Microfracture with or without collagen scaffold insertion for adults with chondral or osteochondral defects of the knee: the SISMIC RCT and its challenges during and after the COVID-19 pandemic.

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Title: Microfracture with or without collagen scaffold insertion for adults with chondral or osteochondral defects of the knee: the SISMIC RCT and its challenges during and after the COVID-19 pandemic.
Authors: Whitehouse MR; Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK.; The NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, UK.; Avon Orthopaedic Centre, Neuroscience and Musculoskeletal Division, North Bristol NHS Trust, Southmead Hospital, Bristol, UK., Howells N; Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK.; Avon Orthopaedic Centre, Neuroscience and Musculoskeletal Division, North Bristol NHS Trust, Southmead Hospital, Bristol, UK., Dabner L; Bristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, UK., Thirard R; Bristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, UK., Culliford L; Bristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, UK., Marques E; Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK., Baji P; Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK., Judge A; Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK.; The NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, UK., Blom AW; The NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, UK.; Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK., Burston A; Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK., Jameson C; Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK., Rogers CA; Bristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, UK.
Source: Health technology assessment (Winchester, England) [Health Technol Assess] 2025 Oct 29, pp. 1-25. Date of Electronic Publication: 2025 Oct 29.
Publication Type: Journal Article
Journal Info: Publisher: NIHR Journals Library Country of Publication: England NLM ID: 9706284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2046-4924 (Electronic) Linking ISSN: 13665278 NLM ISO Abbreviation: Health Technol Assess Subsets: MEDLINE
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  Data: Microfracture with or without collagen scaffold insertion for adults with chondral or osteochondral defects of the knee: the SISMIC RCT and its challenges during and after the COVID-19 pandemic.
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  Data: <searchLink fieldCode="AU" term="%22Whitehouse+MR%22">Whitehouse MR</searchLink>; Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK.; The NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, UK.; Avon Orthopaedic Centre, Neuroscience and Musculoskeletal Division, North Bristol NHS Trust, Southmead Hospital, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Howells+N%22">Howells N</searchLink>; Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK.; Avon Orthopaedic Centre, Neuroscience and Musculoskeletal Division, North Bristol NHS Trust, Southmead Hospital, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Dabner+L%22">Dabner L</searchLink>; Bristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Thirard+R%22">Thirard R</searchLink>; Bristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Culliford+L%22">Culliford L</searchLink>; Bristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Marques+E%22">Marques E</searchLink>; Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Baji+P%22">Baji P</searchLink>; Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Judge+A%22">Judge A</searchLink>; Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK.; The NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Blom+AW%22">Blom AW</searchLink>; The NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, UK.; Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Burston+A%22">Burston A</searchLink>; Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Jameson+C%22">Jameson C</searchLink>; Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Rogers+CA%22">Rogers CA</searchLink>; Bristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, UK.
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  Data: <searchLink fieldCode="JN" term="%229706284%22">Health technology assessment (Winchester, England)</searchLink> [Health Technol Assess] 2025 Oct 29, pp. 1-25. <i>Date of Electronic Publication: </i>2025 Oct 29.
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