A biomimetic model composed of injectable 3D muscle-like tissue, stromal and immune cells for recapitulating the rapid immune signature predictive of mRNA vaccine immunogenicity.

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Title: A biomimetic model composed of injectable 3D muscle-like tissue, stromal and immune cells for recapitulating the rapid immune signature predictive of mRNA vaccine immunogenicity.
Authors: Etna MP; Istituto Superiore di Sanità, Department of Infectious Diseases, Rome, Italy., Fuoco C; Department of Biology, University of Rome Tor Vergata, Rome, Italy., Severa M; Istituto Superiore di Sanità, Department of Infectious Diseases, Rome, Italy., Ricci D; Istituto Superiore di Sanità, Department of Infectious Diseases, Rome, Italy., Sinigaglia A; Department of Molecular Medicine, University of Padova, Padua, Italy., Lucca C; Department of Molecular Medicine, University of Padova, Padua, Italy., Cairo G; Istituto Superiore di Sanità, Department of Infectious Diseases, Rome, Italy., Bottazzi B; Department of Inflammation and Immunology, Humanitas Clinical and Research Centre - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy., Garlanda C; Department of Inflammation and Immunology, Humanitas Clinical and Research Centre - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Palamara AT; Istituto Superiore di Sanità, Department of Infectious Diseases, Rome, Italy., Barzon L; Department of Molecular Medicine, University of Padova, Padua, Italy., Gargioli C; Department of Biology, University of Rome Tor Vergata, Rome, Italy., Coccia EM; Istituto Superiore di Sanità, Department of Infectious Diseases, Rome, Italy.
Source: Frontiers in immunology [Front Immunol] 2025 Oct 10; Vol. 16, pp. 1651095. Date of Electronic Publication: 2025 Oct 10 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-3224
DOI:10.3389/fimmu.2025.1651095