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Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues.

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Title: Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues.
Authors: Saul D; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. dominik.saul@med.uni-goettingen.de.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. dominik.saul@med.uni-goettingen.de.; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany. dominik.saul@med.uni-goettingen.de.; Eberhard Karls University Tuebingen, Tuebingen, Germany. dominik.saul@med.uni-goettingen.de., Jurk D; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA., Doolittle ML; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA., Kosinsky RL; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Han Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Biochemistry, Konkuk University School of Medicine, Seoul, Republic of Korea., Zhang X; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA., Franco AC; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA., Kim SY; Department of Biochemistry, Konkuk University School of Medicine, Seoul, Republic of Korea.; Research Institute of Medical Science, Konkuk University, Seoul, Republic of Korea., Wyles SP; Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA., Prakash YS; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Anesthesiology, Mayo Clinic, Rochester, MN, 55905, USA., Monroe DG; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA., Ferrucci L; Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA., LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA., Robbins PD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Niedernhofer LJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Khosla S; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. Khosla.Sundeep@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. Khosla.Sundeep@mayo.edu., Passos JF; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. passos.joao@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA. passos.joao@mayo.edu.
Source: The EMBO journal [EMBO J] 2025 Dec; Vol. 44 (23), pp. 7295-7325. Date of Electronic Publication: 2025 Oct 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues.
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  Data: <searchLink fieldCode="AU" term="%22Saul+D%22">Saul D</searchLink>; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. dominik.saul@med.uni-goettingen.de.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. dominik.saul@med.uni-goettingen.de.; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany. dominik.saul@med.uni-goettingen.de.; Eberhard Karls University Tuebingen, Tuebingen, Germany. dominik.saul@med.uni-goettingen.de.<br /><searchLink fieldCode="AU" term="%22Jurk+D%22">Jurk D</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Doolittle+ML%22">Doolittle ML</searchLink>; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Kosinsky+RL%22">Kosinsky RL</searchLink>; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Han+Y%22">Han Y</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Biochemistry, Konkuk University School of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Franco+AC%22">Franco AC</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Kim+SY%22">Kim SY</searchLink>; Department of Biochemistry, Konkuk University School of Medicine, Seoul, Republic of Korea.; Research Institute of Medical Science, Konkuk University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Wyles+SP%22">Wyles SP</searchLink>; Department of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Prakash+YS%22">Prakash YS</searchLink>; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Anesthesiology, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Monroe+DG%22">Monroe DG</searchLink>; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Ferrucci+L%22">Ferrucci L</searchLink>; Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22LeBrasseur+NK%22">LeBrasseur NK</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Robbins+PD%22">Robbins PD</searchLink>; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Niedernhofer+LJ%22">Niedernhofer LJ</searchLink>; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Khosla+S%22">Khosla S</searchLink>; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. Khosla.Sundeep@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. Khosla.Sundeep@mayo.edu.<br /><searchLink fieldCode="AU" term="%22Passos+JF%22">Passos JF</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. passos.joao@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA. passos.joao@mayo.edu.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2025 Dec; Vol. 44 (23), pp. 7295-7325. <i>Date of Electronic Publication: </i>2025 Oct 29.
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