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Lennox-Gastaut syndrome unveiled: Advancing diagnosis, therapies, and advocacy-insights from the Genoa International Workshop.

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Title: Lennox-Gastaut syndrome unveiled: Advancing diagnosis, therapies, and advocacy-insights from the Genoa International Workshop.
Authors: Riva A; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.; IRCCS Istituto 'Giannina Gaslini', Full Member of ERN EpiCARE, Genoa, Italy., D'Onofrio G; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Amadori E; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.; IRCCS Istituto 'Giannina Gaslini', Full Member of ERN EpiCARE, Genoa, Italy., Arzimanoglou A; Epilepsy Unit, Child Neurology Department, Hospital San Juan de Déu, Coordinator of the ERN EpiCARE, Universitat de Barcelona, Barcelona, Spain., Auvin S; INSERM NeuroDiderot, Université Paris Cité, Paris, France.; Pediatric Neurology Department, CRMR Epilepsies Rares, ERN EpiCare, APHP, Robert Debré University Hospital, Paris, France.; Institut Universitaire de France (IUF), Paris, France., Bagnasco I; Division of Child Neuropsychiatry, Martini Hospital, Child Neuropsychiatry ToSud e Asl città di Torino, Turin, Italy., Barabino P; UOC-Unità Operativa Complessa Farmacia, IRCCS Istituto 'Giannina Gaslini', Genoa, Italy., Biagioli V; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Brambilla I; Dravet Italia Onlus, Verona, Italy.; Epag ERN EpiCare, Verona, Italy.; Research Center for Pediatric Epilepsies (CREP), Department of Surgery, Dentistry, Paediatrics and Gynecology, University of Verona, Verona, Italy.; Alleanza Epilessie Rare e Complesse, Italy., Cangemi G; Biochemistry, Pharmacology and Newborn Screening Unit, Central Laboratory of Analysis, IRCCS Istituto Giannina, Gaslini, Genoa, Italy., Coppola A; Epilepsy Center, University Hospital Federico II, Naples, Italy., De Lillo A; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Di Bonaventura C; Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy., Di Gennaro G; IRCCS NEUROMED, Pozzilli, Isernia, Italy., Ferlazzo E; Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy.; Regional Epilepsy Centre, Great Metropolitan 'Bianchi-Melacrino-Morelli Hospital', Reggio Calabria, Italy., Gil-Nagel A; Department of Neurology, Hospital Ruber Internacional, Madrid, Spain.; Fundación Iniciativa Para Las Neurociencias (Fundación INCE), Madrid, Spain., Gobbi G; Associazione Famiglie LGS Italia, Correggio, Italy.; Or.S.A, Treviso, Italy.; Associazione Sclerosi Tuberosa, Rome, Italy., Lattanzi S; Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy., Kluger G; Department of Pediatrics, Institute of Rehabilitation, Transition and Palliation of Neurologically Ill Children, Paracelsus Medical University, Member of the ERN Epicare, Salzburg, Austria.; Center for Pediatric Neurology, Neurorehabilitation and Epileptology, Schoen-Clinic Vogtareuth, Vogtareuth, Germany., Krämer G; Neurocenter Sternen in Zurich, Zurich, Switzerland., Mancardi MM; Child Neuropsychiatry Unit, Full Member of the ERN EpiCARE, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Minetti C; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Nobili L; Child Neuropsychiatry Unit, Full Member of the ERN EpiCARE, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Paravati E; Centro di PsicoMedicina Sistemica, Valeggio Sul Mincio, Verona, Italy., Pringsheim M; Schön Klinik Vogtareuth, Vogtareuth, Germany.; PMU Salzburg, Salzburg, Austria.; TUM Klinikum, German Heart Centre, Munich, Germany., Rebessi E; Pediatric Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland., Romeo A; Associazione Famiglie LGS Italia, Correggio, Italy.; Fatebenefratelli Hospital, ASST Fatebenefratelli Sacco, Milan, Italy., Russo A; U.O.C. Neuropsichiatria Dell'età Pediatrica, Member of the ERN EpiCare, IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Italy., Russo E; Department of Science of Health, Magna Græcia University of Catanzaro, Catanzaro, Italy., Santoro K; Associazione Famiglie LGS Italia, Correggio, Italy., Schubert-Bast S; Center of Neurology and Neurosurgery, Epilepsy Center Frankfurt Rhine-Main, Goethe-University Frankfurt, Frankfurt am Main, Germany.; LOEWE Center for Personalized and Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany.; Department of Pediatric Epileptology, University Children's Hospital, Goethe-University Frankfurt, Frankfurt am Main, Germany., Siri L; Child Neuropsychiatry Unit, Full Member of the ERN EpiCARE, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Sourbron J; Section Pediatric Neurology, Department of Development and Regeneration, University Hospital KU Leuven, Leuven, Belgium.; Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium., Vari MS; Paediatric Neurology and Muscular Disease Unit, IRCCS Istituto 'Giannina Gaslini', Full Member of ERN EpiCARE, Genoa, Italy., Verrotti A; Department of Paediatrics, University of Perugia, Perugia, Italy., Villani F; Clinical Neurophysiology Unit and Epilepsy Center, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Viri M; Department of Child Neurology and Psychiatry, AOU Maggiore Della Carità Novara, Novara, Italy., von Stülpnagel C; Department of Pediatrics, Institute of Rehabilitation, Transition and Palliation of Neurologically Ill Children, Paracelsus Medical University, Member of the ERN Epicare, Salzburg, Austria.; Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Department of Pediatics, Ludwig Maximilians University Munich, Dr von Hauner Children's Hospital, iSPZ Hauner, Munich, Germany., Zamponi N; Child Psychiatry and Neurology Unit, G. Salesi Hospital, Ancona, Italy., Zara F; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.; IRCCS Istituto 'Giannina Gaslini', Full Member of ERN EpiCARE, Genoa, Italy., Striano P; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.; Paediatric Neurology and Muscular Disease Unit, IRCCS Istituto 'Giannina Gaslini', Full Member of ERN EpiCARE, Genoa, Italy.
Source: Epilepsia [Epilepsia] 2026 Feb; Vol. 67 (2), pp. 542-556. Date of Electronic Publication: 2025 Oct 29.
Publication Type: Journal Article; Review
Journal Info: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE
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  Data: Lennox-Gastaut syndrome unveiled: Advancing diagnosis, therapies, and advocacy-insights from the Genoa International Workshop.
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  Data: <searchLink fieldCode="AU" term="%22Riva+A%22">Riva A</searchLink>; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.; IRCCS Istituto 'Giannina Gaslini', Full Member of ERN EpiCARE, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22D'Onofrio+G%22">D'Onofrio G</searchLink>; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Amadori+E%22">Amadori E</searchLink>; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.; IRCCS Istituto 'Giannina Gaslini', Full Member of ERN EpiCARE, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Arzimanoglou+A%22">Arzimanoglou A</searchLink>; Epilepsy Unit, Child Neurology Department, Hospital San Juan de Déu, Coordinator of the ERN EpiCARE, Universitat de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Auvin+S%22">Auvin S</searchLink>; INSERM NeuroDiderot, Université Paris Cité, Paris, France.; Pediatric Neurology Department, CRMR Epilepsies Rares, ERN EpiCare, APHP, Robert Debré University Hospital, Paris, France.; Institut Universitaire de France (IUF), Paris, France.<br /><searchLink fieldCode="AU" term="%22Bagnasco+I%22">Bagnasco I</searchLink>; Division of Child Neuropsychiatry, Martini Hospital, Child Neuropsychiatry ToSud e Asl città di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Barabino+P%22">Barabino P</searchLink>; UOC-Unità Operativa Complessa Farmacia, IRCCS Istituto 'Giannina Gaslini', Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Biagioli+V%22">Biagioli V</searchLink>; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Brambilla+I%22">Brambilla I</searchLink>; Dravet Italia Onlus, Verona, Italy.; Epag ERN EpiCare, Verona, Italy.; Research Center for Pediatric Epilepsies (CREP), Department of Surgery, Dentistry, Paediatrics and Gynecology, University of Verona, Verona, Italy.; Alleanza Epilessie Rare e Complesse, Italy.<br /><searchLink fieldCode="AU" term="%22Cangemi+G%22">Cangemi G</searchLink>; Biochemistry, Pharmacology and Newborn Screening Unit, Central Laboratory of Analysis, IRCCS Istituto Giannina, Gaslini, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Coppola+A%22">Coppola A</searchLink>; Epilepsy Center, University Hospital Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22De+Lillo+A%22">De Lillo A</searchLink>; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Bonaventura+C%22">Di Bonaventura C</searchLink>; Department of Human Neurosciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Gennaro+G%22">Di Gennaro G</searchLink>; IRCCS NEUROMED, Pozzilli, Isernia, Italy.<br /><searchLink fieldCode="AU" term="%22Ferlazzo+E%22">Ferlazzo E</searchLink>; Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy.; Regional Epilepsy Centre, Great Metropolitan 'Bianchi-Melacrino-Morelli Hospital', Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Gil-Nagel+A%22">Gil-Nagel A</searchLink>; Department of Neurology, Hospital Ruber Internacional, Madrid, Spain.; Fundación Iniciativa Para Las Neurociencias (Fundación INCE), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Gobbi+G%22">Gobbi G</searchLink>; Associazione Famiglie LGS Italia, Correggio, Italy.; Or.S.A, Treviso, Italy.; Associazione Sclerosi Tuberosa, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Lattanzi+S%22">Lattanzi S</searchLink>; Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Kluger+G%22">Kluger G</searchLink>; Department of Pediatrics, Institute of Rehabilitation, Transition and Palliation of Neurologically Ill Children, Paracelsus Medical University, Member of the ERN Epicare, Salzburg, Austria.; Center for Pediatric Neurology, Neurorehabilitation and Epileptology, Schoen-Clinic Vogtareuth, Vogtareuth, Germany.<br /><searchLink fieldCode="AU" term="%22Krämer+G%22">Krämer G</searchLink>; Neurocenter Sternen in Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mancardi+MM%22">Mancardi MM</searchLink>; Child Neuropsychiatry Unit, Full Member of the ERN EpiCARE, IRCCS Istituto Giannina Gaslini, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Minetti+C%22">Minetti C</searchLink>; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Nobili+L%22">Nobili L</searchLink>; Child Neuropsychiatry Unit, Full Member of the ERN EpiCARE, IRCCS Istituto Giannina Gaslini, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Paravati+E%22">Paravati E</searchLink>; Centro di PsicoMedicina Sistemica, Valeggio Sul Mincio, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Pringsheim+M%22">Pringsheim M</searchLink>; Schön Klinik Vogtareuth, Vogtareuth, Germany.; PMU Salzburg, Salzburg, Austria.; TUM Klinikum, German Heart Centre, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Rebessi+E%22">Rebessi E</searchLink>; Pediatric Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Romeo+A%22">Romeo A</searchLink>; Associazione Famiglie LGS Italia, Correggio, Italy.; Fatebenefratelli Hospital, ASST Fatebenefratelli Sacco, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+A%22">Russo A</searchLink>; U.O.C. Neuropsichiatria Dell'età Pediatrica, Member of the ERN EpiCare, IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+E%22">Russo E</searchLink>; Department of Science of Health, Magna Græcia University of Catanzaro, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22Santoro+K%22">Santoro K</searchLink>; Associazione Famiglie LGS Italia, Correggio, Italy.<br /><searchLink fieldCode="AU" term="%22Schubert-Bast+S%22">Schubert-Bast S</searchLink>; Center of Neurology and Neurosurgery, Epilepsy Center Frankfurt Rhine-Main, Goethe-University Frankfurt, Frankfurt am Main, Germany.; LOEWE Center for Personalized and Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany.; Department of Pediatric Epileptology, University Children's Hospital, Goethe-University Frankfurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Siri+L%22">Siri L</searchLink>; Child Neuropsychiatry Unit, Full Member of the ERN EpiCARE, IRCCS Istituto Giannina Gaslini, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Sourbron+J%22">Sourbron J</searchLink>; Section Pediatric Neurology, Department of Development and Regeneration, University Hospital KU Leuven, Leuven, Belgium.; Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Vari+MS%22">Vari MS</searchLink>; Paediatric Neurology and Muscular Disease Unit, IRCCS Istituto 'Giannina Gaslini', Full Member of ERN EpiCARE, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Verrotti+A%22">Verrotti A</searchLink>; Department of Paediatrics, University of Perugia, Perugia, Italy.<br /><searchLink fieldCode="AU" term="%22Villani+F%22">Villani F</searchLink>; Clinical Neurophysiology Unit and Epilepsy Center, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Viri+M%22">Viri M</searchLink>; Department of Child Neurology and Psychiatry, AOU Maggiore Della Carità Novara, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22von+Stülpnagel+C%22">von Stülpnagel C</searchLink>; Department of Pediatrics, Institute of Rehabilitation, Transition and Palliation of Neurologically Ill Children, Paracelsus Medical University, Member of the ERN Epicare, Salzburg, Austria.; Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Department of Pediatics, Ludwig Maximilians University Munich, Dr von Hauner Children's Hospital, iSPZ Hauner, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Zamponi+N%22">Zamponi N</searchLink>; Child Psychiatry and Neurology Unit, G. 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