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Impact of intraoperatiVe moderAte positive end-expiratory pressure with reCruitment mAnoeuvres versus low positive end-expiRatory pressure on major postoperative pulMonary complications and death after on-pump cardiac surgery in high-risk patients: the VACARM randomised clinical trial-study protocol.

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Title: Impact of intraoperatiVe moderAte positive end-expiratory pressure with reCruitment mAnoeuvres versus low positive end-expiRatory pressure on major postoperative pulMonary complications and death after on-pump cardiac surgery in high-risk patients: the VACARM randomised clinical trial-study protocol.
Authors: Demaure N; Univ Rennes, CHU Rennes, Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), Department of Anesthesia and Critical Care, Pontchaillou, Rennes University Hospital, Rennes, Brittany, France., Le Cunff J; Univ Rennes, CHU Rennes, Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), Department of Anesthesia and Critical Care, Pontchaillou, Rennes University Hospital, Rennes, Brittany, France., Duchêne M; Department of Anesthesia and Critical Care, University Hospital Centre Nantes, Nantes, Pays de la Loire, France., Rozec B; Department of Anesthesia and Critical Care, Laënnec Hospital, University Hospital of Nantes and Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, University Hospital Centre Nantes, Nantes, Pays de la Loire, France., Espitalier F; Department of Anesthesia and Critical Care, Regional University Hospital Centre Tours, Tours, Centre-Val de Loire, France., Cabon JM; Department of Anesthesia and Critical Care, CHU de Brest, Brest, Brittany, France., Oilleau JF; Département d'Anesthésie et Réanimation Chirurgicale, Brest University Hospital Centre, Brest, Brittany, France., Guerci P; Department of Anesthesia and Critical Care, CHU de Nancy, Nancy, Lorraine, France., Labaste F; Department of Anesthesia and Critical Care, University Hospital of Toulouse, Toulouse, France., Abou-Arab O; Department of Anesthesia and Critical Care, Amiens-Picardy University Hospital, Amiens, Hauts-de-France, France., Guinot PG; Burgundy Franche-Comté University, Besancon, France., Duval P; Department of Anesthesia and Critical Care, University Hospital Centre Rouen, Rouen, Normandy, France., Besnier E; Department of Anesthesia and Critical Care, University Hospital Centre Rouen, Rouen, Normandy, France., Flécher E; Cardiothoracic Surgery Unit, Centre Hospitalier Universitaire de Rennes, Rennes, Bretagne, France., Leroyer I; Univ Rennes, CHU de Rennes, Department of Research and Innovation, University Hospital of Rennes, Rennes University Hospital, Rennes, Brittany, France., Morcet J; Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), F-35000 Rennes, Rennes University Hospital, Rennes, Brittany, France., Fougerou-Leurent C; Pharmacology, University Hospital Centre Rennes, Rennes, France.; CIC 1414, INSERM, Rennes, France., Mansour A; Univ Rennes, CHU Rennes, Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), Inra, Inserm, Institut NUMECAN - UMR_A 1341, UMR_S 1241, Department of Anesthesia and Critical Care, Pontchaillou, University Hospital of Rennes, F-35000 Rennes, Rennes University Hospital, Rennes, France., Nesseler N; Univ Rennes, CHU Rennes, Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), Inra, Inserm, Institut NUMECAN - UMR_A 1341, UMR_S 1241, Department of Anesthesia and Critical Care, Pontchaillou, Rennes University Hospital, Rennes, Brittany, France nicolas.nesseler@chu-rennes.fr.
Corporate Authors: VACARM investigators, ATLANREA study group
Source: BMJ open [BMJ Open] 2025 Oct 29; Vol. 15 (10), pp. e104179. Date of Electronic Publication: 2025 Oct 29.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: Impact of intraoperatiVe moderAte positive end-expiratory pressure with reCruitment mAnoeuvres versus low positive end-expiRatory pressure on major postoperative pulMonary complications and death after on-pump cardiac surgery in high-risk patients: the VACARM randomised clinical trial-study protocol.
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  Data: <searchLink fieldCode="AU" term="%22Demaure+N%22">Demaure N</searchLink>; Univ Rennes, CHU Rennes, Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), Department of Anesthesia and Critical Care, Pontchaillou, Rennes University Hospital, Rennes, Brittany, France.<br /><searchLink fieldCode="AU" term="%22Le+Cunff+J%22">Le Cunff J</searchLink>; Univ Rennes, CHU Rennes, Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), Department of Anesthesia and Critical Care, Pontchaillou, Rennes University Hospital, Rennes, Brittany, France.<br /><searchLink fieldCode="AU" term="%22Duchêne+M%22">Duchêne M</searchLink>; Department of Anesthesia and Critical Care, University Hospital Centre Nantes, Nantes, Pays de la Loire, France.<br /><searchLink fieldCode="AU" term="%22Rozec+B%22">Rozec B</searchLink>; Department of Anesthesia and Critical Care, Laënnec Hospital, University Hospital of Nantes and Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, University Hospital Centre Nantes, Nantes, Pays de la Loire, France.<br /><searchLink fieldCode="AU" term="%22Espitalier+F%22">Espitalier F</searchLink>; Department of Anesthesia and Critical Care, Regional University Hospital Centre Tours, Tours, Centre-Val de Loire, France.<br /><searchLink fieldCode="AU" term="%22Cabon+JM%22">Cabon JM</searchLink>; Department of Anesthesia and Critical Care, CHU de Brest, Brest, Brittany, France.<br /><searchLink fieldCode="AU" term="%22Oilleau+JF%22">Oilleau JF</searchLink>; Département d'Anesthésie et Réanimation Chirurgicale, Brest University Hospital Centre, Brest, Brittany, France.<br /><searchLink fieldCode="AU" term="%22Guerci+P%22">Guerci P</searchLink>; Department of Anesthesia and Critical Care, CHU de Nancy, Nancy, Lorraine, France.<br /><searchLink fieldCode="AU" term="%22Labaste+F%22">Labaste F</searchLink>; Department of Anesthesia and Critical Care, University Hospital of Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Abou-Arab+O%22">Abou-Arab O</searchLink>; Department of Anesthesia and Critical Care, Amiens-Picardy University Hospital, Amiens, Hauts-de-France, France.<br /><searchLink fieldCode="AU" term="%22Guinot+PG%22">Guinot PG</searchLink>; Burgundy Franche-Comté University, Besancon, France.<br /><searchLink fieldCode="AU" term="%22Duval+P%22">Duval P</searchLink>; Department of Anesthesia and Critical Care, University Hospital Centre Rouen, Rouen, Normandy, France.<br /><searchLink fieldCode="AU" term="%22Besnier+E%22">Besnier E</searchLink>; Department of Anesthesia and Critical Care, University Hospital Centre Rouen, Rouen, Normandy, France.<br /><searchLink fieldCode="AU" term="%22Flécher+E%22">Flécher E</searchLink>; Cardiothoracic Surgery Unit, Centre Hospitalier Universitaire de Rennes, Rennes, Bretagne, France.<br /><searchLink fieldCode="AU" term="%22Leroyer+I%22">Leroyer I</searchLink>; Univ Rennes, CHU de Rennes, Department of Research and Innovation, University Hospital of Rennes, Rennes University Hospital, Rennes, Brittany, France.<br /><searchLink fieldCode="AU" term="%22Morcet+J%22">Morcet J</searchLink>; Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), F-35000 Rennes, Rennes University Hospital, Rennes, Brittany, France.<br /><searchLink fieldCode="AU" term="%22Fougerou-Leurent+C%22">Fougerou-Leurent C</searchLink>; Pharmacology, University Hospital Centre Rennes, Rennes, France.; CIC 1414, INSERM, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Mansour+A%22">Mansour A</searchLink>; Univ Rennes, CHU Rennes, Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), Inra, Inserm, Institut NUMECAN - UMR_A 1341, UMR_S 1241, Department of Anesthesia and Critical Care, Pontchaillou, University Hospital of Rennes, F-35000 Rennes, Rennes University Hospital, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Nesseler+N%22">Nesseler N</searchLink>; Univ Rennes, CHU Rennes, Inserm, CIC 1414 (Centre d'Investigation Clinique de Rennes), Inra, Inserm, Institut NUMECAN - UMR_A 1341, UMR_S 1241, Department of Anesthesia and Critical Care, Pontchaillou, Rennes University Hospital, Rennes, Brittany, France nicolas.nesseler@chu-rennes.fr.
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  Data: <searchLink fieldCode="CA" term="%22VACARM+investigators%22">VACARM investigators</searchLink><br /><searchLink fieldCode="CA" term="%22ATLANREA+study+group%22">ATLANREA study group</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101552874%22">BMJ open</searchLink> [BMJ Open] 2025 Oct 29; Vol. 15 (10), pp. e104179. <i>Date of Electronic Publication: </i>2025 Oct 29.
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