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Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia.

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Title: Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia.
Authors: Prakash TP; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States., Mullick AE; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States., Riney S; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States., Yu J; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States., Nikan M; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States., Quirk C; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States., Crutchfield A; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States., Damle SS; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States., Klein S; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States., Swayze EE; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States.
Source: Nucleic acids research [Nucleic Acids Res] 2025 Oct 28; Vol. 53 (20).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia.
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  Data: <searchLink fieldCode="AU" term="%22Prakash+TP%22">Prakash TP</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Mullick+AE%22">Mullick AE</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Riney+S%22">Riney S</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Nikan+M%22">Nikan M</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Quirk+C%22">Quirk C</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Crutchfield+A%22">Crutchfield A</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Damle+SS%22">Damle SS</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Klein+S%22">Klein S</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States.<br /><searchLink fieldCode="AU" term="%22Swayze+EE%22">Swayze EE</searchLink>; Ionis Pharmaceuticals Inc., 2855 Gazelle Ct., Carlsbad CA 92010, United States.
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        Value: 10.1093/nar/gkaf1063
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            – D: 28
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              Text: 2025 Oct 28
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