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CpG Methylation-Driven Pleiotropic Spliced Isoforms of PRSS3 Facilitate Gastric Intratumor Heterogeneity and Metastasis.

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Title: CpG Methylation-Driven Pleiotropic Spliced Isoforms of PRSS3 Facilitate Gastric Intratumor Heterogeneity and Metastasis.
Authors: Pang M; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China.; Department of Gastroenterology, Beijing Chest Hospital, Capital Medical University, Beijing, China., Xu H; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China., Li D; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China., Zhang M; Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China., Chen D; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China., Tian R; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China., Gu J; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China., Alimu N; School of Stomatology, Xinjiang Medical University, Urumqi, Xinjiang, China., Wang E; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China., Zhou Z; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China., Li X; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China., Peng Q; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China., He Y; Department of Gastroenterology, Beijing Chest Hospital, Capital Medical University, Beijing, China., Lin S; Department of Gastroenterology, Beijing Chest Hospital, Capital Medical University, Beijing, China., Guo M; Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China., Huang J; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China.
Source: Cancer science [Cancer Sci] 2026 Jan; Vol. 117 (1), pp. 33-49. Date of Electronic Publication: 2025 Oct 29.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7006 (Electronic) Linking ISSN: 13479032 NLM ISO Abbreviation: Cancer Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CpG Methylation-Driven Pleiotropic Spliced Isoforms of PRSS3 Facilitate Gastric Intratumor Heterogeneity and Metastasis.
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  Data: <searchLink fieldCode="AU" term="%22Pang+M%22">Pang M</searchLink>; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China.; Department of Gastroenterology, Beijing Chest Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Tian+R%22">Tian R</searchLink>; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Gu+J%22">Gu J</searchLink>; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Alimu+N%22">Alimu N</searchLink>; School of Stomatology, Xinjiang Medical University, Urumqi, Xinjiang, China.<br /><searchLink fieldCode="AU" term="%22Wang+E%22">Wang E</searchLink>; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Peng+Q%22">Peng Q</searchLink>; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Department of Gastroenterology, Beijing Chest Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lin+S%22">Lin S</searchLink>; Department of Gastroenterology, Beijing Chest Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Guo+M%22">Guo M</searchLink>; Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; College of Life Sciences & Bioengineering, Beijing Jiaotong University, Beijing, China.
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  Data: <searchLink fieldCode="JN" term="%22101168776%22">Cancer science</searchLink> [Cancer Sci] 2026 Jan; Vol. 117 (1), pp. 33-49. <i>Date of Electronic Publication: </i>2025 Oct 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley+Publishing+on+behalf+of+the+Japanese+Cancer+Association%22">Wiley Publishing on behalf of the Japanese Cancer Association </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101168776 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1349-7006 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213479032%22">13479032 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Sci <i>Subsets: </i>MEDLINE
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              Text: 2026 Jan
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