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Vinculin mediates a dynamic signal flow underlying cardiac outflow tract development as revealed by single-cell and spatial transcriptomic analysis.

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Title: Vinculin mediates a dynamic signal flow underlying cardiac outflow tract development as revealed by single-cell and spatial transcriptomic analysis.
Authors: Wang RX; Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong., Liang M; School of Biomedical Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong., Wang X; Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong., Pan Y; School of Biomedical Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong., Li Z; Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong., Hui CC; Program in Developmental & Stem Cell Biology, The Hospital for Sick Children and Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 0A4, Canada., Kim KH; University of Ottawa Heart Institute and Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1Y 4W7, Canada., Javed A; School of Biomedical Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong. Electronic address: javed@hku.hk., Ngan ES; Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong. Electronic address: engan@hku.hk.
Source: Journal of advanced research [J Adv Res] 2026 Jul; Vol. 85, pp. 441-454. Date of Electronic Publication: 2025 Oct 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Vinculin mediates a dynamic signal flow underlying cardiac outflow tract development as revealed by single-cell and spatial transcriptomic analysis.
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  Data: <searchLink fieldCode="AU" term="%22Wang+RX%22">Wang RX</searchLink>; Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Liang+M%22">Liang M</searchLink>; School of Biomedical Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Pan+Y%22">Pan Y</searchLink>; School of Biomedical Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Hui+CC%22">Hui CC</searchLink>; Program in Developmental & Stem Cell Biology, The Hospital for Sick Children and Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Kim+KH%22">Kim KH</searchLink>; University of Ottawa Heart Institute and Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1Y 4W7, Canada.<br /><searchLink fieldCode="AU" term="%22Javed+A%22">Javed A</searchLink>; School of Biomedical Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong. Electronic address: javed@hku.hk.<br /><searchLink fieldCode="AU" term="%22Ngan+ES%22">Ngan ES</searchLink>; Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong. Electronic address: engan@hku.hk.
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  Data: <searchLink fieldCode="JN" term="%22101546952%22">Journal of advanced research</searchLink> [J Adv Res] 2026 Jul; Vol. 85, pp. 441-454. <i>Date of Electronic Publication: </i>2025 Oct 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cairo+University%2C+production+and+hosting+by+Elsevier+B%2E+V%22">Cairo University, production and hosting by Elsevier B. V </searchLink><i>Country of Publication: </i>Egypt <i>NLM ID: </i>101546952 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2090-1224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220901224%22">20901224 </searchLink><i>NLM ISO Abbreviation: </i>J Adv Res <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.jare.2025.10.062
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      – Code: eng
        Text: English
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        StartPage: 441
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      – TitleFull: Vinculin mediates a dynamic signal flow underlying cardiac outflow tract development as revealed by single-cell and spatial transcriptomic analysis.
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            – D: 01
              M: 07
              Text: 2026 Jul
              Type: published
              Y: 2026
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