Scaffold optimization of indeno[2,1-g]pteridine sulfonates for enhanced DNA interactions, ROS generation, and Topo II inhibition.
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| Title: | Scaffold optimization of indeno[2,1-g]pteridine sulfonates for enhanced DNA interactions, ROS generation, and Topo II inhibition. |
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| Authors: | Cao MN; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, People's Republic of China., Wang JG; Zhuohang New Material Co., Ltd., Heze, 274900, People's Republic of China., Ju K; Zhuohang New Material Co., Ltd., Heze, 274900, People's Republic of China., Liu YH; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, People's Republic of China., Yu RL; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China., Xia YM; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, People's Republic of China. Electronic address: xiayamu@126.com., Gao WW; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, People's Republic of China. Electronic address: gww501@qust.edu.cn. |
| Source: | European journal of medicinal chemistry [Eur J Med Chem] 2026 Jan 15; Vol. 302 (Pt 1), pp. 118313. Date of Electronic Publication: 2025 Oct 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41172650 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Scaffold optimization of indeno[2,1-g]pteridine sulfonates for enhanced DNA interactions, ROS generation, and Topo II inhibition. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Cao+MN%22">Cao MN</searchLink>; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wang+JG%22">Wang JG</searchLink>; Zhuohang New Material Co., Ltd., Heze, 274900, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Ju+K%22">Ju K</searchLink>; Zhuohang New Material Co., Ltd., Heze, 274900, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+YH%22">Liu YH</searchLink>; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Yu+RL%22">Yu RL</searchLink>; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Xia+YM%22">Xia YM</searchLink>; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, People's Republic of China. Electronic address: xiayamu@126.com.<br /><searchLink fieldCode="AU" term="%22Gao+WW%22">Gao WW</searchLink>; Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, People's Republic of China. Electronic address: gww501@qust.edu.cn. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2026 Jan 15; Vol. 302 (Pt 1), pp. 118313. <i>Date of Electronic Publication: </i>2025 Oct 28. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41172650 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ejmech.2025.118313 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 118313 Titles: – TitleFull: Scaffold optimization of indeno[2,1-g]pteridine sulfonates for enhanced DNA interactions, ROS generation, and Topo II inhibition. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Cao MN – PersonEntity: Name: NameFull: Wang JG – PersonEntity: Name: NameFull: Ju K – PersonEntity: Name: NameFull: Liu YH – PersonEntity: Name: NameFull: Yu RL – PersonEntity: Name: NameFull: Xia YM – PersonEntity: Name: NameFull: Gao WW IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 01 Text: 2026 Jan 15 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1768-3254 Numbering: – Type: volume Value: 302 – Type: issue Value: Pt 1 Titles: – TitleFull: European journal of medicinal chemistry Type: main |
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