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Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT10/mTOR signaling axis.

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Title: Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT10/mTOR signaling axis.
Authors: Sun H; Department of Spine Surgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan West Road, Wuhu, Anhui 241001, China. Electronic address: 976957465@qq.com., Wu Z; Department of Spine Surgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan West Road, Wuhu, Anhui 241001, China. Electronic address: 2316674820@qq.com., Zhang Y; Spine Research Center of Wannan Medical College, No.22 Wenchang West Road, Wuhu, Anhui 241001, China. Electronic address: lakerszy@126.com., Liu C; Spine Research Center of Wannan Medical College, No.22 Wenchang West Road, Wuhu, Anhui 241001, China. Electronic address: 18715536572@163.com., Gao D; Department of Spine Surgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan West Road, Wuhu, Anhui 241001, China. Electronic address: 895164183@qq.com., Zhao Q; Department of Spine Surgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan West Road, Wuhu, Anhui 241001, China. Electronic address: quanlai1986@126.com., Xiao L; Department of Spine Surgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan West Road, Wuhu, Anhui 241001, China; Key Laboratory of Non-Coding RNA Transformation Research of Anhui Higher Education Institution, No. 2 Zheshan West Road, Wuhu, Anhui 241001, China. Electronic address: xlllan2012@126.com.
Source: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2026 Apr; Vol. 34 (4), pp. 550-562. Date of Electronic Publication: 2025 Oct 30.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: W.B. Saunders For The Osteoarthritis Research Society Country of Publication: England NLM ID: 9305697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-9653 (Electronic) Linking ISSN: 10634584 NLM ISO Abbreviation: Osteoarthritis Cartilage Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT10/mTOR signaling axis.
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  Data: <searchLink fieldCode="AU" term="%22Sun+H%22">Sun H</searchLink>; Department of Spine Surgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan West Road, Wuhu, Anhui 241001, China. Electronic address: 976957465@qq.com.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Department of Spine Surgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan West Road, Wuhu, Anhui 241001, China. Electronic address: 2316674820@qq.com.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Spine Research Center of Wannan Medical College, No.22 Wenchang West Road, Wuhu, Anhui 241001, China. Electronic address: lakerszy@126.com.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Spine Research Center of Wannan Medical College, No.22 Wenchang West Road, Wuhu, Anhui 241001, China. Electronic address: 18715536572@163.com.<br /><searchLink fieldCode="AU" term="%22Gao+D%22">Gao D</searchLink>; Department of Spine Surgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan West Road, Wuhu, Anhui 241001, China. Electronic address: 895164183@qq.com.<br /><searchLink fieldCode="AU" term="%22Zhao+Q%22">Zhao Q</searchLink>; Department of Spine Surgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan West Road, Wuhu, Anhui 241001, China. Electronic address: quanlai1986@126.com.<br /><searchLink fieldCode="AU" term="%22Xiao+L%22">Xiao L</searchLink>; Department of Spine Surgery, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan West Road, Wuhu, Anhui 241001, China; Key Laboratory of Non-Coding RNA Transformation Research of Anhui Higher Education Institution, No. 2 Zheshan West Road, Wuhu, Anhui 241001, China. Electronic address: xlllan2012@126.com.
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  Data: <searchLink fieldCode="JN" term="%229305697%22">Osteoarthritis and cartilage</searchLink> [Osteoarthritis Cartilage] 2026 Apr; Vol. 34 (4), pp. 550-562. <i>Date of Electronic Publication: </i>2025 Oct 30.
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  Data: Journal Article; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22W%2EB%2E+Saunders+For+The+Osteoarthritis+Research+Society%22">W.B. Saunders For The Osteoarthritis Research Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9305697 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-9653 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210634584%22">10634584 </searchLink><i>NLM ISO Abbreviation: </i>Osteoarthritis Cartilage <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.joca.2025.10.014
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      – Code: eng
        Text: English
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        StartPage: 550
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      – TitleFull: Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT10/mTOR signaling axis.
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            NameFull: Sun H
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            NameFull: Zhao Q
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            – D: 01
              M: 04
              Text: 2026 Apr
              Type: published
              Y: 2026
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              Value: 1522-9653
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              Value: 34
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              Value: 4
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