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Activation of IRE1 Endonuclease Activity Regulates Zika Virus Replication and Antiviral Response During Infection in Human Microglia.

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Title: Activation of IRE1 Endonuclease Activity Regulates Zika Virus Replication and Antiviral Response During Infection in Human Microglia.
Authors: Hernández-Díaz T; Laboratory of Molecular and Cellular Virology, Núcleo Interdisciplinario de Microbiología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.; Millennium Institute on Immunology and Immunotherapy, Santiago 8331150, Chile.; Center for HIV/AIDS Integral Research, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile., Oyarzún-Arrau A; Laboratory of Molecular and Cellular Virology, Núcleo Interdisciplinario de Microbiología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.; Millennium Institute on Immunology and Immunotherapy, Santiago 8331150, Chile., Gaete-Argel A; Laboratory of Molecular and Cellular Virology, Núcleo Interdisciplinario de Microbiología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.; Millennium Institute on Immunology and Immunotherapy, Santiago 8331150, Chile.; Center for HIV/AIDS Integral Research, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile., López-Palma D; Laboratory of Molecular and Cellular Virology, Núcleo Interdisciplinario de Microbiología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.; Millennium Institute on Immunology and Immunotherapy, Santiago 8331150, Chile.; Center for HIV/AIDS Integral Research, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile., López-Schettini J; Laboratory of Immunology and Cellular Stress, Núcleo Interdisciplinario de Farmacología e Inmunología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile., Fernández D; Laboratory of Immunology and Cellular Stress, Núcleo Interdisciplinario de Farmacología e Inmunología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile., Valiente-Echeverría F; Laboratory of Molecular and Cellular Virology, Núcleo Interdisciplinario de Microbiología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.; Millennium Institute on Immunology and Immunotherapy, Santiago 8331150, Chile.; Center for HIV/AIDS Integral Research, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile., Osorio F; Laboratory of Immunology and Cellular Stress, Núcleo Interdisciplinario de Farmacología e Inmunología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile., Soto-Rifo R; Laboratory of Molecular and Cellular Virology, Núcleo Interdisciplinario de Microbiología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.; Millennium Institute on Immunology and Immunotherapy, Santiago 8331150, Chile.; Center for HIV/AIDS Integral Research, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.
Source: Viruses [Viruses] 2025 Sep 24; Vol. 17 (10). Date of Electronic Publication: 2025 Sep 24.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Activation of IRE1 Endonuclease Activity Regulates Zika Virus Replication and Antiviral Response During Infection in Human Microglia.
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  Data: <searchLink fieldCode="AU" term="%22Hernández-Díaz+T%22">Hernández-Díaz T</searchLink>; Laboratory of Molecular and Cellular Virology, Núcleo Interdisciplinario de Microbiología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.; Millennium Institute on Immunology and Immunotherapy, Santiago 8331150, Chile.; Center for HIV/AIDS Integral Research, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.<br /><searchLink fieldCode="AU" term="%22Oyarzún-Arrau+A%22">Oyarzún-Arrau A</searchLink>; Laboratory of Molecular and Cellular Virology, Núcleo Interdisciplinario de Microbiología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.; Millennium Institute on Immunology and Immunotherapy, Santiago 8331150, Chile.<br /><searchLink fieldCode="AU" term="%22Gaete-Argel+A%22">Gaete-Argel A</searchLink>; Laboratory of Molecular and Cellular Virology, Núcleo Interdisciplinario de Microbiología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.; Millennium Institute on Immunology and Immunotherapy, Santiago 8331150, Chile.; Center for HIV/AIDS Integral Research, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.<br /><searchLink fieldCode="AU" term="%22López-Palma+D%22">López-Palma D</searchLink>; Laboratory of Molecular and Cellular Virology, Núcleo Interdisciplinario de Microbiología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.; Millennium Institute on Immunology and Immunotherapy, Santiago 8331150, Chile.; Center for HIV/AIDS Integral Research, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.<br /><searchLink fieldCode="AU" term="%22López-Schettini+J%22">López-Schettini J</searchLink>; Laboratory of Immunology and Cellular Stress, Núcleo Interdisciplinario de Farmacología e Inmunología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.<br /><searchLink fieldCode="AU" term="%22Fernández+D%22">Fernández D</searchLink>; Laboratory of Immunology and Cellular Stress, Núcleo Interdisciplinario de Farmacología e Inmunología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.<br /><searchLink fieldCode="AU" term="%22Valiente-Echeverría+F%22">Valiente-Echeverría F</searchLink>; Laboratory of Molecular and Cellular Virology, Núcleo Interdisciplinario de Microbiología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.; Millennium Institute on Immunology and Immunotherapy, Santiago 8331150, Chile.; Center for HIV/AIDS Integral Research, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.<br /><searchLink fieldCode="AU" term="%22Osorio+F%22">Osorio F</searchLink>; Laboratory of Immunology and Cellular Stress, Núcleo Interdisciplinario de Farmacología e Inmunología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.<br /><searchLink fieldCode="AU" term="%22Soto-Rifo+R%22">Soto-Rifo R</searchLink>; Laboratory of Molecular and Cellular Virology, Núcleo Interdisciplinario de Microbiología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile.; Millennium Institute on Immunology and Immunotherapy, Santiago 8331150, Chile.; Center for HIV/AIDS Integral Research, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.
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  Data: <searchLink fieldCode="JN" term="%22101509722%22">Viruses</searchLink> [Viruses] 2025 Sep 24; Vol. 17 (10). <i>Date of Electronic Publication: </i>2025 Sep 24.
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