pneumology, Lungen Clinic Grosshansdorf, Grosshansdorf, Germany.; Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany., Dittrich AM; Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; Biomedical Research in End stage and Obstructive Lung Disease Hannover (BREATH), Member of the German Centre of Lung Research (DZL), Hannover, Germany.; Cluster of Excellence RESIST (EXC 2155), German Research Foundation (DFG), Hannover Medical School, Hannover, Germany., Maison N; Comprehensive Pneumology Centre Munich (CPC-M), Member of The German Centre for Lung Research (DZL), LMU Munich, Germany.; Institute for Asthma and Allergy Prevention, Helmholtz Centre Munich, German Research Centre for Environmental Health, Neuherberg, Germany.; Department of Pulmonary and Allergy, Dr von Hauner University Children's Hospital, Ludwig Maximilian's University, LMU, Munich, Germany., Schaub B; Comprehensive Pneumology Centre Munich (CPC-M), Member of The German Centre for Lung Research (DZL), LMU Munich, Germany.; Department of Pulmonary and Allergy, Dr von Hauner University Children's Hospital, Ludwig Maximilian's University, LMU, Munich, Germany.; German Center for Child and Adolescent Health (DZKJ), Dr von Hauner Children's Hospital, LMU, Munich, Germany., Kopp MV; Department of Paediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Bern, Switzerland., Busch H; Division of Medical Systems Biology, Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany., Weckmann M; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.; Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany.; Division of Epigenetics of Chronic Lung Diseases, Priority Area Chronic Lung Diseases, Research Center Borstel - Leibniz Lung Center, Borstel, Germany., Fähnrich A; Division of Medical Systems Biology, Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany. anke.faehnrich@uksh.de.; USKH Diagnostics Center, Universtiy Hospital Schleswig-Holstein, Lübeck, Germany. anke.faehnrich@uksh.de.
Corporate Authors: ALLIANCE Study Group as part of the German Centre for Lung Research (DZL)
Source: Nature communications [Nat Commun] 2025 Oct 28; Vol. 16 (1), pp. 9494. Date of Electronic Publication: 2025 Oct 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Reddy+KD%22">Reddy KD</searchLink>; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.; Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany.; Division of Epigenetics of Chronic Lung Diseases, Priority Area Chronic Lung Diseases, Research Center Borstel - Leibniz Lung Center, Borstel, Germany.<br /><searchLink fieldCode="AU" term="%22Maluje+Y%22">Maluje Y</searchLink>; Division of Medical Systems Biology, Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany.<br /><searchLink fieldCode="AU" term="%22Ott+F%22">Ott F</searchLink>; Division of Medical Systems Biology, Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany.<br /><searchLink fieldCode="AU" term="%22Saurabh+R%22">Saurabh R</searchLink>; Division of Medical Systems Biology, Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany.<br /><searchLink fieldCode="AU" term="%22Schaaf+A%22">Schaaf A</searchLink>; Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Bohnhorst+A%22">Bohnhorst A</searchLink>; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.; Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany.; Division of Epigenetics of Chronic Lung Diseases, Priority Area Chronic Lung Diseases, Research Center Borstel - Leibniz Lung Center, Borstel, Germany.<br /><searchLink fieldCode="AU" term="%22Biedermann+SB%22">Biedermann SB</searchLink>; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.; Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany.; Division of Epigenetics of Chronic Lung Diseases, Priority Area Chronic Lung Diseases, Research Center Borstel - Leibniz Lung Center, Borstel, Germany.<br /><searchLink fieldCode="AU" term="%22Pierstorf+J%22">Pierstorf J</searchLink>; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.; Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Winkelmann+S%22">Winkelmann S</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel and UKSH, Campus Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Voß+B%22">Voß B</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel and UKSH, Campus Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Laudien+M%22">Laudien M</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel and UKSH, Campus Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Bahmer+T%22">Bahmer T</searchLink>; Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel and UKSH, Campus Kiel, Germany.; Department of Pneumology, Lungen Clinic Grosshansdorf, Grosshansdorf, Germany.; Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany.<br /><searchLink fieldCode="AU" term="%22Heyckendorf+J%22">Heyckendorf J</searchLink>; Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany.; Leibniz Lung Clinic, Department of Internal Medicine I, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Brinkmann+F%22">Brinkmann F</searchLink>; German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.; Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Schreiber+S%22">Schreiber S</searchLink>; Leibniz Lung Clinic, Department of Internal Medicine I, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Lieb+W%22">Lieb W</searchLink>; 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Cluster of Excellence RESIST (EXC 2155), German Research Foundation (DFG), Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22von+Mutius+E%22">von Mutius E</searchLink>; Comprehensive Pneumology Centre Munich (CPC-M), Member of The German Centre for Lung Research (DZL), LMU Munich, Germany.; Institute for Asthma and Allergy Prevention, Helmholtz Centre Munich, German Research Centre for Environmental Health, Neuherberg, Germany.; Department of Pulmonary and Allergy, Dr von Hauner University Children's Hospital, Ludwig Maximilian's University, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Rabe+KF%22">Rabe KF</searchLink>; Department of Pneumology, Lungen Clinic Grosshansdorf, Grosshansdorf, Germany.; Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany.<br /><searchLink fieldCode="AU" term="%22Dittrich+AM%22">Dittrich AM</searchLink>; Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; 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