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Genetically heterozygous - transcriptionally homozygous IRF7 deficiency underlies herpesvirus CNS infections in humans.

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Title: Genetically heterozygous - transcriptionally homozygous IRF7 deficiency underlies herpesvirus CNS infections in humans.
Authors: Werner M; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Wolff JH; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark., Taft J; Department of Pediatrics, Center for Genetic Errors of Immunity, Columbia University, New York, NY, USA., Zillinger T; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn , Bonn, Germany., Hinke DM; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Barfod TS; Institute for Clinical Medicine, Copenhagen University , Roskilde, Denmark.; Department of Infectious Diseases, Zealand University Hospital, Roskilde, Denmark., De Keukeleere K; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Winzig F; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Bundgaard B; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark., Narita R; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark., Skov TW; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark., Jensen JA; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Jørgensen SE; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Jørgensen CS; State Serum Institute , Copenhagen, Denmark., Skouboe MK; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark., Lassaunière R; State Serum Institute , Copenhagen, Denmark., de Boer JH; University Medical Center, Utrecht , Utrecht, The Netherlands., Jakobsen MR; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Mikkelsen JG; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark., Bogunovic D; Department of Pediatrics, Center for Genetic Errors of Immunity, Columbia University, New York, NY, USA., Paludan SR; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Sahlgrenska Academy, University of Gothenburg , Gothenburg, Sweden., van der Sluis RM; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark., Mogensen TH; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
Source: The Journal of experimental medicine [J Exp Med] 2026 Jan 05; Vol. 223 (1). Date of Electronic Publication: 2025 Oct 29.
Publication Type: Journal Article
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
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  Data: Genetically heterozygous - transcriptionally homozygous IRF7 deficiency underlies herpesvirus CNS infections in humans.
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  Data: <searchLink fieldCode="AU" term="%22Werner+M%22">Werner M</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Wolff+JH%22">Wolff JH</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Taft+J%22">Taft J</searchLink>; Department of Pediatrics, Center for Genetic Errors of Immunity, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zillinger+T%22">Zillinger T</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn , Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Hinke+DM%22">Hinke DM</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Barfod+TS%22">Barfod TS</searchLink>; Institute for Clinical Medicine, Copenhagen University , Roskilde, Denmark.; Department of Infectious Diseases, Zealand University Hospital, Roskilde, Denmark.<br /><searchLink fieldCode="AU" term="%22De+Keukeleere+K%22">De Keukeleere K</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Winzig+F%22">Winzig F</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Bundgaard+B%22">Bundgaard B</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Narita+R%22">Narita R</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Skov+TW%22">Skov TW</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Jensen+JA%22">Jensen JA</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Jørgensen+SE%22">Jørgensen SE</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Jørgensen+CS%22">Jørgensen CS</searchLink>; State Serum Institute , Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Skouboe+MK%22">Skouboe MK</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Lassaunière+R%22">Lassaunière R</searchLink>; State Serum Institute , Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22de+Boer+JH%22">de Boer JH</searchLink>; University Medical Center, Utrecht , Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Jakobsen+MR%22">Jakobsen MR</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Mikkelsen+JG%22">Mikkelsen JG</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Bogunovic+D%22">Bogunovic D</searchLink>; Department of Pediatrics, Center for Genetic Errors of Immunity, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Paludan+SR%22">Paludan SR</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Sahlgrenska Academy, University of Gothenburg , Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22van+der+Sluis+RM%22">van der Sluis RM</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Mogensen+TH%22">Mogensen TH</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Center for Immunology of Viral Infections, Aarhus University , Aarhus, Denmark.; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
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  Data: <searchLink fieldCode="JN" term="%222985109R%22">The Journal of experimental medicine</searchLink> [J Exp Med] 2026 Jan 05; Vol. 223 (1). <i>Date of Electronic Publication: </i>2025 Oct 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Rockefeller+University+Press%22">Rockefeller University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985109R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1540-9538 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221007%22">00221007 </searchLink><i>NLM ISO Abbreviation: </i>J Exp Med <i>Subsets: </i>MEDLINE
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