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Phase I/II Study of AXL-Specific Antibody-Drug Conjugate Enapotamab Vedotin in Patients with Advanced Solid Tumors.

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Title: Phase I/II Study of AXL-Specific Antibody-Drug Conjugate Enapotamab Vedotin in Patients with Advanced Solid Tumors.
Authors: Rohrberg KS; Department of Oncology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Lopez JS; Drug Development Unit, Royal Marsden Hospital/Institute of Cancer Research, Sutton, United Kingdom., Milhem MM; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa., Blank CU; Division of Molecular Oncology and Immunology, Department of Medical Oncology, Netherlands Cancer Institute (NKI), Amsterdam, the Netherlands.; Department of Medical Oncology, Leiden University Medical Center (LUMC), Leiden, the Netherlands.; Department of Hematology and Oncology, University Clinic Regensburg (UKR), Regensburg, Germany., Reijers I; Division of Molecular Oncology and Immunology, Department of Medical Oncology, Netherlands Cancer Institute (NKI), Amsterdam, the Netherlands., Thistlethwaite F; The Christie NHS Foundation Trust and Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom., Plummer R; Newcastle University, Newcastle upon Tyne, United Kingdom., Piha-Paul SA; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas., Jänne PA; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Shum E; Medical Oncology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, New York., Shaw HM; National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Clinical Research Facility, National Health Service (NHS) Foundation Trust, London, United Kingdom.; Department of Medical Oncology, Mount Vernon Cancer Centre, Northwood, United Kingdom., Debruyne PR; Department of Medical Oncology, Kortrijk Cancer Centre, AZ Groeninge, Kortrijk, Belgium.; Medical Technology Research Centre (MTRC), School of Allied Health and Social Care, Faculty of Health, Medicine and Social Care, Anglia Ruskin University, Chelmsford, United Kingdom.; School of Nursing and Midwifery, Faculty of Health, University of Plymouth, Plymouth, United Kingdom., Lao C; Division of Hematology Oncology, Department of Internal Medicine, Rogel Cancer Center, Ann Arbor, Michigan., Baurain JF; Department of Medical Oncology, Institut Roi Albert II, Cliniques Universitaires Saint-Luc, UC Louvain and Institute for Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium., Choe JH; Division of Hematology and Oncology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee., Gort E; Department of Medical Oncology, UMC Utrecht Cancer Center, Utrecht, the Netherlands., Zhao Y; Department of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida., Jerusalem G; Medical Oncology Department, CHU Liège and Liège University, Liege, Belgium., Schöffski P; General Medical Oncology, University Hospitals Leuven, Leuven, Belgium., Chen AW; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Radiology, Columbia University, New York, New York., Cohen EA; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Radiology, Columbia University, New York, New York., Mankowski WC; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Radiology, Columbia University, New York, New York., Roshkovan L; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Katz SI; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Kontos D; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Radiology, Columbia University, New York, New York., Brady LK; Genmab US., Plainsboro, New Jersey., Qutaish M; Genmab US., Plainsboro, New Jersey., Castro PG; Genmab B.V., Utrecht, the Netherlands., Pencheva N; Genmab B.V., Utrecht, the Netherlands., Bajaj G; Genmab US., Plainsboro, New Jersey., Fu Y; Genmab US., Plainsboro, New Jersey., Windfeld K; Genmab A/S, Copenhagen, Denmark., Reiter P; Genmab A/S, Copenhagen, Denmark., Jure-Kunkel M; Genmab US., Plainsboro, New Jersey., Higgs BW; Genmab US., Plainsboro, New Jersey., Amiri KI; Genmab US., Plainsboro, New Jersey., Ahmadi T; Genmab US., Plainsboro, New Jersey., Forssmann U; Genmab A/S, Copenhagen, Denmark., Ramalingam SS; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia., Vergote I; Department of Gynecology and Obstetrics, Gynecologic Oncology, Leuven Cancer Institute, Catholic University Leuven, Leuven, Belgium.
Source: Cancer research communications [Cancer Res Commun] 2025 Nov 01; Vol. 5 (11), pp. 2066-2078.
Publication Type: Journal Article; Clinical Trial, Phase I; Clinical Trial, Phase II; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase I/II Study of AXL-Specific Antibody-Drug Conjugate Enapotamab Vedotin in Patients with Advanced Solid Tumors.
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Division of Molecular Oncology and Immunology, Department of Medical Oncology, Netherlands Cancer Institute (NKI), Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Thistlethwaite+F%22">Thistlethwaite F</searchLink>; The Christie NHS Foundation Trust and Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Plummer+R%22">Plummer R</searchLink>; Newcastle University, Newcastle upon Tyne, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Piha-Paul+SA%22">Piha-Paul SA</searchLink>; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Jänne+PA%22">Jänne PA</searchLink>; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Shum+E%22">Shum E</searchLink>; Medical Oncology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Shaw+HM%22">Shaw HM</searchLink>; National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Clinical Research Facility, National Health Service (NHS) Foundation Trust, London, United Kingdom.; Department of Medical Oncology, Mount Vernon Cancer Centre, Northwood, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Debruyne+PR%22">Debruyne PR</searchLink>; Department of Medical Oncology, Kortrijk Cancer Centre, AZ Groeninge, Kortrijk, Belgium.; Medical Technology Research Centre (MTRC), School of Allied Health and Social Care, Faculty of Health, Medicine and Social Care, Anglia Ruskin University, Chelmsford, United Kingdom.; School of Nursing and Midwifery, Faculty of Health, University of Plymouth, Plymouth, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lao+C%22">Lao C</searchLink>; Division of Hematology Oncology, Department of Internal Medicine, Rogel Cancer Center, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Baurain+JF%22">Baurain JF</searchLink>; Department of Medical Oncology, Institut Roi Albert II, Cliniques Universitaires Saint-Luc, UC Louvain and Institute for Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Choe+JH%22">Choe JH</searchLink>; Division of Hematology and Oncology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.<br /><searchLink fieldCode="AU" term="%22Gort+E%22">Gort E</searchLink>; Department of Medical Oncology, UMC Utrecht Cancer Center, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of Hematology and Oncology, Mayo Clinic, Jacksonville, Florida.<br /><searchLink fieldCode="AU" term="%22Jerusalem+G%22">Jerusalem G</searchLink>; Medical Oncology Department, CHU Liège and Liège University, Liege, Belgium.<br /><searchLink fieldCode="AU" term="%22Schöffski+P%22">Schöffski P</searchLink>; General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Chen+AW%22">Chen AW</searchLink>; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Radiology, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Cohen+EA%22">Cohen EA</searchLink>; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Radiology, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Mankowski+WC%22">Mankowski WC</searchLink>; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Radiology, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Roshkovan+L%22">Roshkovan L</searchLink>; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Katz+SI%22">Katz SI</searchLink>; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Kontos+D%22">Kontos D</searchLink>; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Radiology, Columbia University, New York, New York.<br /><searchLink fieldCode="AU" term="%22Brady+LK%22">Brady LK</searchLink>; Genmab US., Plainsboro, New Jersey.<br /><searchLink fieldCode="AU" term="%22Qutaish+M%22">Qutaish M</searchLink>; Genmab US., Plainsboro, New Jersey.<br /><searchLink fieldCode="AU" term="%22Castro+PG%22">Castro PG</searchLink>; Genmab B.V., Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Pencheva+N%22">Pencheva N</searchLink>; Genmab B.V., Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bajaj+G%22">Bajaj G</searchLink>; Genmab US., Plainsboro, New Jersey.<br /><searchLink fieldCode="AU" term="%22Fu+Y%22">Fu Y</searchLink>; Genmab US., Plainsboro, New Jersey.<br /><searchLink fieldCode="AU" term="%22Windfeld+K%22">Windfeld K</searchLink>; Genmab A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Reiter+P%22">Reiter P</searchLink>; Genmab A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jure-Kunkel+M%22">Jure-Kunkel M</searchLink>; Genmab US., Plainsboro, New Jersey.<br /><searchLink fieldCode="AU" term="%22Higgs+BW%22">Higgs BW</searchLink>; Genmab US., Plainsboro, New Jersey.<br /><searchLink fieldCode="AU" term="%22Amiri+KI%22">Amiri KI</searchLink>; Genmab US., Plainsboro, New Jersey.<br /><searchLink fieldCode="AU" term="%22Ahmadi+T%22">Ahmadi T</searchLink>; Genmab US., Plainsboro, New Jersey.<br /><searchLink fieldCode="AU" term="%22Forssmann+U%22">Forssmann U</searchLink>; Genmab A/S, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ramalingam+SS%22">Ramalingam SS</searchLink>; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Vergote+I%22">Vergote I</searchLink>; Department of Gynecology and Obstetrics, Gynecologic Oncology, Leuven Cancer Institute, Catholic University Leuven, Leuven, Belgium.
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